ITMI910254A1 - Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale - Google Patents
Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generaleInfo
- Publication number
- ITMI910254A1 ITMI910254A1 IT000254A ITMI910254A ITMI910254A1 IT MI910254 A1 ITMI910254 A1 IT MI910254A1 IT 000254 A IT000254 A IT 000254A IT MI910254 A ITMI910254 A IT MI910254A IT MI910254 A1 ITMI910254 A1 IT MI910254A1
- Authority
- IT
- Italy
- Prior art keywords
- hydroxidyphosphonic
- alchyl
- osteo
- arylalkyl
- aryl
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 210000002808 connective tissue Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 3
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Lubricants (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI910254A IT1244698B (it) | 1991-02-01 | 1991-02-01 | Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale |
| CA002101548A CA2101548C (en) | 1991-02-01 | 1992-01-20 | Acylamino-alkylidenhydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases |
| JP4503474A JP3046624B2 (ja) | 1991-02-01 | 1992-01-20 | 骨関節症の治療に用いるアシルアルミノ−アルキリデン−ヒドロキシ−ビスホスホン酸 |
| DE69201863T DE69201863T2 (de) | 1991-02-01 | 1992-01-20 | Acylaminoalkylidenhydroxybisphosphonsäure brauchbar in der Therapie von osteoartikularen Krankheiten. |
| PCT/EP1992/000102 WO1992013864A1 (en) | 1991-02-01 | 1992-01-20 | Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases |
| KR1019930702242A KR100190911B1 (ko) | 1991-02-01 | 1992-01-20 | 골관절질환의치료에유용한아실아미노-알킬리덴-히드록시-비스포스폰산 |
| ES92903398T ES2069990T3 (es) | 1991-02-01 | 1992-01-20 | Acido acilaminoalquilidenhidroxibisfosfonico util en la terapia de enfermedades osteoarticulares. |
| AT92903398T ATE120464T1 (de) | 1991-02-01 | 1992-01-20 | Acylaminoalkylidenhydroxybisphosphonsäure brauchbar in der therapie von osteoartikularen krankheiten. |
| RU9293052408A RU2079505C1 (ru) | 1991-02-01 | 1992-01-20 | N-ациламино-1-гидроксиалкилиден-1,1-бисфосфоновые кислоты и способ их получения |
| SK799-93A SK280053B6 (sk) | 1991-02-01 | 1992-01-20 | Acylamino-alkylidén-hydroxybisfosfónové kyseliny, |
| CZ19931533A CZ288731B6 (cs) | 1991-02-01 | 1992-01-20 | Acylaminoalkylidenhydroxybisfosfonové kyseliny a farmaceutické prostředky s jejich obsahem |
| US08/094,160 US5466682A (en) | 1991-02-01 | 1992-01-20 | Acylamino-alkyliden-hydroxy-bisphosphonic acids esters and salts thereof, wherein the acyl group is derived from an acid having antiinflammatory activity |
| AU11709/92A AU653780B2 (en) | 1991-02-01 | 1992-01-20 | Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases |
| DK92903398.3T DK0569411T3 (da) | 1991-02-01 | 1992-01-20 | Acylaminoalkylidenhydroxybiphosphonsyrer anvendelige til behandling af osteoartikulære sygdomme |
| HU9801273A HU217588B (hu) | 1991-02-01 | 1992-01-20 | Acil-amino-alkilidén-hidroxi-bifoszfonsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények |
| HU9302188A HU215918B (hu) | 1991-02-01 | 1992-01-20 | Eljárás acil-amino-alkilidén-hidroxi-bifoszfonsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására |
| EP92903398A EP0569411B1 (en) | 1991-02-01 | 1992-01-20 | Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases |
| PT100075A PT100075B (pt) | 1991-02-01 | 1992-01-30 | Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo |
| MX9200452A MX9200452A (es) | 1991-02-01 | 1992-01-31 | Acidos aril o arilalquil-acil-amino-alquil-hidroxidifosfonicos, un procedimiento para su preparacion y su uso en la terapia de trastornos ostearticulares y del tejido conectivo. |
| FI933231A FI105403B (fi) | 1991-02-01 | 1993-07-16 | Analogiamenetelmä lääkeaineina käyttökelpoisten asyyliamino-alkylideeni-hydroksi-bisfosfonihappojen valmistamiseksi |
| HU95P/P00154P HU211203A9 (en) | 1991-02-01 | 1995-06-02 | Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases |
| HK98105383A HK1006311A1 (en) | 1991-02-01 | 1998-06-16 | Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI910254A IT1244698B (it) | 1991-02-01 | 1991-02-01 | Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI910254A0 ITMI910254A0 (it) | 1991-02-01 |
| ITMI910254A1 true ITMI910254A1 (it) | 1992-08-01 |
| IT1244698B IT1244698B (it) | 1994-08-08 |
Family
ID=11358376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI910254A IT1244698B (it) | 1991-02-01 | 1991-02-01 | Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5466682A (it) |
| EP (1) | EP0569411B1 (it) |
| JP (1) | JP3046624B2 (it) |
| KR (1) | KR100190911B1 (it) |
