ES2137665T3 - Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos. - Google Patents

Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos.

Info

Publication number
ES2137665T3
ES2137665T3 ES96904021T ES96904021T ES2137665T3 ES 2137665 T3 ES2137665 T3 ES 2137665T3 ES 96904021 T ES96904021 T ES 96904021T ES 96904021 T ES96904021 T ES 96904021T ES 2137665 T3 ES2137665 T3 ES 2137665T3
Authority
ES
Spain
Prior art keywords
compounds
piridazine
piridine
procedures
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96904021T
Other languages
English (en)
Inventor
Christos Tsaklakidis
Alfred Mertens
Gerd Zimmermann
Wolfgang Schafer
Liesel Dorge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Application granted granted Critical
Publication of ES2137665T3 publication Critical patent/ES2137665T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE PROPONEN UNOS COMPUESTOS DE FORMULA (I), EN DONDE R{SUP,1} ES HIDROGENO, ALQUILO BAJO, ALQUENILO BAJO, CICLOALQUILO, CICLOALQUENILO, UN ARILO MONOCICLICO O BICICLICO OPCIONALMENTE SUSTITUTIDO, UN HETARIL OPCIONALMENTE SUSTITUIDO, UN ARILALQUILO OPCIONALMENTE SUSTITUIDO O UNO DE LOS GRUPOS -OR{SUP,2}, NR{SUP,3}R{SUP,4}, W ES NITROGENO O =CR{SUP,5}, X, Y, Z SON, INDEPENDIENTEMENTE UNO DEL OTRO, NITROGENO O EL GRUPO =CH, Y PARA EN EL CASO DE QUE W CORRESPONDA AL GRUPO =CR{SUP,5} Y X SEA EL GRUPO =CH, Y NO PODRA SER EL GRUPO =CH; A ES OXIGENO, =NR{SUP,2} O =N-P, N ES 0 HASTA 5, P CORRESPONDE A UN GRUPO PROTECTOR PARA AMINAS COMO EL ACETILO, TERT.-BUTILOXICARBONILO O BENCILOXICARBONILO, R{SUP,2} ES HIDROGENO, ALQUILO BAJO O ARILOALQUILO BAJO, R{SUP,3} Y R{SUP,4} SIGNIFICAN, INDEPENDIENTEMENTE UNO DEL OTRO, HIDROGENO O ALQUILO BAJO O FORMAN, JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN LIGADOS, UN ANILLO HETEROCICLICO DE CINCO HASTA SEIS MIEMBROS, R{SUP,5} ES HIDROGENO O UN GRUPO OR{SUP,2}. LAINVENCION TRATA TAMBIEN DEL PROCEDIMIENTO PARA SU PRODUCCION, ASI COMO LOS MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS PARA EL TRATAMIENTO DE ENFERMEDADES ATRIBUIBLES A ACCIDENTES TROMBOEMBOLICOS.
ES96904021T 1995-02-10 1996-02-08 Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos. Expired - Lifetime ES2137665T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19504367A DE19504367A1 (de) 1995-02-10 1995-02-10 Neue Pyridin- bzw. Pyridazinderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2137665T3 true ES2137665T3 (es) 1999-12-16

Family

ID=7753600

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96904021T Expired - Lifetime ES2137665T3 (es) 1995-02-10 1996-02-08 Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos.

Country Status (13)

Country Link
US (1) US5786371A (es)
EP (1) EP0808306B1 (es)
JP (1) JPH11504618A (es)
AT (1) ATE182886T1 (es)
AU (1) AU4788696A (es)
CA (1) CA2212336A1 (es)
DE (2) DE19504367A1 (es)
DK (1) DK0808306T3 (es)
ES (1) ES2137665T3 (es)
GR (1) GR3031544T3 (es)
IL (1) IL117083A (es)
WO (1) WO1996024586A1 (es)
ZA (1) ZA961044B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069143A (en) * 1994-12-20 2000-05-30 Smithkline Beecham Corporation Fibrinogen receptor antagonists
UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US5876687A (en) * 1997-04-04 1999-03-02 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Elemental metals or oxides distributed on a carbon substrate or self-supported and the manufacturing process using graphite oxide as template
DE19815026A1 (de) 1998-04-03 1999-10-07 Hoechst Schering Agrevo Gmbh Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2155307A1 (en) * 1993-03-29 1994-10-13 Michael Garth Wayne Heterocyclic compounds as platelet aggregation inhibitors

Also Published As

Publication number Publication date
JPH11504618A (ja) 1999-04-27
DK0808306T3 (da) 2000-03-06
AU4788696A (en) 1996-08-27
IL117083A0 (en) 1996-06-18
ATE182886T1 (de) 1999-08-15
EP0808306A1 (de) 1997-11-26
DE19504367A1 (de) 1996-08-14
EP0808306B1 (de) 1999-08-04
CA2212336A1 (en) 1996-08-15
GR3031544T3 (en) 2000-01-31
IL117083A (en) 2000-12-06
US5786371A (en) 1998-07-28
DE59602622D1 (de) 1999-09-09
WO1996024586A1 (de) 1996-08-15
ZA961044B (en) 1997-08-11

Similar Documents

Publication Publication Date Title
DZ1794A1 (fr) Nouvelle formule pharmaceutique.
DE59409312D1 (de) Imidazopyridine und ihre anwendung zur behandlung von magen-darm krankheiten
NO995006D0 (no) Nye forbindelser
UA44254C2 (uk) Похідні 4-(заміщеного феніламіно)хіназоліну, спосіб їх одержання, спосіб лікування і фармацевтична композиція
HUT77925A (hu) Dihidrobenzofuránok, azokat tartalmazó gyógyászati készítmények és eljárás előállításukra
DE69736441D1 (de) Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
NO945034L (no) Derivater i vitamin D-serien modifisert ved 20-stilling, en fremg. for frems. av slike derivater, mellomprodukter anvendt ved fremg., farmasöytiske preparater inneholdende derivatene og deres anvendelse ved frems. av legemidler
MX9704037A (es) 1,1-dioxidos de 1,2,5-tiadiazolidin-3-ona 2-substituida y composiciones y metodo de uso de los mismos.
ES2122637T3 (es) Derivados de tiazolidina, su preparacion y los medicamentos que les contienen.
BR9609847A (pt) Derivados de N-(4-Benzila-substituída)-2-aminolactam
ATE85334T1 (de) Bisphenylalkylpiperazin-derivate, verfahren zur herstellung und arzneimittelzubereitung.
DE69805305D1 (de) Verwendung von phanquinon zur behandlung von alzheimer's krankheit
ES2137665T3 (es) Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos.
DK0866711T3 (da) Anvendelse af 6-methyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamid til fremstilling af et farmaceutisk præparat til modvirkning af sövnapnö
BR9610175A (pt) Composto processo de preparação do composto composição farmacêutica e utilização do composto
NZ320522A (en) Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the compounds
ES2123796T3 (es) Derivados de acidos fosfono-succinicos y su utilizacion como medicamentos.
ES2140544T3 (es) Utilizacion de efaroxan y de sus derivados para la fabricacion de medicamentos destinados al tratamiento de las enfermedades neurodegenerativas.
DK0825859T3 (da) Anvendelse af forskolin eller ekstrakter indeholdende dette til fremstilling af et lægemiddel til behandling af alkoholafhængighed
ATE168697T1 (de) Pyrrolidinderivate zur behandlung von cck und gastrin-abhängigen erkrankungen
EE9700327A (et) Meetod anhüdroekgoniini estrite valmistamiseks
NO974687D0 (no) Kondenserte <beta>-carboliner

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 808306

Country of ref document: ES