KR900004659A - α,α-이치환 N- 시클로알킬알킬 벤질아민, 이들의 제조 방법, 의약품으로서 이들의 용도 및 이들의 합성 중간체 - Google Patents

α,α-이치환 N- 시클로알킬알킬 벤질아민, 이들의 제조 방법, 의약품으로서 이들의 용도 및 이들의 합성 중간체 Download PDF

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KR900004659A
KR900004659A KR1019890012660A KR890012660A KR900004659A KR 900004659 A KR900004659 A KR 900004659A KR 1019890012660 A KR1019890012660 A KR 1019890012660A KR 890012660 A KR890012660 A KR 890012660A KR 900004659 A KR900004659 A KR 900004659A
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cycloalkylalkyl
lower alkyl
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trisubstituted
halogen atom
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질베르 오바르
알렝 깔베
쟝-삐에르 데포
끌로드 구레
아네 그루엘
앙리 자꼬벨리
쟝-루이 쥐니엥
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Abstract

내용 없음

Description

α,α-이치환 N-시클로알킬알킬 벤질아민, 이들의 제조방법, 의약품으로서 이들의 용도 및 이들의 합성 중간체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음 일반식 I의 이치환시킨 N-시클로알킬알킬 벤질아민, 이들의 산부가염 및 이들의 광학 활성형.
    [상기식중, -R1은 할로겐 원자, 저급 할로알킬기 또는 저급 알콕시기에 의해 일-, 이-또는 삼치환된 폐닐이며, -R2는 저급 알킬이며, -R3는 수소 또는 저급 알킬이며, -R4는 시클로알킬-CH(CH2)n(여기서, n은 2 내지 5의 정수임)이고, R4의 탄소원자는 저급 알킬 또는 폐닐인 Rx기를 함유할 수 있어야 하며, -R5는 할로겐 원자, 또는 저급 알콕시기에 의해 일-, 이- 또는 삼치환된 폐닐이며, m은 1 또는 2임].
  2. 제1항에 있어서, R1이 폐닐인 N-시클로알킬알킬 벤질아민.
  3. 제1항에 있어서, R5가 폐닐인 N-시클로알킬알킬 벤질아민.
  4. 제1항에 있어서, R2가 페닐인 N-시클로알킬알킬 벤질아민.
  5. 제1항에 있어서, R3이 수소 또는 메틸인 N-시클로알킬알킬 벤질아민.
  6. 제1항에 있어서, Rx가 메틸 또는 폐닐기 N-시클로알킬알킬 벤질아민.
  7. 다음 일반식 I의 이치환시킨 N-시클로알킬알킬 벤질아민, 이들의 산부가염 및 이들의 광학 활성형 및 제약상 허용 가능한 담체와의 혼합물로 되는 정신병 치료용 약물 제조방법.
    [상기식중, -R1은 할로겐 원자, 저급 할로알킬기 또는 저급 알콕시기에 의해 일-, 이-또는 삼치환된 폐닐이며, -R2는 저급 알킬이며, -R3는 수소 또는 저급 알킬이며, -R4는 시클로알킬-CH(CH2)n(여기서, n은 2 내지 5의 정수임)이고, R4의 탄소원자는 저급 알킬 또는 폐닐인 Rx기를 함유할 수 있어야 하며, -R5는 할로겐 원자, 또는 저급 알콕시기에 의해 일-, 이- 또는 삼치환된 폐닐이며, m은 1 또는 2임].
  8. 다음 일반식 I의 N-시클로알킬알킬 벤질아민, 이들의 산부가염 및 이들의 광학 활성형 및 제약상 허용가능한 담체와의 혼합물로 되는 위장질환 치료용 약물의 제조방법.
    [상기식중, -R1은 할로겐 원자, 저급 할로알킬기 또는 저급 알콕시기에 의해 일-, 이-또는 삼치환된 폐닐이며, -R2는 저급 알킬이며, -R3는 수소 또는 저급 알킬이며, -R4는 시클로알킬-CH(CH2)n(여기서, n은 2 내지 5의 정수임)이고, R4의 탄소원자는 저급 알킬 또는 폐닐인 Rx기를 함유할 수 있어야 하며, -R5는 할로겐 원자, 또는 저급 알콕시기에 의해 일-, 이- 또는 삼치환된 폐닐이며, m은 1 또는 2임].
  9. 다음 일반식 Ⅳ,Ⅷ 및 Ⅸ의 중간체 화합물, 이들의 광학 활성형.
    [상기식중, -R1은 할로겐 원자, 저급 할로알킬기 또는 저급 알콕시기에 의해 일-, 이-또는 삼치환된 폐닐이며, -R2는 저급 알킬이며, -R3는 저급알킬이며 -R4는 시클로알킬-CH(CH2)n(여기서, n은 2 내지 5의 정수임)이고, R4의 탄소원자는 저급 알킬 또는 폐닐인 Rx기를 함유할 수 있어야 하며, -R5는 할로겐 원자, 또는 저급 알콕시기에 의해 일-, 이- 또는 삼치환된 페닐이며, m은 1 또는 2임].
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890012660A 1988-09-01 1989-08-30 알파,알파-이치환 n-시클로알킬 알킬 벤질아민, 이들의 제조방법, 의약품으로서 이들의 용도 및 이들의 합성 중간체 KR0152069B1 (ko)