| AT (1) | ATE120464T1 (it) |
| AU (1) | AU653780B2 (it) |
| CA (1) | CA2101548C (it) |
| CZ (1) | CZ288731B6 (it) |
| DE (1) | DE69201863T2 (it) |
| DK (1) | DK0569411T3 (it) |
| ES (1) | ES2069990T3 (it) |
| FI (1) | FI105403B (it) |
| HK (1) | HK1006311A1 (it) |
| HU (2) | HU215918B (it) |
| IT (1) | IT1244698B (it) |
| MX (1) | MX9200452A (it) |
| PT (1) | PT100075B (it) |
| RU (1) | RU2079505C1 (it) |
| SK (1) | SK280053B6 (it) |
| WO (1) | WO1992013864A1 (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6452098A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| AU6691798A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2530139C3 (de) * | 1975-04-30 | 1979-06-21 | Joh. A. Benckiser Gmbh, 6700 Ludwigshafen | N-Acyl-1 -aminoalkan-1,1 -diphosphonsäuren, deren Herstellung und Verwendung |
| DE2651904C2 (de) * | 1976-11-13 | 1983-01-05 | Joh. A. Benckiser Gmbh, 6700 Ludwigshafen | Verfahren zur Herstellung von N-Acyl-N-alkylaminomethandiphosphonsäuren |
| DE3203308A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| EP0084822B1 (de) * | 1982-01-27 | 1986-01-08 | Schering Aktiengesellschaft | Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| DE3512536A1 (de) * | 1985-04-06 | 1986-10-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| EP0243173B1 (en) * | 1986-04-24 | 1991-06-26 | Fujisawa Pharmaceutical Co., Ltd. | New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| JPH0778024B2 (ja) * | 1988-10-14 | 1995-08-23 | 藤沢薬品工業株式会社 | 医薬化合物とジホスホン酸誘導体の結合体を含有する医薬用製剤 |
| PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
| US5159108A (en) * | 1990-09-18 | 1992-10-27 | Merck & Co., Inc. | Process for preparing an antihypercalcemic agent |
-
1991
- 1991-02-01 IT ITMI910254A patent/IT1244698B/it active IP Right Grant
-
1992
- 1992-01-20 JP JP4503474A patent/JP3046624B2/ja not_active Expired - Fee Related
- 1992-01-20 CA CA002101548A patent/CA2101548C/en not_active Expired - Fee Related
- 1992-01-20 SK SK799-93A patent/SK280053B6/sk unknown
- 1992-01-20 ES ES92903398T patent/ES2069990T3/es not_active Expired - Lifetime
- 1992-01-20 DE DE69201863T patent/DE69201863T2/de not_active Expired - Fee Related
- 1992-01-20 KR KR1019930702242A patent/KR100190911B1/ko not_active IP Right Cessation
- 1992-01-20 DK DK92903398.3T patent/DK0569411T3/da active
- 1992-01-20 AT AT92903398T patent/ATE120464T1/de not_active IP Right Cessation
- 1992-01-20 CZ CZ19931533A patent/CZ288731B6/cs not_active IP Right Cessation
- 1992-01-20 EP EP92903398A patent/EP0569411B1/en not_active Expired - Lifetime
- 1992-01-20 RU RU9293052408A patent/RU2079505C1/ru active
- 1992-01-20 HU HU9302188A patent/HU215918B/hu not_active IP Right Cessation
- 1992-01-20 US US08/094,160 patent/US5466682A/en not_active Expired - Lifetime
- 1992-01-20 AU AU11709/92A patent/AU653780B2/en not_active Ceased
- 1992-01-20 WO PCT/EP1992/000102 patent/WO1992013864A1/en active IP Right Grant
- 1992-01-30 PT PT100075A patent/PT100075B/pt not_active IP Right Cessation
- 1992-01-31 MX MX9200452A patent/MX9200452A/es unknown
-
1993
- 1993-07-16 FI FI933231A patent/FI105403B/fi active
-
1995
- 1995-06-02 HU HU95P/P00154P patent/HU211203A9/hu unknown
-
1998
- 1998-06-16 HK HK98105383A patent/HK1006311A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ288731B6 (cs) | 2001-08-15 |
| IT1244698B (it) | 1994-08-08 |
| HUT64964A (en) | 1994-03-28 |
| ATE120464T1 (de) | 1995-04-15 |
| JP3046624B2 (ja) | 2000-05-29 |
| HU215918B (hu) | 1999-03-29 |
| EP0569411B1 (en) | 1995-03-29 |
| DE69201863D1 (de) | 1995-05-04 |
| HU211203A9 (en) | 1995-11-28 |
| PT100075A (pt) | 1993-03-31 |
| CA2101548A1 (en) | 1992-08-02 |
| AU653780B2 (en) | 1994-10-13 |
| ITMI910254A0 (it) | 1991-02-01 |
| PT100075B (pt) | 1999-06-30 |
| FI933231A0 (fi) | 1993-07-16 |
| AU1170992A (en) | 1992-09-07 |
| HU9302188D0 (en) | 1993-10-28 |
| SK79993A3 (en) | 1993-12-08 |
| ES2069990T3 (es) | 1995-05-16 |
| WO1992013864A1 (en) | 1992-08-20 |
| RU2079505C1 (ru) | 1997-05-20 |
| MX9200452A (es) | 1992-08-01 |
| SK280053B6 (sk) | 1999-07-12 |
| JPH06504783A (ja) | 1994-06-02 |
| HK1006311A1 (en) | 1999-02-19 |
| EP0569411A1 (en) | 1993-11-18 |
| US5466682A (en) | 1995-11-14 |
| FI933231A (fi) | 1993-07-16 |
| CZ153393A3 (en) | 1994-01-19 |
| DE69201863T2 (de) | 1995-09-07 |
| KR100190911B1 (ko) | 1999-06-01 |
| DK0569411T3 (da) | 1995-08-28 |
| CA2101548C (en) | 2002-08-27 |
| FI105403B (fi) | 2000-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970226 |