KR910002775A - 방향족 카복실산 아미드 - Google Patents

방향족 카복실산 아미드 Download PDF

Info

Publication number
KR910002775A
KR910002775A KR1019900011436A KR900011436A KR910002775A KR 910002775 A KR910002775 A KR 910002775A KR 1019900011436 A KR1019900011436 A KR 1019900011436A KR 900011436 A KR900011436 A KR 900011436A KR 910002775 A KR910002775 A KR 910002775A
Authority
KR
South Korea
Prior art keywords
tetramethyl
tetrahydro
compound
benzamide
hydroxy
Prior art date
Application number
KR1019900011436A
Other languages
English (en)
Inventor
클라우스 미카엘
모르 페터
Original Assignee
쟝-자크 오게이
에프.호프만-라 롯슈 아크티엔게젤샤프트
롤란드 보러
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쟝-자크 오게이, 에프.호프만-라 롯슈 아크티엔게젤샤프트, 롤란드 보러 filed Critical 쟝-자크 오게이
Publication of KR910002775A publication Critical patent/KR910002775A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

방향족 카복실산 아미드
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. 하기 일반식 (I)의 화합물;
    상기식에서 R1은 수소, 할로겐 또는 OR5(여기에서, R5는 수소, 아실, 저급-알콕시카보닐 또는 저급-알킬을 나타내며, 이들은 아미노, 모노-알킬 아미노, 디알킬아미노 또는 잔기-N-Het 에 의해 치환될 수 있고, -N-Het는 N원자를 통해 부착된, 5 내지 8원의 포화 또는 불포화 모노사이클릭 헤테로사이클을 나타낸다)를 나타내고; R2는 수소, 저급-알킬, 저급-알콕시 또는 할로겐을 타나내며; R3및 R4는 각각 독립적으로 저급-알킬을 나타내거나 또는 함께는 직쇄내에 3개 내지 5개의 C원자를 갖는 알킬렌을 나타내고; M은 -CONH- 또는 -NHCO-를 나타낸다.
  2. 제1항에 있어서, R3및 R4가 함께 직쇄내에 3개 내지 5개의 C원자를 갖는 알킬렌을 나타내는 화합물.
  3. 제2항에 있어서, R3및 R4가 함께 잔기 -C(CH3)2-CH2-C(CH3)2-, -C(CH3)2-CH2CH2-C(CH3)2-또는 -CH2CH2-C(CH3)2-CH2CH2-를 나타내는 화합물.
  4. 제1항 내지 제3항에 있어서, R1이 수소, 하이드록시, 불소, 모르폴리노에톡시 또는 N-메틸피페리디노에톡시인 화합물.
  5. 제1항 내지 제4항에 있어서, M이 -CONH-인 화합물.
  6. 5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-4'-(2-모르폴리노에톡시)-2-나프탈렌카복스아닐리드.
  7. 5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-4'-하이드록시-2-나프탈렌카복스아닐리드.
  8. 화합물 5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프탈렌카복스아닐리드; 4'-플루오로-5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프탈렌카복스아닐리드; 1,1,3,3,-테트라메틸-5-인단카복스아닐리드; 4'-플루오로-1,1,3,3,-테트라메틸-5-인단카복스아닐리드; 1,1,3,3,-테트라메틸-4'-(2-모르폴리노에톡시)-5-인단 카복스아닐리드; 4'-하이드록시-1,1,3,3,-테트라메틸-5-인단카복스아닐리드; 6,7,8,9-테트라하이드로-7,7-디메틸-5H-벤조사이클로 헵텐-2-카복실산(4-하이드록시) 아닐리드; 6,7,8,9-테트라하이드로-7,7-디메틸-5H-벤조사이클로 헵텐-2-카복실산(4-플루 오로) 아닐리드; 6,7,8,9-테트라하이드로-7,7-디메틸-5H-벤조사이클로 헵텐-2-카복스아닐리드.
  9. 제1항 내지 제4항에 있어서, M이 -NHCO-인 화합물.
  10. (5.6.7.8-테트라하이드로-5.5.8.8-테트라메틸-2-나프틸)-4-하이드록시벤즈아미드.
  11. (5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프틸)벤즈아미드; p-플루오로-N-(5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프틸)벤즈아미드; p-(2-모르폴리노메톡시)-N-(5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프틸)벤즈아미드.
  12. 화합물 N-(1,1,3,3-테트라메틸-5-인단일)벤즈아미드; p-플루오로-N-(1,1,3,3-테트라메틸-5-인단일)벤즈아미드; p-(2-모르폴리노메톡시)-N-(1,1,3,3-테트라메틸-5-인단일)벤즈아미드; p-하이드로시-N-(1,1,3,3-테트라메틸-5-인단일)벤즈아미드; 6,7,8,9-테트라하이드로-9,9-디메틸-5H-벤조사이클로헵텐-2-카복실산(4-하이드록시)아닐리드; 6,7,8,9-테트라하이드로-9,9-디메틸-5H-벤조사이클로 헵텐-2-카복실산(4-플루오로)아닐리드; 3-에틸-6,7,8,9-테트라하이드로-7,7-디메틸-5H-벤조사이클로 헵텐-2-카복실산(4-하이드록시) 아닐리드.
  13. 약제로서 사용하기 위한 일반식(I)의 화합물.
  14. 하기 일반식(Ⅱ)의 화합물과 하기 일반식(Ⅲ)의 화합물을 반응시키고, 그후에 존재할 수 있는 아미노 보호 그룹을 분해제거함을 포함하는 제1항의 화합물의 제조방법.
    상기식에서, A는 카복실 그룹 또는 그의 반응성 유도체를 나타내고 B는 아미노 그룹을 나타내거나 또는, A는 아미노 그룹을 나타내고 B는 카복실 그룹 또는 그의 반응성 유도체를 나타내며, R11은 존재할수 있는 아미노 그룹이 보호된 형태인 잔기 R1을 나타낸다.
  15. 일반식(I)의 화합물 및 통상의 담체 물질과 보조제를 함유하는 약학 제제.
  16. 종양과 피부병, 피부노화 및 류마티스성 질병과 면역학적 질병 치료용 약학 제제의 제조를 위한 일반식(I) 화합물의 용도.
  17. 제1항의 방법 또는 그와 명백하게 동등한 화학적 방법에 의해 제조된 제1항의 일반식(I)의 화합물.
  18. 본 명세서, 특히 실시예에 기재된 바와 실질적으로 같은 신규한 화합물, 제제 및 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900011436A 1989-07-28 1990-07-27 방향족 카복실산 아미드 KR910002775A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH281889 1989-07-28
CH2818/89 1989-07-28

Publications (1)

Publication Number Publication Date
KR910002775A true KR910002775A (ko) 1991-02-26

Family

ID=4242276

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900011436A KR910002775A (ko) 1989-07-28 1990-07-27 방향족 카복실산 아미드

Country Status (27)

Country Link
US (1) US5128470A (ko)
EP (1) EP0410358B1 (ko)
JP (1) JPH075533B2 (ko)
KR (1) KR910002775A (ko)
AR (1) AR247550A1 (ko)
AT (1) ATE95167T1 (ko)
AU (1) AU637623B2 (ko)
CA (1) CA2020887A1 (ko)
CZ (1) CZ277709B6 (ko)
DE (1) DE59002899D1 (ko)
DK (1) DK0410358T3 (ko)
ES (1) ES2059919T3 (ko)
FI (1) FI903740A0 (ko)
HU (1) HU204773B (ko)
IE (1) IE902734A1 (ko)
IL (1) IL95144A (ko)
IS (1) IS3611A7 (ko)
MC (1) MC2135A1 (ko)
MX (1) MX21691A (ko)
MY (1) MY106704A (ko)
NO (1) NO903351L (ko)
NZ (1) NZ234595A (ko)
PH (1) PH27297A (ko)
PT (1) PT94839A (ko)
RU (1) RU1811525C (ko)
YU (1) YU141690A (ko)
ZA (1) ZA905738B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617020A1 (en) * 1992-04-02 1994-09-28 Shudo, Koichi, Prof. Dr. Carboxylic acid derivatives having retinoic acid-like activity
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
FR2759368B1 (fr) * 1997-02-10 2001-06-01 Galderma Rech Dermatologique Composes biaromatiques, compositions les contenant et utilisations
US6664293B2 (en) * 1999-02-26 2003-12-16 Fujiwawa Pharmaceutical Co., Ltd. Amide compounds for the potentiation of cholinergic activity
TR200102568T2 (tr) * 1999-03-17 2002-05-21 Astrazeneca Ab Amid türevleri.
US6316475B1 (en) * 2000-11-17 2001-11-13 Abbott Laboratories Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
RU2419602C2 (ru) 2003-08-06 2011-05-27 Синомикс Инк. Новые ароматизирующие вещества, модификаторы вкуса, соединения, придающие вкус, усилители вкуса, соединения, придающие вкус "умами" или сладкий вкус, и/или усилители и их применение
US20090247590A1 (en) * 2004-10-15 2009-10-01 Bayer Pharmaceuticlas Corporation Indane amides
US20100158829A1 (en) * 2008-12-24 2010-06-24 Conopco, Inc., D/B/A Unilever Method and Composition for Color Modulation
US8653299B2 (en) 2011-03-17 2014-02-18 Allergan, Inc. Dihydronaphthalene and naphthalene derivatives as N-formyl peptide receptor like-1 (FPRL-1) receptor modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3202100A1 (de) * 1982-01-23 1983-08-04 Basf Ag, 6700 Ludwigshafen Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
JPS58140054A (ja) * 1982-02-10 1983-08-19 Sumitomo Chem Co Ltd インダニルベンツアミド誘導体、その製造法およびこれらを有効成分として含有する農園芸用殺菌剤
DE3580134D1 (de) * 1984-07-07 1990-11-22 Shudo Koichi Prof Dr Chem Benzoesaeurederivate.
LU86258A1 (fr) * 1986-01-21 1987-09-03 Rech Dermatologiques C I R D S Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
GB8617653D0 (en) * 1986-07-18 1986-08-28 Ici Plc Amide derivatives
US4808631A (en) * 1986-11-07 1989-02-28 Hoffmann-La Roche Inc. Aromatic acid derivatives
US4992576A (en) * 1987-01-12 1991-02-12 Eli Lilly And Company Intermediates for leukotriene antagonists
CA1320490C (en) 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
JPS6471843A (en) * 1987-09-11 1989-03-16 Meiji Seika Kaisha Novel substituted benzoic acid anilide derivative and plant disease injury controlling agent containing said derivative as active ingredient

