IT1244698B - Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale - Google Patents

Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale

Info

Publication number
IT1244698B
IT1244698B ITMI910254A ITMI910254A IT1244698B IT 1244698 B IT1244698 B IT 1244698B IT MI910254 A ITMI910254 A IT MI910254A IT MI910254 A ITMI910254 A IT MI910254A IT 1244698 B IT1244698 B IT 1244698B
Authority
IT
Italy
Prior art keywords
general
osteo
preparation
alchyl
arylalkyl
Prior art date
Application number
ITMI910254A
Other languages
English (en)
Inventor
Sergio Rosini
Maurizio Mian
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of ITMI910254A0 publication Critical patent/ITMI910254A0/it
Priority to ITMI910254A priority Critical patent/IT1244698B/it
Priority to PCT/EP1992/000102 priority patent/WO1992013864A1/en
Priority to HU9302188A priority patent/HU215918B/hu
Priority to DK92903398.3T priority patent/DK0569411T3/da
Priority to AT92903398T priority patent/ATE120464T1/de
Priority to HU9801273A priority patent/HU217588B/hu
Priority to KR1019930702242A priority patent/KR100190911B1/ko
Priority to RU9293052408A priority patent/RU2079505C1/ru
Priority to ES92903398T priority patent/ES2069990T3/es
Priority to CA002101548A priority patent/CA2101548C/en
Priority to JP4503474A priority patent/JP3046624B2/ja
Priority to CZ19931533A priority patent/CZ288731B6/cs
Priority to EP92903398A priority patent/EP0569411B1/en
Priority to DE69201863T priority patent/DE69201863T2/de
Priority to SK799-93A priority patent/SK280053B6/sk
Priority to AU11709/92A priority patent/AU653780B2/en
Priority to US08/094,160 priority patent/US5466682A/en
Priority to PT100075A priority patent/PT100075B/pt
Priority to MX9200452A priority patent/MX9200452A/es
Publication of ITMI910254A1 publication Critical patent/ITMI910254A1/it
Priority to FI933231A priority patent/FI105403B/fi
Application granted granted Critical
Publication of IT1244698B publication Critical patent/IT1244698B/it
Priority to HU95P/P00154P priority patent/HU211203A9/hu
Priority to HK98105383.7A priority patent/HK1006311B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Si descrivono acidi idrossidifosfonici di formula generale (I) (FORMULA I) procedimento per la loro preparazione ed il loro impiego in terapia osteo-articolare e dei tessuti connettivi in generale.
ITMI910254A 1991-02-01 1991-02-01 Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale IT1244698B (it)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ITMI910254A IT1244698B (it) 1991-02-01 1991-02-01 Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
JP4503474A JP3046624B2 (ja) 1991-02-01 1992-01-20 骨関節症の治療に用いるアシルアルミノ−アルキリデン−ヒドロキシ−ビスホスホン酸
EP92903398A EP0569411B1 (en) 1991-02-01 1992-01-20 Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases
DK92903398.3T DK0569411T3 (da) 1991-02-01 1992-01-20 Acylaminoalkylidenhydroxybiphosphonsyrer anvendelige til behandling af osteoartikulære sygdomme
AT92903398T ATE120464T1 (de) 1991-02-01 1992-01-20 Acylaminoalkylidenhydroxybisphosphonsäure brauchbar in der therapie von osteoartikularen krankheiten.
HU9801273A HU217588B (hu) 1991-02-01 1992-01-20 Acil-amino-alkilidén-hidroxi-bifoszfonsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
KR1019930702242A KR100190911B1 (ko) 1991-02-01 1992-01-20 골관절질환의치료에유용한아실아미노-알킬리덴-히드록시-비스포스폰산
RU9293052408A RU2079505C1 (ru) 1991-02-01 1992-01-20 N-ациламино-1-гидроксиалкилиден-1,1-бисфосфоновые кислоты и способ их получения
ES92903398T ES2069990T3 (es) 1991-02-01 1992-01-20 Acido acilaminoalquilidenhidroxibisfosfonico util en la terapia de enfermedades osteoarticulares.
CA002101548A CA2101548C (en) 1991-02-01 1992-01-20 Acylamino-alkylidenhydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases
PCT/EP1992/000102 WO1992013864A1 (en) 1991-02-01 1992-01-20 Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases
CZ19931533A CZ288731B6 (cs) 1991-02-01 1992-01-20 Acylaminoalkylidenhydroxybisfosfonové kyseliny a farmaceutické prostředky s jejich obsahem
HU9302188A HU215918B (hu) 1991-02-01 1992-01-20 Eljárás acil-amino-alkilidén-hidroxi-bifoszfonsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására
DE69201863T DE69201863T2 (de) 1991-02-01 1992-01-20 Acylaminoalkylidenhydroxybisphosphonsäure brauchbar in der Therapie von osteoartikularen Krankheiten.
SK799-93A SK280053B6 (sk) 1991-02-01 1992-01-20 Acylamino-alkylidén-hydroxybisfosfónové kyseliny,
AU11709/92A AU653780B2 (en) 1991-02-01 1992-01-20 Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases
US08/094,160 US5466682A (en) 1991-02-01 1992-01-20 Acylamino-alkyliden-hydroxy-bisphosphonic acids esters and salts thereof, wherein the acyl group is derived from an acid having antiinflammatory activity
PT100075A PT100075B (pt) 1991-02-01 1992-01-30 Acidos aril- ou arilalquil-acil-amino-alquil-hidroxidifosfonicos, um processo para a sua preparacao e sua utilizacao na terapia de perturbacoes do tecido osteoarticular e conjuntivo
MX9200452A MX9200452A (es) 1991-02-01 1992-01-31 Acidos aril o arilalquil-acil-amino-alquil-hidroxidifosfonicos, un procedimiento para su preparacion y su uso en la terapia de trastornos ostearticulares y del tejido conectivo.
FI933231A FI105403B (fi) 1991-02-01 1993-07-16 Analogiamenetelmä lääkeaineina käyttökelpoisten asyyliamino-alkylideeni-hydroksi-bisfosfonihappojen valmistamiseksi
HU95P/P00154P HU211203A9 (en) 1991-02-01 1995-06-02 Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases
HK98105383.7A HK1006311B (en) 1991-02-01 1998-06-16 Acylamino-alkyliden-hydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910254A IT1244698B (it) 1991-02-01 1991-02-01 Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale

