PT96394A - Processo para a preparacao de novos derivados do acido a-nor-esteroide-3-carboxilico e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados do acido a-nor-esteroide-3-carboxilico e de composicoes farmaceuticas que os contem

Info

Publication number
PT96394A
PT96394A PT96394A PT9639490A PT96394A PT 96394 A PT96394 A PT 96394A PT 96394 A PT96394 A PT 96394A PT 9639490 A PT9639490 A PT 9639490A PT 96394 A PT96394 A PT 96394A
Authority
PT
Portugal
Prior art keywords
steroid
carboxylic acid
pharmaceutical compositions
compositions containing
reductase
Prior art date
Application number
PT96394A
Other languages
English (en)
Other versions
PT96394B (pt
Inventor
Philippe Bey
Thomas Robert Blohm
Gary Alan Flynn
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT96394A publication Critical patent/PT96394A/pt
Publication of PT96394B publication Critical patent/PT96394B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT96394A 1989-12-29 1990-12-28 Processo para a preparacao de novos derivados do acido a-nor-esteroide-3-carboxilico e de composicoes farmaceuticas que os contem PT96394B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45886989A 1989-12-29 1989-12-29
US07/580,759 US5100917A (en) 1989-12-29 1990-09-11 Novel a-nor-steroid-3-carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
PT96394A true PT96394A (pt) 1991-10-15
PT96394B PT96394B (pt) 1998-10-30

Family

ID=27039140

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96394A PT96394B (pt) 1989-12-29 1990-12-28 Processo para a preparacao de novos derivados do acido a-nor-esteroide-3-carboxilico e de composicoes farmaceuticas que os contem

Country Status (20)

Country Link
US (1) US5100917A (pt)
EP (1) EP0435321B1 (pt)
JP (1) JP3039996B2 (pt)
KR (3) KR0178468B1 (pt)
CN (4) CN1033809C (pt)
AT (1) ATE126232T1 (pt)
AU (1) AU634326B2 (pt)
CA (1) CA2033392C (pt)
DE (1) DE69021530T2 (pt)
DK (1) DK0435321T3 (pt)
ES (1) ES2078291T3 (pt)
FI (1) FI94418C (pt)
GR (1) GR3017559T3 (pt)
HU (1) HU210340B (pt)
IE (1) IE67511B1 (pt)
IL (1) IL96790A (pt)
MX (1) MX9203338A (pt)
NO (1) NO180719C (pt)
NZ (1) NZ236589A (pt)
PT (1) PT96394B (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543406A (en) * 1991-12-20 1996-08-06 Glaxo Wellcome, Inc. Inhibitors of 5-α-testosterone reductase
WO1993023053A1 (en) * 1992-05-21 1993-11-25 Endorecherche Inc. INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
GB9224148D0 (en) * 1992-11-18 1993-01-06 Smithkline Beecham Corp Compounds
US5561124A (en) * 1992-11-18 1996-10-01 Webb; Robert L. 17-α-acyl steroids which inhibit 5-α-reductase
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
AU2003279493B2 (en) 2002-10-25 2009-08-20 Foamix Pharmaceuticals Ltd. Cosmetic and pharmaceutical foam
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US9668972B2 (en) * 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8119109B2 (en) * 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7704518B2 (en) * 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
FR2857968B1 (fr) * 2003-07-25 2006-02-03 Inovat Sarl Nouveaux derives steroides et leurs utilisations therapeuthique
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
JP2008540508A (ja) * 2005-05-09 2008-11-20 フォーミックス エルティーディー． 起泡性ビヒクル及びその医薬組成物
US20080152596A1 (en) * 2005-07-19 2008-06-26 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
US20080260655A1 (en) * 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US20080206155A1 (en) * 2006-11-14 2008-08-28 Foamix Ltd. Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2010041141A2 (en) 2008-10-07 2010-04-15 Foamix Ltd. Oil-based foamable carriers and formulations
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
WO2009090558A2 (en) * 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
CN102686205A (zh) 2009-10-02 2012-09-19 弗艾米克斯有限公司 局部四环素组合物
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
JP5527236B2 (ja) * 2011-01-31 2014-06-18 信越化学工業株式会社 ポジ型化学増幅レジスト材料、パターン形成方法及び酸分解性ケトエステル化合物
MX2017011630A (es) 2016-09-08 2018-09-25 Foamix Pharmaceuticals Ltd Composiciones y metodos para tratar rosacea y acne.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3336338A (en) * 1963-09-13 1967-08-15 Squibb & Sons Inc A-nor-cholestatriene-21-oic acid 21->24 lactones
US3600425A (en) * 1963-09-13 1971-08-17 Squibb & Sons Inc Synthesis of steroids
US3484476A (en) * 1963-09-13 1969-12-16 Squibb & Sons Inc A-nor steroids
US3424751A (en) * 1965-10-20 1969-01-28 Du Pont Selected 2-formyl-and 2alpha-(cyanoamidino)-a-nor-5alpha-androstane derivatives
US3492359A (en) * 1966-01-14 1970-01-27 Squibb & Sons Inc 11,12-oxo and/or oxy substituted a-norpregnenes
US4910226A (en) * 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors

