ES2065242B1 - Derivados del acido fenilacetico, procedimiento para su obtencion y utilizacion correspondiente. - Google Patents

Derivados del acido fenilacetico, procedimiento para su obtencion y utilizacion correspondiente.

Info

Publication number
ES2065242B1
ES2065242B1 ES09202523A ES9202523A ES2065242B1 ES 2065242 B1 ES2065242 B1 ES 2065242B1 ES 09202523 A ES09202523 A ES 09202523A ES 9202523 A ES9202523 A ES 9202523A ES 2065242 B1 ES2065242 B1 ES 2065242B1
Authority
ES
Spain
Prior art keywords
derivatives
procedure
rbs3
rbs2
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09202523A
Other languages
English (en)
Other versions
ES2065242A1 (es
Inventor
Surroca Juan Jose Artus
Jane Llorenc Rafecas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LEPORI FARMA SA
Original Assignee
LEPORI FARMA SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEPORI FARMA SA filed Critical LEPORI FARMA SA
Priority to ES09202523A priority Critical patent/ES2065242B1/es
Priority to AU52177/93A priority patent/AU670139B2/en
Priority to GR930100500A priority patent/GR1002048B/el
Priority to NZ250409A priority patent/NZ250409A/en
Priority to PL93301415A priority patent/PL175116B1/pl
Priority to CA002111169A priority patent/CA2111169C/en
Priority to PL93322378A priority patent/PL174822B1/pl
Priority to HU9303551A priority patent/HUT65711A/hu
Priority to HU9700716A priority patent/HU9700716D0/hu
Priority to KR1019930027558A priority patent/KR100196240B1/ko
Publication of ES2065242A1 publication Critical patent/ES2065242A1/es
Application granted granted Critical
Publication of ES2065242B1 publication Critical patent/ES2065242B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/02—Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains

Abstract

DERIVADOS DEL ACIDO FENILACETICO, PROCEDIMIENTO PARA SU OBTENCION Y UTILIZACION CORRESPONDIENTE; ESTOS DERIVADOS SE IDENTIFICAN POR SU FORMULA III, DONDE RBS1 SC, RBS2 SC Y RBS3 SC, SON RADICALES METILO, ETILO O PROPILO, INDISTINTAMENTE; O RBS2 SC Y RBS3 SC, UNIDOS EN LA FORMA REPRESENTADA POR -(RBS2 SC....RBS3 SC)-, CONSTITUYEN UN RADICAL -(CHSI2 SC)SIN SC- CON N = 4 O 5; EL PROCEDIMIENTO COMPRENDE LA REACCION DE UNA SAL DEL DICLOFENAC, CON UN HALOACETATO DE ALQUILO DE FORMULA X-CHSI2 SC-COO-CRBS1 SCRBS2 SCRBS3 SC, (X = CL O BR) EN UN MEDIO HOMOGENEO. SE UTILIZAN PARA LA PREPARACION DEL ACIDO 2-[(2,6-DICLOROFENIL)AMINO]FENILACETOXIACETICO, POR TRATAMIENTO CON ACIDOS EN MEDIO ANHIDRO. LOS DERIVADOS TIENEN ACTIVIDAD TERAPEUTICA COMO ANALGESICOS O ANTIINFLAMATORIOS.
ES09202523A 1992-12-14 1992-12-14 Derivados del acido fenilacetico, procedimiento para su obtencion y utilizacion correspondiente. Expired - Fee Related ES2065242B1 (es)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ES09202523A ES2065242B1 (es) 1992-12-14 1992-12-14 Derivados del acido fenilacetico, procedimiento para su obtencion y utilizacion correspondiente.
AU52177/93A AU670139B2 (en) 1992-12-14 1993-12-06 Phenylacetic acid derivatives, process for the preparation thereof and corresponding use
GR930100500A GR1002048B (en) 1992-12-14 1993-12-08 Phenilacetic acid derivatives, process for the preparation thereof and corresponding use.
PL93301415A PL175116B1 (pl) 1992-12-14 1993-12-10 Sposób wytwarzania pochodnych kwasu fenylooctowego
CA002111169A CA2111169C (en) 1992-12-14 1993-12-10 Phenylacetic acid derivatives, process for the preparation thereof and corresponding use
PL93322378A PL174822B1 (pl) 1992-12-14 1993-12-10 Sposób wytwarzania kwasu [2-(2,6-dichloroanilino)fenylo] acetoksyoctowego
NZ250409A NZ250409A (en) 1992-12-14 1993-12-10 [2-(2,6-dichlorophenylamino)phenyl]acetoxy acetic acid ester derivatives and pharmaceutical compositions
HU9303551A HUT65711A (en) 1992-12-14 1993-12-13 Process for producing phenylacetic acid derivatives
HU9700716A HU9700716D0 (en) 1992-12-14 1993-12-13 Process for producing[2-(2,6-dichloro-anilino)-phenyl]-acetic-acid
KR1019930027558A KR100196240B1 (ko) 1992-12-14 1993-12-14 페닐아세트산 유도체를 이용한[2-(2,6-(디클로로아닐리노)페닐]아세톡시아세트산의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09202523A ES2065242B1 (es) 1992-12-14 1992-12-14 Derivados del acido fenilacetico, procedimiento para su obtencion y utilizacion correspondiente.

