PT100075A - Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo - Google Patents

Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo

Info

Publication number
PT100075A
PT100075A PT100075A PT10007592A PT100075A PT 100075 A PT100075 A PT 100075A PT 100075 A PT100075 A PT 100075A PT 10007592 A PT10007592 A PT 10007592A PT 100075 A PT100075 A PT 100075A
Authority
PT
Portugal
Prior art keywords
acyl
perturbactions
hydroxidifosphonics
arilalquil
osteoarticular
Prior art date
Application number
PT100075A
Other languages
English (en)
Other versions
PT100075B (pt
Inventor
Sergio Rosini
Maurizio Mian
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of PT100075A publication Critical patent/PT100075A/pt
Publication of PT100075B publication Critical patent/PT100075B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • C07F9/5728Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3873Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Lubricants (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT100075A 1991-02-01 1992-01-30 Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo PT100075B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910254A IT1244698B (it) 1991-02-01 1991-02-01 Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale

Publications (2)

Publication Number Publication Date
PT100075A true PT100075A (pt) 1993-03-31
PT100075B PT100075B (pt) 1999-06-30

Family

ID=11358376

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100075A PT100075B (pt) 1991-02-01 1992-01-30 Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo

Country Status (20)

Country Link
US (1) US5466682A (pt)
EP (1) EP0569411B1 (pt)
JP (1) JP3046624B2 (pt)
KR (1) KR100190911B1 (pt)
AT (1) ATE120464T1 (pt)
AU (1) AU653780B2 (pt)
CA (1) CA2101548C (pt)
CZ (1) CZ288731B6 (pt)
DE (1) DE69201863T2 (pt)
DK (1) DK0569411T3 (pt)
ES (1) ES2069990T3 (pt)
FI (1) FI105403B (pt)
HK (1) HK1006311A1 (pt)
HU (2) HU215918B (pt)
IT (1) IT1244698B (pt)
MX (1) MX9200452A (pt)
PT (1) PT100075B (pt)
RU (1) RU2079505C1 (pt)
SK (1) SK280053B6 (pt)
WO (1) WO1992013864A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6284748B1 (en) 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530139C3 (de) * 1975-04-30 1979-06-21 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen N-Acyl-1 -aminoalkan-1,1 -diphosphonsäuren, deren Herstellung und Verwendung
DE2651904C2 (de) * 1976-11-13 1983-01-05 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von N-Acyl-N-alkylaminomethandiphosphonsäuren
EP0084822B1 (de) * 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JPH0778024B2 (ja) * 1988-10-14 1995-08-23 藤沢薬品工業株式会社 医薬化合物とジホスホン酸誘導体の結合体を含有する医薬用製剤
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent

Also Published As

Publication number Publication date
FI933231A (fi) 1993-07-16
HU215918B (hu) 1999-03-29
EP0569411B1 (en) 1995-03-29
ITMI910254A0 (it) 1991-02-01
HU9302188D0 (en) 1993-10-28
FI933231A0 (fi) 1993-07-16
US5466682A (en) 1995-11-14
ATE120464T1 (de) 1995-04-15
DE69201863D1 (de) 1995-05-04
ES2069990T3 (es) 1995-05-16
ITMI910254A1 (it) 1992-08-01
RU2079505C1 (ru) 1997-05-20
JPH06504783A (ja) 1994-06-02
FI105403B (fi) 2000-08-15
AU653780B2 (en) 1994-10-13
JP3046624B2 (ja) 2000-05-29
CZ288731B6 (cs) 2001-08-15
SK79993A3 (en) 1993-12-08
MX9200452A (es) 1992-08-01
AU1170992A (en) 1992-09-07
KR100190911B1 (ko) 1999-06-01
CA2101548C (en) 2002-08-27
HUT64964A (en) 1994-03-28
IT1244698B (it) 1994-08-08
DE69201863T2 (de) 1995-09-07
HK1006311A1 (en) 1999-02-19
PT100075B (pt) 1999-06-30
SK280053B6 (sk) 1999-07-12
CA2101548A1 (en) 1992-08-02
CZ153393A3 (en) 1994-01-19
WO1992013864A1 (en) 1992-08-20
HU211203A9 (en) 1995-11-28
DK0569411T3 (da) 1995-08-28
EP0569411A1 (en) 1993-11-18

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