KR900004658A - 이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제 - Google Patents

이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제 Download PDF

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KR900004658A
KR900004658A KR1019890012442A KR890012442A KR900004658A KR 900004658 A KR900004658 A KR 900004658A KR 1019890012442 A KR1019890012442 A KR 1019890012442A KR 890012442 A KR890012442 A KR 890012442A KR 900004658 A KR900004658 A KR 900004658A
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lower alkyl
hydrogen
substituted
wasteyl
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질베르 오바르
알렝 깔베
끌로드 술라드
끌로드 구레
아네 그루엘
앙리 자꼬벨리
쟝-루이 쥐니엥
쟈비에 빠스꼬
프랑스와 로망
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아리엘 엘리아
주베이날 에스.에이.
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Abstract

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Description

이치환 벤질아민, 그의 제조방법, 약제로서 그의 용도 및 그의 합성 약제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 식(I)의 이치환 벤질아민류, 이들의 산부가염 미광학 활성 이성질체(이성질체
    상기식에서, R1은 할로겐 원자, 저급 알킬, 저급 할로알킬 또는 저급 알콕시기에 의해 임의로 일치환 또는 이치환된 폐닐기이고, R2는 저급 알킬기이며, R3및 R4는 서로 동일하거나 또는 상이한 것으로서, 수소, 저급알킬 또는 저급 알케닐기이고, R5는 할로겐 원자, 저급 알콕시기에 의해 임의로 일치환, 이치환 또는 삼치환된 폐닐기이다.
  2. 제1항에 있어서, R1이 폐닐인 벤질 아민.
  3. 제1항에 있어서, R5가 폐닐인 벤질 아민.
  4. 제1항에 있어서, R2가 에틸인 벤질 아민.
  5. 제1항에 있어서, R3이 수소 또는 메틸기이고, R4가 수소 또는 메틸기인벤질아민.
  6. 제1항에 있어서, R1및 R5중 적어도 하나가 치환된 폐닐이고, R3및 R7는 서로 동일하거나 상이한 것으로서, 수소 또는 저급 알킬기이되, R3과 R4가 동시에 수소는 되지 않는 벤질 아민.
  7. 하기 식(I)의 이치환 벤질아민류, 이들의 산부가염 미광학 활성 이성질체와 제약상 허용되는 담체와의 혼합물로 되는 특히 향정신성 질환용 제약 조성물.
    상기식에서, R1은 할로겐 원자, 저급 알킬, 저급 할로알킬 또는 저급 알콕시기에 의해 임의로 일치환 또는 이치환된 폐닐기이고, R2는 저급 알킬기이며, R3및 R4는 서로 동일하거나 또는 상이한 것으로서, 수소, 저급 알킬 또는 저급 알케닐기이고, R5는 할로겐 원자, 저급 알콕시기에 의해 임의로 일치환, 이치환 또는 삼치환된 폐닐기이다.
  8. 하기 식(I)의 이치환 벤질아민류, 이들의 산부가염 미광학 활성 이성질체와 제약상 허용되는 담체와의 혼합물로 되는 특히 향정신성 질환용 제약 조성물.
    상기식에서, R1은 할로겐 원자, 저급 알킬, 저급 할로알킬 또는 저급 알콕시기에 의해 임의로 일치환 또는 이치환된 폐닐기이고, R2는 저급 알킬기이며, R3및 R4는 서로 동일하거나 또는 상이한 것으로서, 수소, 저급 알킬 또는 저급 알케닐기이고, R5는 할로겐 원자, 저급 알콕시기에 의해 임의로 일치환, 이치환 또는 삼치환된 폐닐기이되, R1과 R5중 적어도 하나는 치환된 폐닐이고, R3과R4는 서로 동일하거나 상이한 것으로서 수소 또는 저급 알킬기이되, R3과R4가 동시에 수소는 되지 않는다.
  9. 하기 식 (Ⅱ.1), (Ⅱ.2) 또는 (Ⅱ.3)의 화합물.
    상기 식에서, R1은 할로겐 원자, 저급 알킬, 저급 할로알킬 또는 저급 알콕시기에 의해 임의로 일치환 또는 이치환된 폐닐기이고, R2는 저급 알킬기이며, R3및 R4는 서로 동일하거나 또는 상이한 것으로서, 수소, 저급 알킬 또는 저급 알케닐기이고, R5는 할로겐 원자, 저급 알콕시기에 의해 임의로 일치환, 이치환 또는 삼치환된 폐닐기이되, 화합물(Ⅱ.3)의 경우에 R3과R4는 수소이외의 기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890012442A 1988-09-01 1989-08-30 이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제 KR900004658A (ko)

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FR88-11450 1988-09-01
FR8811450A FR2636625B1 (fr) 1988-09-01 1988-09-01 Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese

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KR1019890012660A KR0152069B1 (ko) 1988-09-01 1989-08-30 알파,알파-이치환 n-시클로알킬 알킬 벤질아민, 이들의 제조방법, 의약품으로서 이들의 용도 및 이들의 합성 중간체
KR1019890012442A KR900004658A (ko) 1988-09-01 1989-08-30 이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제

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AU (1) AU617518B2 (ko)
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JPH06100803B2 (ja) * 1984-06-26 1994-12-12 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料の処理方法
US5849760A (en) * 1993-12-09 1998-12-15 Institut De Recherche Jouveinal 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors
AU760889B2 (en) * 1998-10-14 2003-05-22 Ortho-Mcneil Pharmaceutical, Inc. 1,2-disubstituted cyclopropanes
AU2180400A (en) * 1999-01-13 2000-08-01 Eli Lilly And Company A pharmaceutical combination for the treatment of depression
EP1078630A1 (en) * 1999-08-27 2001-02-28 Warner-Lambert Company Use of sigma receptor agonists for the treatment of depression
EP1138327A1 (en) * 2000-03-29 2001-10-04 Warner-Lambert Company Use of 2-(arylalkenyl)azacycloalkanes derivatives for treating stress-related gastrointestinal disorders
US6436938B1 (en) * 2001-01-22 2002-08-20 Pfizer Inc. Combination treatment for depression
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP7429942B2 (ja) 2015-07-22 2024-02-09 アナベックス ライフ サイエンシズ コーポレイション テトラヒドロ－ｎ，ｎ－ジメチル－２，２－ジフェニル－３－フランメタンアミン（ａｎａｖｅｘ２－７３）のエナンチオマーならびにシグマ１レセプターにより調節されるアルツハイマー型および他の傷害の処置におけるその使用
CN109069414B (zh) 2016-02-11 2022-01-14 西格马瑟拉公司 用于治疗神经退行性疾病的伊格美新
CN107473982B (zh) * 2016-06-08 2020-01-14 四川大学 端位取代高烯丙基胺衍生物及其制备方法和用途

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JPS584748A (ja) * 1981-06-30 1983-01-11 Takasago Corp エナミンまたはイミンの製造方法

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NZ230490A (en) 1991-04-26
JP2525251B2 (ja) 1996-08-14
DK428989D0 (da) 1989-08-30
AU4090089A (en) 1990-05-10
ZA895915B (en) 1991-04-24
FI894134A0 (fi) 1989-09-01
IE62861B1 (en) 1995-03-08
DK428989A (da) 1990-03-02
FI894061A0 (fi) 1989-08-30
IE892795L (en) 1990-03-01
IE63104B1 (en) 1995-03-22
NO171060B (no) 1992-10-12
DK429089A (da) 1990-03-02
NO893481D0 (no) 1989-08-30
IE892794L (en) 1990-03-01
JPH02115148A (ja) 1990-04-27
NO171059B (no) 1992-10-12
US5089639A (en) 1992-02-18
FI96766B (fi) 1996-05-15
AU619888B2 (en) 1992-02-06
FR2636625B1 (fr) 1990-11-09
NZ230210A (en) 1991-05-28
PT91575B (pt) 1995-05-31
EP0361990A1 (fr) 1990-04-04
FI894061A (fi) 1990-03-02
ES2054059T3 (es) 1994-08-01
FR2636625A1 (fr) 1990-03-23
DK173576B1 (da) 2001-03-19
IS3504A7 (is) 1990-03-02
DE68905283T2 (de) 1993-10-14
ATE86602T1 (de) 1993-03-15
FI894134A (fi) 1990-03-02
KR0152069B1 (ko) 1998-10-15
BR1100991A (pt) 1999-10-13
NO171060C (no) 1993-01-20
AU617518B2 (en) 1991-11-28
EP0362001B1 (fr) 1993-03-10
DE68905015D1 (de) 1993-04-01
CA1318682C (en) 1993-06-01
PT91574B (pt) 1995-07-06
DE68905015T2 (de) 1993-09-09
KR900004659A (ko) 1990-04-12
GR3007143T3 (ko) 1993-07-30
PT91575A (pt) 1990-03-30
EP0361990B1 (fr) 1993-02-24
JPH032146A (ja) 1991-01-08
AU4089989A (en) 1990-03-08
ES2054062T3 (es) 1994-08-01
FI96766C (fi) 1996-08-26
NO893481L (no) 1990-03-02
DE68905283D1 (de) 1993-04-15
NO893480D0 (no) 1989-08-30
CA1338940C (en) 1997-02-25
DK429089D0 (da) 1989-08-30
PT91574A (pt) 1990-03-30
GR3007322T3 (ko) 1993-07-30
NO893480L (no) 1990-03-02
ATE85974T1 (de) 1993-03-15
ZA896645B (en) 1991-04-24
IS3498A7 (is) 1990-03-02
EP0362001A1 (fr) 1990-04-04
US5034419A (en) 1991-07-23
NO171059C (no) 1993-01-20

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