Publications (2)

Publication Number Publication Date
ES2065242A1 ES2065242A1 (es) 1995-02-01
ES2065242B1 true ES2065242B1 (es) 1995-10-01

Family

ID=8279093

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09202523A Expired - Fee Related ES2065242B1 (es) 1992-12-14 1992-12-14 Derivados del acido fenilacetico, procedimiento para su obtencion y utilizacion correspondiente.

Country Status (8)

Country Link
KR (1) KR100196240B1 (es)
AU (1) AU670139B2 (es)
CA (1) CA2111169C (es)
ES (1) ES2065242B1 (es)
GR (1) GR1002048B (es)
HU (1) HUT65711A (es)
NZ (1) NZ250409A (es)
PL (2) PL174822B1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE255086T1 (de) * 1998-04-28 2003-12-15 Russinsky Ltd Verfahren zur herstellung von aceclofenac
AU4170099A (en) * 1998-06-03 1999-12-20 Jae Chul Kim Haloethyl-2-[ (2,6-dichlorophenyl) amino] phenylacetoxyacetate derivatives and their use as an intermediate to synthesize aceclofenac
WO2005073163A1 (en) * 2004-01-30 2005-08-11 J.B.Chemicals & Pharmaceuticals Ltd. A process for the preparation of [2-(2,6-dichloro anilino) phenyl] acetoxy acetic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3811120A1 (de) * 1988-03-31 1989-10-12 Merckle Gmbh Neopentylesterderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ES2020146A6 (es) * 1990-05-29 1991-07-16 Prodesfarma Sa Procedimiento de obtencion del acido 2-(2, 6-diclorofenil)amino) fenilacetoxiacetico.
ES2020145A6 (es) * 1990-05-29 1991-07-16 Prodesfarma Sa Procedimiento de obtencion de esteres del acido 2-(2,6-diclorofenil)amino) fenilacetoxiacetico.

Also Published As

Publication number Publication date
KR940014301A (ko) 1994-07-18
KR100196240B1 (ko) 1999-06-15
AU670139B2 (en) 1996-07-04
CA2111169C (en) 2001-05-01
PL175116B1 (pl) 1998-11-30
CA2111169A1 (en) 1994-06-15
HUT65711A (en) 1994-07-28
PL301415A1 (en) 1994-06-27
HU9303551D0 (en) 1994-04-28
AU5217793A (en) 1994-06-23
GR1002048B (en) 1995-11-16
NZ250409A (en) 1995-07-26
ES2065242A1 (es) 1995-02-01
GR930100500A (el) 1994-08-31
PL174822B1 (pl) 1998-09-30

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Legal Events

Date Code Title Description
PC2A Transfer of patent
FD2A Announcement of lapse in spain

Effective date: 20180806