Publications (3)

Publication Number Publication Date
ITMI910254A0 ITMI910254A0 (it) 1991-02-01
ITMI910254A1 ITMI910254A1 (it) 1992-08-01
IT1244698B true IT1244698B (it) 1994-08-08

Family

ID=11358376

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI910254A IT1244698B (it) 1991-02-01 1991-02-01 Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale

Country Status (19)

Country Link
US (1) US5466682A (it)
EP (1) EP0569411B1 (it)
JP (1) JP3046624B2 (it)
KR (1) KR100190911B1 (it)
AT (1) ATE120464T1 (it)
AU (1) AU653780B2 (it)
CA (1) CA2101548C (it)
CZ (1) CZ288731B6 (it)
DE (1) DE69201863T2 (it)
DK (1) DK0569411T3 (it)
ES (1) ES2069990T3 (it)
FI (1) FI105403B (it)
HU (2) HU215918B (it)
IT (1) IT1244698B (it)
MX (1) MX9200452A (it)
PT (1) PT100075B (it)
RU (1) RU2079505C1 (it)
SK (1) SK280053B6 (it)
WO (1) WO1992013864A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994020508A1 (en) * 1993-03-08 1994-09-15 Eisai Co., Ltd. Phosphonic acid derivatives
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
WO1998039342A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
GB9710521D0 (en) * 1997-05-22 1997-07-16 Boots Co Plc Process
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530139C3 (de) * 1975-04-30 1979-06-21 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen N-Acyl-1 -aminoalkan-1,1 -diphosphonsäuren, deren Herstellung und Verwendung
DE2651904C2 (de) * 1976-11-13 1983-01-05 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von N-Acyl-N-alkylaminomethandiphosphonsäuren
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
EP0084822B1 (de) * 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JPH0778024B2 (ja) * 1988-10-14 1995-08-23 藤沢薬品工業株式会社 医薬化合物とジホスホン酸誘導体の結合体を含有する医薬用製剤
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent

Also Published As

Publication number Publication date
DK0569411T3 (da) 1995-08-28
CZ153393A3 (en) 1994-01-19
DE69201863T2 (de) 1995-09-07
KR100190911B1 (ko) 1999-06-01
SK280053B6 (sk) 1999-07-12
ITMI910254A0 (it) 1991-02-01
ES2069990T3 (es) 1995-05-16
HU211203A9 (en) 1995-11-28
EP0569411A1 (en) 1993-11-18
FI933231L (fi) 1993-07-16
RU2079505C1 (ru) 1997-05-20
PT100075A (pt) 1993-03-31
AU1170992A (en) 1992-09-07
SK79993A3 (en) 1993-12-08
CA2101548C (en) 2002-08-27
HK1006311A1 (en) 1999-02-19
FI933231A0 (fi) 1993-07-16
HU9302188D0 (en) 1993-10-28
ATE120464T1 (de) 1995-04-15
US5466682A (en) 1995-11-14
FI105403B (fi) 2000-08-15
EP0569411B1 (en) 1995-03-29
JP3046624B2 (ja) 2000-05-29
ITMI910254A1 (it) 1992-08-01
MX9200452A (es) 1992-08-01
HUT64964A (en) 1994-03-28
DE69201863D1 (de) 1995-05-04
PT100075B (pt) 1999-06-30
HU215918B (hu) 1999-03-29
JPH06504783A (ja) 1994-06-02
CZ288731B6 (cs) 2001-08-15
AU653780B2 (en) 1994-10-13
CA2101548A1 (en) 1992-08-02
WO1992013864A1 (en) 1992-08-20

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Effective date: 19970226