Also Published As

Publication number Publication date
JP3039996B2 (ja) 2000-05-08
GR3017559T3 (en) 1995-12-31
NO180719B (no) 1997-02-24
CN1127258A (zh) 1996-07-24
IE904720A1 (en) 1991-07-17
HU210340B (en) 1995-03-28
IL96790A (en) 1995-03-15
FI94418C (fi) 1995-09-11
JPH04134094A (ja) 1992-05-07
EP0435321A3 (en) 1992-04-29
CN1052866A (zh) 1991-07-10
FI906438A0 (fi) 1990-12-28
KR0178471B1 (ko) 1999-04-01
DK0435321T3 (da) 1995-09-18
KR910011887A (ko) 1991-08-07
KR0178470B1 (ko) 1999-04-01
AU634326B2 (en) 1993-02-18
NZ236589A (en) 1993-02-25
ATE126232T1 (de) 1995-08-15
MX9203338A (es) 1992-09-01
DE69021530D1 (de) 1995-09-14
KR0178468B1 (ko) 1999-04-01
NO905608D0 (no) 1990-12-27
AU6844790A (en) 1991-07-04
IE67511B1 (en) 1996-04-03
IL96790A0 (en) 1991-09-16
EP0435321A2 (en) 1991-07-03
NO180719C (no) 1997-06-04
HU908495D0 (en) 1991-07-29
CN1127257A (zh) 1996-07-24
EP0435321B1 (en) 1995-08-09
FI94418B (fi) 1995-05-31
DE69021530T2 (de) 1996-02-01
FI906438A (fi) 1991-06-30
CN1036200C (zh) 1997-10-22
HUT56379A (en) 1991-08-28
CA2033392C (en) 2002-08-27
US5100917A (en) 1992-03-31
CA2033392A1 (en) 1991-06-30
NO905608L (no) 1991-07-01
CN1127256A (zh) 1996-07-24
PT96394B (pt) 1998-10-30
ES2078291T3 (es) 1995-12-16
CN1033809C (zh) 1997-01-15

Similar Documents

Publication Publication Date Title
PT96394A (pt) Processo para a preparacao de novos derivados do acido a-nor-esteroide-3-carboxilico e de composicoes farmaceuticas que os contem
PT99545A (pt) Processo de preparacao de compostos inibidores da protease retroviral dos seus intermediarios e de composicoes farmaceuticas que os contem
PT99267A (pt) Processo para a preparacao de novos derivados de mercaptoacetilamida e de composicoes farmaceuticas que os contem
PT84698B (pt) Processo para a preparacao de derivados de acido acrilico e de composicoes fungicidas que os contem
PT89094A (pt) Processo para a preparacao de 1-aril-3-quinolina-e 1-aril-3-isoquinolina-carboxamidas e de composicoes farmaceuticas que as contem
PT82591B (pt) Processo para a preparacao de derivados do acido ascorbico e de composicoes farmaceuticas que os contem
PT91287A (pt) Processo de preparacao de derivados do acido indazol-3-carboxilico e de composicoes farmaceuticas que os contem
PT82780B (pt) Processo para a preparacao de derivados heterociclicos de acido acrilico com propriedades fungicidas e de composicoes fungicidas que os contem
PT83186B (pt) Processo para a preparacao de uma modificacao estavel de1-isopropil-3-{(4-m-toluidino-3-piridil)-sulfonil}-ureia (torasemida) e de composicoes farmaceuticas que os contem
PT84704B (pt) Processo para a preparacao de derivados do acido tiolactam-n-acetico e de composicoes farmaceuticas que os contem
PT84681B (pt) Processo para a preparacao de carboxamidas heterociclicas e de composicoes farmaceuticas que as contem
PT83397B (pt) Processo para a preparacao de aril-piridinas e de composicoes insecticidas que as contem
PT84364B (pt) Processo para a preparacao de derivados do acido 1h-imidazol-5-carboxilico e de composicoes herbicidas que os contem
PT89311A (pt) Processo para a preparacao de novos aminoalcoxi-p-benzonitrilos substituidos utilizaveis como agentes antiarritmicos e de composicoes farmaceuticas que os contem
PT91870A (pt) Processo para apreparacao de novas quinoliloxazol-2-onas e de composicoes farmaceuticas que as contem
PT88335A (pt) Processo para a preparacao de derivados do acido 1,4-dihidro-4-oxo-3-quinolinocarboxilico e de composicoes farmaceuticas que os contem
PT87952A (pt) Processo para a preparacao de amidas substituidas derivadas de acidos alceno-carboxilicos e de seus derivados e composicoes farmaceuticas que as contem
PT88351A (pt) Processo para a preparacao de derivados de isoxazol-beta-carbolina e de composicoes farmaceuticas que os contem
PT84123B (pt) Processo para a preparacao de derivados substituidos do acido 4-amibo-3-hidroxibutirico e de composicoes farmaceuticas que os contem
PT84794B (pt) Processo de preparacao de derivados de benzimidazois substituido e de composicoes farmaceuticas que os contem
PT82167B (pt) Processo para a preparacao de sulfureto heterociclicos e de composicoes farmceuticas que os contem
PT80876B (pt) Processo para a preparacao de derivados do acido fenil-nonatetraenoico e de composicoes farmaceuticas que os contem
PT89253A (pt) Processo para a preparacao de derivados de 4' e de composicoes farmaceuticas que os contem
PT84565B (pt) Processo para a preparacao de derivados de acido 4-amino-3-hidroxi-butirico substituidos e de composicoes farmaceuticas que os contem
PT88917A (pt) Processo para a preparacao de derivados de piridoxal-hidrazona e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19910531

FG3A Patent granted, date of granting

Effective date: 19980724

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020131

NF3A Restitutio in integrum

Free format text: RESTITUTIO IN INTEGRUMO

Effective date: 20020821

Free format text: 20020821 RESTITUTIO IN INTEGRUM

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040131