KR880005927A - 카복실산 아미드의 용도 - Google Patents

카복실산 아미드의 용도 Download PDF

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Publication number
KR880005927A
KR880005927A KR1019870012470A KR870012470A KR880005927A KR 880005927 A KR880005927 A KR 880005927A KR 1019870012470 A KR1019870012470 A KR 1019870012470A KR 870012470 A KR870012470 A KR 870012470A KR 880005927 A KR880005927 A KR 880005927A
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KR
South Korea
Prior art keywords
formula
compound
alkyl
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
KR1019870012470A
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English (en)
Inventor
클라우스 미카엘
Original Assignee
쟝-쟈크 오가이, 프리돌린 클라우스너
에프.호프만-라 롯슈 앤드 캄파니 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 쟝-쟈크 오가이, 프리돌린 클라우스너, 에프.호프만-라 롯슈 앤드 캄파니 아크티엔게젤샤프트 filed Critical 쟝-쟈크 오가이, 프리돌린 클라우스너
Publication of KR880005927A publication Critical patent/KR880005927A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

카복실산 아미드의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 염증 및 류마티스성 질환 치료용 약제의 제조에 사용되는 하기 일반식(I)의 화합물 및 일반식(I)의 카복실산의 약제학적으로 허용되는 염.
    상기 식에서, R1,R2,R3,R4및 R5는 각기 독립적으로 수소, 알킬, 바람직하게는 저급 알킬, 또는 C1-7-사이클로알킬을 나타내거나, R1내지 R5중 두개의 인접한 잔기가 임의로 저급-알킬-치환된 5 내지 7원환을 나타내며 X는 잔기 -NR7-CO- 또는 -CO-NR7-을 나타내고 ; R6은 하이드록시, 저급-알콕시 또는 -NR8R9를 나타내며 ; R7,R8및 R9는 수소 또는 저급-알킬을 나타낸다.
  2. 제1항에 있어서, R2및 R3는 함께 저급-알킬로 치환된 환을 나타내고, X는 -CO-NH-또는-NH-CO-를 나타내는 일반식(I)의 화합물.
  3. 제1항에 있어서, 하기 일반식(Ia)화합물 및 그의 약제학적으로 허용되는 염.
    상기 식에서, X는 -CO-NH-또는 -NH-CO-를 나타낸다.
  4. 염증 및 류마티스성 질환의 치료를 위한 제1항의 일반식(I)의 화합물 및 일반식(I)의 카복실산의 약제학적으로 허용되는 염.
  5. 제4항에 있어서, R2및 R3는 함께 저급-알킬로 치환된 환을 나타내고 X는 CO-NH-또는 NH-CO-를 나타내는 화합물.
  6. 제4항에 있어서, 하기 일반식(Ia)화합물 및 그의 약제학적으로 허용되는 염.
    상기 식에서, X는 -CO-NH-또는-NH-CO를 나타낸다.
  7. 치료를 필요로 하는 온혈동물에 유효향의 제1항의 일반식(I) 화합물 또는 일반식(I)의 카복실산의 약제학적으로 허용되는 염을 투여함을 특징으로 하여 염증 및 류마티스성 질환을 치료하는 방법.
  8. 제7항에 있어서, R2및 R3가 함께 저급-알킬로 치환된 환을 나타내고 X는 -CO-NH-또는 NH-CO-를 나타내는 방법.
  9. 제7항에 있어서, 일반식(I)의 화합물이 하기 일반식(Ia)의 화합물인 방법.
    상기 식에서, X는 -CO-NH-또는-NH-CO- 를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870012470A 1986-11-07 1987-11-06 카복실산 아미드의 용도 KR880005927A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH443886 1986-11-07
CH4438/86 1986-11-07

Publications (1)

Publication Number Publication Date
KR880005927A true KR880005927A (ko) 1988-07-21

Family

ID=4276129

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870012470A KR880005927A (ko) 1986-11-07 1987-11-06 카복실산 아미드의 용도

Country Status (13)

Country Link
US (1) US4808631A (ko)
EP (1) EP0269899B1 (ko)
JP (1) JPS63130569A (ko)
KR (1) KR880005927A (ko)
AT (1) ATE86486T1 (ko)
AU (1) AU609428B2 (ko)
CA (1) CA1297033C (ko)
DE (1) DE3784642D1 (ko)
HU (1) HU198388B (ko)
IE (1) IE62333B1 (ko)
IL (1) IL84321A (ko)
PH (1) PH24295A (ko)
ZA (1) ZA878175B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2752630B2 (ja) * 1988-03-29 1998-05-18 大鵬薬品工業株式会社 新規安息香酸誘導体及びその製造方法
USRE36477E (en) * 1988-03-29 1999-12-28 Taiho Pharmaceutical Co., Ltd. Benzoic acid derivatives and process for preparing the same
CA2020887A1 (en) * 1989-07-28 1991-01-29 Michael Klaus Aromatic carboxylic amides
WO1991014673A1 (en) * 1990-03-20 1991-10-03 Shionogi & Co., Ltd. Novel process for producing benzoic acid derivative
US5466861A (en) * 1992-11-25 1995-11-14 Sri International Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
DE4436127A1 (de) * 1994-09-27 1996-03-28 Deutsches Rheumaforschungszent Verwendung von aromatischen Amiden und Säuren zur Behandlung von rheumatischen Erkrankungen
US6008251A (en) * 1998-03-27 1999-12-28 Bristol-Myers Squibb Company Retinoid-like compounds
US20050202055A1 (en) * 2004-03-11 2005-09-15 Koichi Shudo, Tokyo, Japan Anti-wrinkle agent
NZ580209A (en) 2007-03-30 2011-11-25 Tmrc Co Ltd Tamibarotene capsule preparation
EP2181710A1 (en) * 2008-10-28 2010-05-05 Phenex Pharmaceuticals AG Ligands for modulation of orphan receptor-gamma (NR1F3) activity
GB0915196D0 (en) 2009-09-01 2009-10-07 King S College London Therapeutic compounds and their use
WO2015045037A1 (ja) * 2013-09-25 2015-04-02 テムリック株式会社 カプセル製剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6795374A (en) * 1973-04-20 1975-10-16 Microbial Chem Res Found Inhibitors
JPS5764655A (en) * 1980-10-04 1982-04-19 Nippon Zoki Pharmaceut Co Ltd Novel benzoylaminophenylcarboxylic acid derivative, its preparation, and drug composition comprising it
DE3202100A1 (de) * 1982-01-23 1983-08-04 Basf Ag, 6700 Ludwigshafen Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
JPS60116657A (ja) * 1983-11-30 1985-06-24 Ono Pharmaceut Co Ltd アニリン誘導体
EP0170105B1 (en) * 1984-07-07 1990-10-17 Koichi Prof. Dr. Shudo Benzoic acid derivatives

Also Published As

Publication number Publication date
DE3784642D1 (de) 1993-04-15
IE62333B1 (en) 1995-01-25
JPS63130569A (ja) 1988-06-02
AU609428B2 (en) 1991-05-02
EP0269899A2 (de) 1988-06-08
ZA878175B (en) 1988-05-09
US4808631A (en) 1989-02-28
ATE86486T1 (de) 1993-03-15
HU198388B (en) 1989-10-30
HUT44933A (en) 1988-05-30
AU8088487A (en) 1988-05-12
CA1297033C (en) 1992-03-10
EP0269899B1 (de) 1993-03-10
IL84321A (en) 1993-07-08
EP0269899A3 (en) 1990-05-09
PH24295A (en) 1990-05-29
IE872996L (en) 1988-05-07

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