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FR88-11450 1988-09-01
FR8811450A FR2636625B1 (fr) 1988-09-01 1988-09-01 Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese
FR8811450 1988-09-01

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KR0152069B1 KR0152069B1 (ko) 1998-10-15

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KR1019890012442A KR900004658A (ko) 1988-09-01 1989-08-30 이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제

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JPH06100803B2 (ja) * 1984-06-26 1994-12-12 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料の処理方法
FR2713639B1 (fr) * 1993-12-09 1996-08-30 Irj Nouveaux dérivés de 2-arylalkényl-azacycloalkanes ligands aux récepteurs sigma, leur procédé de préparation et leur application en thérapeutique.
JP2002527414A (ja) 1998-10-14 2002-08-27 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド １，２−ジ置換シクロプロパン
AU2180400A (en) * 1999-01-13 2000-08-01 Eli Lilly And Company A pharmaceutical combination for the treatment of depression
EP1078630A1 (en) * 1999-08-27 2001-02-28 Warner-Lambert Company Use of sigma receptor agonists for the treatment of depression
EP1138327A1 (en) * 2000-03-29 2001-10-04 Warner-Lambert Company Use of 2-(arylalkenyl)azacycloalkanes derivatives for treating stress-related gastrointestinal disorders
US6436938B1 (en) * 2001-01-22 2002-08-20 Pfizer Inc. Combination treatment for depression
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8461389B2 (en) 2008-04-18 2013-06-11 University College Dublin, National University Of Ireland, Dublin Psycho-pharmaceuticals
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP3324956A4 (en) 2015-07-22 2019-02-20 Anavex Life Sciences Corp. ENANTIOMERS OF TETRAHYDRO-N, N-DIMETHYL-2,2-DIPHENYL-3-FURANMETHANAMINE (ANAVEX2-73) AND USE THEREOF IN THE TREATMENT OF MORBUS ALZHEIMER AND OTHER FAILURES MODULATED BY THE SIGMA-1 RECEPTOR
RS62615B1 (sr) 2016-02-11 2021-12-31 Sigmathera Sas Igmezin za upotrebu u lečenju alchajmerove bolesti
CN107473982B (zh) * 2016-06-08 2020-01-14 四川大学 端位取代高烯丙基胺衍生物及其制备方法和用途

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AU4090089A (en) 1990-05-10
NO893480L (no) 1990-03-02
DK429089A (da) 1990-03-02
CA1318682C (en) 1993-06-01
DE68905015T2 (de) 1993-09-09
FI894061A (fi) 1990-03-02
DK429089D0 (da) 1989-08-30
NO893481L (no) 1990-03-02
NO171059B (no) 1992-10-12
IE62861B1 (en) 1995-03-08
AU4089989A (en) 1990-03-08
PT91574B (pt) 1995-07-06
KR900004658A (ko) 1990-04-12
KR0152069B1 (ko) 1998-10-15
PT91575A (pt) 1990-03-30
ATE86602T1 (de) 1993-03-15
FI894134A (fi) 1990-03-02
FI894061A0 (fi) 1989-08-30
ZA895915B (en) 1991-04-24
FI894134A0 (fi) 1989-09-01
ZA896645B (en) 1991-04-24
ES2054062T3 (es) 1994-08-01
EP0362001A1 (fr) 1990-04-04
IS3498A7 (is) 1990-03-02
US5034419A (en) 1991-07-23
NO171060C (no) 1993-01-20
AU617518B2 (en) 1991-11-28
NO171060B (no) 1992-10-12
DE68905283D1 (de) 1993-04-15
GR3007322T3 (ko) 1993-07-30
CA1338940C (en) 1997-02-25
FR2636625B1 (fr) 1990-11-09
NO893481D0 (no) 1989-08-30
EP0361990B1 (fr) 1993-02-24
JPH02115148A (ja) 1990-04-27
IS3504A7 (is) 1990-03-02
IE892794L (en) 1990-03-01
NO171059C (no) 1993-01-20
AU619888B2 (en) 1992-02-06
NZ230210A (en) 1991-05-28
EP0361990A1 (fr) 1990-04-04
FI96766C (fi) 1996-08-26
BR1100991A (pt) 1999-10-13
JPH032146A (ja) 1991-01-08
ATE85974T1 (de) 1993-03-15
EP0362001B1 (fr) 1993-03-10
FR2636625A1 (fr) 1990-03-23
IE63104B1 (en) 1995-03-22
PT91574A (pt) 1990-03-30
PT91575B (pt) 1995-05-31
ES2054059T3 (es) 1994-08-01
GR3007143T3 (ko) 1993-07-30
DE68905015D1 (de) 1993-04-01
US5089639A (en) 1992-02-18
DK173576B1 (da) 2001-03-19
NZ230490A (en) 1991-04-26
IE892795L (en) 1990-03-01
JP2525251B2 (ja) 1996-08-14
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