ES2069990T3 - Acido acilaminoalquilidenhidroxibisfosfonico util en la terapia de enfermedades osteoarticulares. - Google Patents

Acido acilaminoalquilidenhidroxibisfosfonico util en la terapia de enfermedades osteoarticulares.

Info

Publication number
ES2069990T3
ES2069990T3 ES92903398T ES92903398T ES2069990T3 ES 2069990 T3 ES2069990 T3 ES 2069990T3 ES 92903398 T ES92903398 T ES 92903398T ES 92903398 T ES92903398 T ES 92903398T ES 2069990 T3 ES2069990 T3 ES 2069990T3
Authority
ES
Spain
Prior art keywords
acilaminoalquilidenhidroxibisfosfonico
therapy
acid useful
osteoarticular diseases
osteoarticular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92903398T
Other languages
English (en)
Inventor
Sergio Rosini
Maurizio Mian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Gentili SpA
Original Assignee
Istituto Gentili SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Gentili SpA filed Critical Istituto Gentili SpA
Application granted granted Critical
Publication of ES2069990T3 publication Critical patent/ES2069990T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Lubricants (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTAN ACIDOS HIDROXIDIFOSFONICOS DE LA FORMULA GENERAL (I), ASI COMO UN PROCESO PARA LA PREPARACION DE LOS MISMOS Y SU USO EN TERAPIAS ANTIINFLAMATORIAS.
ES92903398T 1991-02-01 1992-01-20 Acido acilaminoalquilidenhidroxibisfosfonico util en la terapia de enfermedades osteoarticulares. Expired - Lifetime ES2069990T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910254A IT1244698B (it) 1991-02-01 1991-02-01 Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale

Publications (1)

Publication Number Publication Date
ES2069990T3 true ES2069990T3 (es) 1995-05-16

Family

ID=11358376

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92903398T Expired - Lifetime ES2069990T3 (es) 1991-02-01 1992-01-20 Acido acilaminoalquilidenhidroxibisfosfonico util en la terapia de enfermedades osteoarticulares.

Country Status (20)

Country Link
US (1) US5466682A (es)
EP (1) EP0569411B1 (es)
JP (1) JP3046624B2 (es)
KR (1) KR100190911B1 (es)
AT (1) ATE120464T1 (es)
AU (1) AU653780B2 (es)
CA (1) CA2101548C (es)
CZ (1) CZ288731B6 (es)
DE (1) DE69201863T2 (es)
DK (1) DK0569411T3 (es)
ES (1) ES2069990T3 (es)
FI (1) FI105403B (es)
HK (1) HK1006311A1 (es)
HU (2) HU215918B (es)
IT (1) IT1244698B (es)
MX (1) MX9200452A (es)
PT (1) PT100075B (es)
RU (1) RU2079505C1 (es)
SK (1) SK280053B6 (es)
WO (1) WO1992013864A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
AU6691798A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530139C3 (de) * 1975-04-30 1979-06-21 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen N-Acyl-1 -aminoalkan-1,1 -diphosphonsäuren, deren Herstellung und Verwendung
DE2651904C2 (de) * 1976-11-13 1983-01-05 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von N-Acyl-N-alkylaminomethandiphosphonsäuren
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
EP0084822B1 (de) * 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
EP0243173B1 (en) * 1986-04-24 1991-06-26 Fujisawa Pharmaceutical Co., Ltd. New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JPH0778024B2 (ja) * 1988-10-14 1995-08-23 藤沢薬品工業株式会社 医薬化合物とジホスホン酸誘導体の結合体を含有する医薬用製剤
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent

Also Published As

Publication number Publication date
ITMI910254A1 (it) 1992-08-01
CZ288731B6 (cs) 2001-08-15
IT1244698B (it) 1994-08-08
HUT64964A (en) 1994-03-28
ATE120464T1 (de) 1995-04-15
JP3046624B2 (ja) 2000-05-29
HU215918B (hu) 1999-03-29
EP0569411B1 (en) 1995-03-29
DE69201863D1 (de) 1995-05-04
HU211203A9 (en) 1995-11-28
PT100075A (pt) 1993-03-31
CA2101548A1 (en) 1992-08-02
AU653780B2 (en) 1994-10-13
ITMI910254A0 (it) 1991-02-01
PT100075B (pt) 1999-06-30
FI933231A0 (fi) 1993-07-16
AU1170992A (en) 1992-09-07
HU9302188D0 (en) 1993-10-28
SK79993A3 (en) 1993-12-08
WO1992013864A1 (en) 1992-08-20
RU2079505C1 (ru) 1997-05-20
MX9200452A (es) 1992-08-01
SK280053B6 (sk) 1999-07-12
JPH06504783A (ja) 1994-06-02
HK1006311A1 (en) 1999-02-19
EP0569411A1 (en) 1993-11-18
US5466682A (en) 1995-11-14
FI933231A (fi) 1993-07-16
CZ153393A3 (en) 1994-01-19
DE69201863T2 (de) 1995-09-07
KR100190911B1 (ko) 1999-06-01
DK0569411T3 (da) 1995-08-28
CA2101548C (en) 2002-08-27
FI105403B (fi) 2000-08-15

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