ATE181333T1 - Azirdin-derivate, deren herstellung und verwendung - Google Patents
Azirdin-derivate, deren herstellung und verwendungInfo
- Publication number
- ATE181333T1 ATE181333T1 AT95915310T AT95915310T ATE181333T1 AT E181333 T1 ATE181333 T1 AT E181333T1 AT 95915310 T AT95915310 T AT 95915310T AT 95915310 T AT95915310 T AT 95915310T AT E181333 T1 ATE181333 T1 AT E181333T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- sec
- hydrocarbon residue
- date
- azirdine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7462194 | 1994-04-13 | ||
JP26917594 | 1994-11-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE181333T1 true ATE181333T1 (de) | 1999-07-15 |
Family
ID=26415785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95915310T ATE181333T1 (de) | 1994-04-13 | 1995-04-12 | Azirdin-derivate, deren herstellung und verwendung |
Country Status (7)
Country | Link |
---|---|
US (1) | US5668128A (de) |
EP (1) | EP0753003B1 (de) |
AT (1) | ATE181333T1 (de) |
AU (1) | AU2223595A (de) |
CA (1) | CA2187451A1 (de) |
DE (1) | DE69510338T2 (de) |
WO (1) | WO1995028416A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK56798A3 (en) | 1995-10-30 | 1998-12-02 | Smithkline Beecham Corp | Protease inhibitors, pharmaceutical composition containing them and their use |
US6586466B2 (en) | 1995-10-30 | 2003-07-01 | Smithkline Beecham Corporation | Carbohydrazide-protease inhibitors |
EA199700087A1 (ru) * | 1995-10-30 | 1998-04-30 | Смитклайн Бичам Корпорейшн | Способ ингибирования катепсина к |
WO1998008802A1 (en) * | 1996-08-28 | 1998-03-05 | Smithkline Beecham Corporation | Inhibitors of cysteine protease |
US20030044399A1 (en) * | 1998-12-23 | 2003-03-06 | Smithkline Beecham Corporation | Method of treatment |
US20030144175A1 (en) * | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
WO2000061785A2 (en) * | 1999-04-14 | 2000-10-19 | Smithkline Beecham Corporation | Polynucleotide and polypeptide sequences of monkey cathepsin k |
JP2003513972A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
JP2003513924A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
AU1588901A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
SK13632002A3 (sk) * | 2000-03-21 | 2003-02-04 | Smithkline Beecham Corporation | C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty |
US20040038965A1 (en) * | 2001-10-09 | 2004-02-26 | Marquis, Jr. Robert W. | Protease inhibitors |
DE102005024040A1 (de) * | 2005-05-25 | 2006-12-14 | Rovi Gmbh & Co. Kosmetische Rohstoffe Kg | Kosmetisches oder therapeutisches Kombinationspräparat mit Theanin |
EP4140542A1 (de) * | 2021-08-24 | 2023-03-01 | Centre National De La Recherche Scientifique (Cnrs) | Neue vashs-inhibitoren, konjugate davon und deren verwendungen als arzneimittel oder als forschungswerkzeuge |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55153778A (en) * | 1979-05-17 | 1980-11-29 | Taisho Pharmaceut Co Ltd | Epoxysuccinylamino acid derivative |
EP0269311A3 (de) * | 1986-11-17 | 1990-06-06 | Merck & Co. Inc. | Methoden zur Behandlung von Knochenleiden mittels Verabreichung von Cystein-Proteinaseinhibitoren |
DE4142958A1 (de) * | 1991-12-24 | 1993-07-01 | Univ Halle Wittenberg | Inhibitoren zur hemmung der katalytischen aktivitaet von prolinspezifischen und anderen enzymen |
-
1995
- 1995-04-12 DE DE69510338T patent/DE69510338T2/de not_active Expired - Fee Related
- 1995-04-12 WO PCT/JP1995/000718 patent/WO1995028416A1/en active IP Right Grant
- 1995-04-12 EP EP95915310A patent/EP0753003B1/de not_active Expired - Lifetime
- 1995-04-12 CA CA002187451A patent/CA2187451A1/en not_active Abandoned
- 1995-04-12 US US08/513,896 patent/US5668128A/en not_active Expired - Fee Related
- 1995-04-12 AT AT95915310T patent/ATE181333T1/de not_active IP Right Cessation
- 1995-04-12 AU AU22235/95A patent/AU2223595A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US5668128A (en) | 1997-09-16 |
DE69510338T2 (de) | 1999-10-14 |
DE69510338D1 (de) | 1999-07-22 |
EP0753003B1 (de) | 1999-06-16 |
CA2187451A1 (en) | 1995-10-26 |
EP0753003A1 (de) | 1997-01-15 |
WO1995028416A1 (en) | 1995-10-26 |
AU2223595A (en) | 1995-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |