KR870005973A - 항염증성 및 진통성의 활성을 갖는 벤조산 및 벤조산 에스테르의 유도체 - Google Patents

항염증성 및 진통성의 활성을 갖는 벤조산 및 벤조산 에스테르의 유도체 Download PDF

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Publication number
KR870005973A
KR870005973A KR860010989A KR860010989A KR870005973A KR 870005973 A KR870005973 A KR 870005973A KR 860010989 A KR860010989 A KR 860010989A KR 860010989 A KR860010989 A KR 860010989A KR 870005973 A KR870005973 A KR 870005973A
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South Korea
Prior art keywords
compound
carboxybenzyl
pharmaceutically acceptable
formula
benzoic acid
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KR860010989A
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English (en)
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KR900006749B1 (ko
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존슨 그라함
에프·라페르티 미첼
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크리스틴 에이. 트라우트웨인
워너-램버트 캄퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

항염증성 및 진통성의 활성을 갖는 벤조산 및 벤조산 에스테르의 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (29)

  1. 식중 B가 (B1)이고 Q가 H일때, R1은 메틸렌이 아니고, B가(B2)일때 Q는 CH3,H, 또는 페닐이될 수 없는 것을 전제로 한 다음 일반식의 화합물; 또는 비독성이고, 제약학적으로 허용 가능한 당해 산 부가염 또는 염기염.
  2. 제1항에 있어서, 식중 R1이 COOH이고, X, Y, B, R2및 Q가 전술한 바와 같은 다음 일반식의 화합물.
  3. 제2항에 있어서, 식중 B가 B1인 화합물.
  4. 제3항에 있어서, R2가 C3-11직쇄 또는 분지쇄 알킬렌인 화합물.
  5. 제3항에 있어서, X가 메틸이고, Y가 수소이고, B, B2및 Q가 전술한 바와 같은 화합물
  6. 제3항에 있어서, X가 수소이고, Y가 메틸이고, B, R2및 Q가 전술한 바와 같은 화합물.
  7. 제4항에 있어서, N-(4-카복시벤질)헵탄아미드인 화합물.
  8. 제4항에 있어서, N-(4-카복시벤질)노난아미드인 화합물.
  9. 제4항에 있어서, N-(4-카복시벤질)데칸아미드 또는 당해 나트륨 염인 화합물.
  10. 제4항에 있어서, N-(4-카복시벤질)옥탄아미드인 화합물.
  11. 제4항에 있어서, N-(4-카복시벤질)부티르아미드인 화합물.
  12. 제4항에 있어서, N-(4-카복시벤질)헥산아미드인 화합물.
  13. 제4항에 있어서, N-(4-카복시벤질)운 데칸아미드인 화합물.
  14. 제5항에 있어서, N-1-[1-(4-카복시페닐)에틸]노난아미드인 화합물.
  15. 제6항에 있어서, N-(4-카복시벤질)-N-메틸노난 아미드인 화합물.
  16. 제3항에 있어서, X 및 Y가 각각 H이고, R2가 C1-3직쇄 또는 분지쇄 알킬렌 또는 알케닐렌이 고, Q가
    인 화합물.
  17. 제16항에 있어서, N-(4-카복시벤질)페닐아세트아미드인 화합물.
  18. 제16항에 있어서, N-(4-카복시벤질)-4-하이드록시-3-메톡시신남아미드인 화합물.
  19. 제16항에 있어서, N-(4-카복시벤질)신남아미드인 화합물.
  20. 제16항에 있어서, N-(4-카복시벤질)-4-페닐부티르아미드인 화합물.
  21. 제16항에 있어서, N-(4-카복시벤질)-4-사이클로헥실아세트아미드인 화합물.
  22. 제16항에 있어서, N-(4-카복시벤질)-2-나프톡시아세트아미드인 화합물.
  23. 제1항에 있어서, R1이 테르라졸릴인 화합물.
  24. 제23항에 있어서, N-[[4-(1H-테트라졸-5-일)페닐]메틸]노난아미드인 화합물.
  25. 효용량의 다음 일반식의 화합물 또는 비독성이고, 제약학적으로 허용 가능한 당해 산 부가염 또는 염기염; 및 제약학적으로 허용 가능한 담체로 구성된 제악학적 조성물.
  26. 염증으로 고통받는 포유동물에 효용량의 제 25항에 따른 제약학적 조성물을 그러한 포유동물에 투약하는 것으로 구성되는 염증을 감소시키는 방법.
  27. 통증으로 고통받는 포유동물에 진통제로 효용량의 제 26항에 따른 제약학적 조성물을 투약하는 것으로 구성되는 통증을 치료하는 방법.
  28. 두통으로 고통받는 포유동물에 두통치료제로 효용량의 제 25항에 따른 제약학적 조성물을 투약하는 것으로 구성되는 두통을 치료하는 방법.
  29. 식중 Hal이 브롬, 염소 또는 요오드이고 A,R1,X,Y,B,R2및 Q가 전술한 바와 같은 다음 일반식의 화합물및 Hal--R2-Q을 반응시켜 일반식(1)의 화합물을 얻고, 아울러 일반식(1)의 화합물을 반응시켜 비독성이고 제약학적을 허용 가능한 당해 염을 얻는 것으로 구성되는 제1항 화합물의 제조 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860010989A 1985-12-20 1986-12-20 항염증성 및 진통성의 활성을 갖는 벤조산 및 벤조산 에스테르의 유도체 KR900006749B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US811,567 1985-12-20
US06/811,567 US4689182A (en) 1985-12-20 1985-12-20 Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity

Publications (2)

Publication Number Publication Date
KR870005973A true KR870005973A (ko) 1987-07-08
KR900006749B1 KR900006749B1 (ko) 1990-09-20

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Application Number Title Priority Date Filing Date
KR1019860010989A KR900006749B1 (ko) 1985-12-20 1986-12-20 항염증성 및 진통성의 활성을 갖는 벤조산 및 벤조산 에스테르의 유도체

Country Status (14)

Country Link
US (1) US4689182A (ko)
EP (1) EP0226223A3 (ko)
JP (1) JPS62155246A (ko)
KR (1) KR900006749B1 (ko)
CN (1) CN86108626A (ko)
AU (1) AU605123B2 (ko)
CA (1) CA1277326C (ko)
DK (1) DK604886A (ko)
FI (1) FI865108A (ko)
NO (1) NO865204L (ko)
NZ (1) NZ218588A (ko)
PH (1) PH23355A (ko)
PT (1) PT83974B (ko)
ZA (1) ZA869014B (ko)

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CN103864638B (zh) * 2012-12-14 2015-12-09 沈阳药科大学 一种苯甲酸类化合物及其制备方法和应用

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Also Published As

Publication number Publication date
DK604886A (da) 1987-06-21
NO865204L (no) 1987-06-22
PT83974B (pt) 1989-05-12
CA1277326C (en) 1990-12-04
FI865108A0 (fi) 1986-12-15
FI865108A (fi) 1987-06-21
AU6681386A (en) 1987-06-25
EP0226223A2 (en) 1987-06-24
AU605123B2 (en) 1991-01-10
DK604886D0 (da) 1986-12-16
NO865204D0 (no) 1986-12-19
US4689182A (en) 1987-08-25
PH23355A (en) 1989-07-14
EP0226223A3 (en) 1990-01-03
JPS62155246A (ja) 1987-07-10
PT83974A (en) 1987-01-01
NZ218588A (en) 1990-03-27
KR900006749B1 (ko) 1990-09-20
CN86108626A (zh) 1987-07-22
ZA869014B (en) 1988-07-27

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