Also Published As

Publication number Publication date
MC2135A1 (fr) 1992-01-14
MY106704A (en) 1995-07-31
JPH075533B2 (ja) 1995-01-25
RU1811525C (ru) 1993-04-23
NO903351D0 (no) 1990-07-27
IL95144A (en) 1994-10-07
ES2059919T3 (es) 1994-11-16
EP0410358B1 (de) 1993-09-29
ATE95167T1 (de) 1993-10-15
IL95144A0 (en) 1991-06-10
IE902734A1 (en) 1991-02-27
US5128470A (en) 1992-07-07
IS3611A7 (is) 1991-01-29
PH27297A (en) 1993-05-04
MX21691A (es) 1993-10-01
HUT54106A (en) 1991-01-28
HU204773B (en) 1992-02-28
DE59002899D1 (de) 1993-11-04
CS374090A3 (en) 1992-01-15
FI903740A0 (fi) 1990-07-26
AU637623B2 (en) 1993-06-03
DK0410358T3 (da) 1993-12-13
YU141690A (sh) 1993-05-28
EP0410358A1 (de) 1991-01-30
ZA905738B (en) 1991-03-27
NO903351L (no) 1991-01-29
PT94839A (pt) 1991-03-20
CA2020887A1 (en) 1991-01-29
NZ234595A (en) 1992-10-28
HU904577D0 (en) 1990-12-28
CZ277709B6 (en) 1993-03-17
AU5989290A (en) 1991-01-31
JPH0374353A (ja) 1991-03-28
AR247550A1 (es) 1995-01-31

Similar Documents

Publication Publication Date Title
RU94036758A (ru) Применение 2-фенил-3-ароилбензотиофенов для лечения пери-менопаузного синдрома
ATE113834T1 (de) Zusammensetzung zur behandlung der schizophrenie.
BR9612423A (pt) Composto, composição farmacêutica, e, processo para tratar um estado doentio.
RU96117041A (ru) Применение производных 2-гидрокси-5-фенилазобензойной кислоты в качестве химиопрофилактических и химиотерапевтических агентов при раке ободочной кишки
ATE63124T1 (de) Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung.
DE69204084T2 (de) Glycyl-Serine Amide und diese enthaltende kosmetische und pharmazeutische Zusammensetzungen oder Röhrmittel.
JPS5513275A (en) Prodrug of non-steroid anti-inflammatory drug having improved absorption and anti-inflammatory drug composition comprising it
KR870005973A (ko) 항염증성 및 진통성의 활성을 갖는 벤조산 및 벤조산 에스테르의 유도체
KR910002775A (ko) 방향족 카복실산 아미드
EP0472501A3 (en) Codeinsalt of a substituted carbonacid, process of its preparation, its use and pharmaceutical preparations
KR890011596A (ko) 불면증 치료용 의약품의 제조에 있어서 1,4-이치환-피페리디닐 화합물의 용도
RU94036771A (ru) Ингибиторы ангиогенеза и ангиогенных заболеваний
KR900004658A (ko) 이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제
RU94037246A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования разрушения хряща
RU94046141A (ru) Замещенные производные /арилалкоксибензил/ аминопропанамида, способы их получения, фармацевтическая композиция
KR900011724A (ko) 특정 피롤릴페닐-치환된 하이드록삼산 유도체
ES528462A0 (es) Procedimiento de preparacion de nuevos derivados dialquilaminoalcoxibencilalcoholicos y de sus sales de adicion acidas y amonicas cuaternarias
DE68912811D1 (de) Amide von Cyclomethylen-1,2 bicarbonsäure mit therapeutischer Wirkung, Verfahren zu deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen.
ATE110568T1 (de) Pharmazeutisches präparat zur behandlung des katarakts.
ES2059388T3 (es) N-(2-(4-carboximetoxifenil)-1-metiletil)-2-hidroxi-2-(3-clorofenil)etanamina, el ester metilico, la sal y los estereoisomeros de los mismos.
FR2455590A1 (fr) Nouveaux derives d'acide 2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoique, utiles notamment comme agents bloquants des recepteurs a- et b-adrenergiques, et leur procede de preparation
RU97108129A (ru) Нитробензамиды, применимые в качестве антиаритмических средств
ITMI910658A1 (it) N-(4, 5-diidrossi-e 4, 5, 8-triidrossi-9, 10-diidro-9, 10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari
KR890012961A (ko) N-(저급알킬)-2-(3'-우레이도벤질)피롤리딘
KR940021524A (ko) 1,2,5,6-테트라하이드로피리딘 유도체와 이의 제조 방법 및 치료시 이의 이용방법

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid