CY1955A - Immunomodulatory azaspiranes - Google Patents
Immunomodulatory azaspiranesInfo
- Publication number
- CY1955A CY1955A CY195597A CY195597A CY1955A CY 1955 A CY1955 A CY 1955A CY 195597 A CY195597 A CY 195597A CY 195597 A CY195597 A CY 195597A CY 1955 A CY1955 A CY 1955A
- Authority
- CY
- Cyprus
- Prior art keywords
- azaspiranes
- immunomodulatory
- immunomodulatory azaspiranes
- formulae
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
- C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Ceramic Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10170487A | 1987-09-28 | 1987-09-28 | |
US07/244,229 US4963557A (en) | 1987-09-28 | 1988-09-13 | Immunomodulatory azaspiranes |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1955A true CY1955A (en) | 1997-05-16 |
Family
ID=26798539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY195597A CY1955A (en) | 1987-09-28 | 1997-05-16 | Immunomodulatory azaspiranes |
Country Status (24)
Country | Link |
---|---|
US (1) | US4963557A (xx) |
EP (1) | EP0310321B1 (xx) |
JP (1) | JP2582888B2 (xx) |
KR (1) | KR0166336B1 (xx) |
CN (1) | CN1031618C (xx) |
AT (1) | ATE114463T1 (xx) |
AU (1) | AU619780B2 (xx) |
CA (1) | CA1313189C (xx) |
CY (1) | CY1955A (xx) |
DE (1) | DE3852266T2 (xx) |
DK (1) | DK170042B1 (xx) |
ES (1) | ES2064356T3 (xx) |
FI (1) | FI93006C (xx) |
GR (1) | GR3014931T3 (xx) |
HK (1) | HK1006274A1 (xx) |
HU (1) | HU208809B (xx) |
IE (1) | IE67891B1 (xx) |
IL (1) | IL87908A (xx) |
MX (1) | MX9203765A (xx) |
NO (1) | NO173824C (xx) |
NZ (1) | NZ226354A (xx) |
PT (1) | PT88603B (xx) |
WO (1) | WO1989002889A1 (xx) |
ZW (1) | ZW12388A1 (xx) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051596A (en) * | 1990-08-10 | 2000-04-18 | Anormed, Inc. | Immunosuppressive compositions |
DE69129459T2 (de) * | 1990-08-10 | 1998-10-15 | Anormed Inc | Immunosuppressive zusammensetzungen |
WO1992004899A1 (en) * | 1990-09-24 | 1992-04-02 | Smithkline Beecham Corporation | Methods |
ZA921120B (en) * | 1991-02-19 | 1993-01-27 | Smithkline Beecham Corp | Cytokine inhibitors |
US5591748A (en) * | 1991-06-07 | 1997-01-07 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
PT100566B (pt) * | 1991-06-07 | 1999-06-30 | Smithkline Beecham Corp | Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso |
US5455247A (en) * | 1991-10-25 | 1995-10-03 | Smithkline Beecham Corporation | Methods for the treatment of hyperlipidemia using azaspiranes |
GB9122735D0 (en) * | 1991-10-25 | 1991-12-11 | Smithkline Beecham Corp | Methods |
GB9122721D0 (en) * | 1991-10-25 | 1991-12-11 | Smithkline Beecham Corp | Methods |
US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
US7101534B1 (en) | 1991-12-18 | 2006-09-05 | 3M Innovative Properties Company | Suspension aerosol formulations |
ATE204743T1 (de) * | 1991-12-18 | 2001-09-15 | Minnesota Mining & Mfg | Aerosolzusammensetzungen für arzneimittelsuspensionen |
GB9201804D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Corp | Methods |
GB9201803D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Corp | Methods |
US5482959A (en) * | 1992-01-28 | 1996-01-09 | Smithkline Beecham Corporation | Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds |
DE4222459C2 (de) * | 1992-07-08 | 1995-09-14 | Sigma Tau Ind Farmaceuti | 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
GB9217116D0 (en) * | 1992-08-13 | 1992-09-23 | Smithkline Beecham Corp | Methods |
GB9217121D0 (en) * | 1992-08-13 | 1992-09-23 | Smithkline Beecham Corp | Methods |
ATE241359T1 (de) * | 1993-03-26 | 2003-06-15 | Beth Israel Hospital | Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind |
US5484788A (en) * | 1993-03-26 | 1996-01-16 | Beth Israel Hospital Association | Buspirone as a systemic immunosuppressant |
US5631017A (en) * | 1993-03-26 | 1997-05-20 | Beth Israel Deaconess Medical Center, Inc. | Topical application of buspirone for treatment of pathological conditions associated with immune responses |
GB9308780D0 (en) * | 1993-04-28 | 1993-06-09 | Smithkline Beecham Corp | Methods |
US5708019A (en) * | 1993-04-28 | 1998-01-13 | Smithkline Beecham Corporation | Methods of treating hyperlipidemia using azaspirane derivatives |
US5505948A (en) * | 1993-06-01 | 1996-04-09 | Dermatology Home Products, Inc. | Home skin peel composition for producing healthy and attractive skin |
GB9315341D0 (en) * | 1993-07-23 | 1993-09-08 | Smithkline Beecham Corp | Methods |
GB9315351D0 (en) * | 1993-07-23 | 1993-09-08 | Smithkline Beecham Corp | Methods |
GB9315306D0 (en) * | 1993-07-23 | 1993-09-08 | Smithkline Beecham Corp | Methods |
GB9315340D0 (en) * | 1993-07-23 | 1993-09-08 | Smithkline Beecham Corp | Methods |
GB9315271D0 (en) * | 1993-07-23 | 1993-09-08 | Smithkline Beecham Corp | Methods |
GB9315298D0 (en) * | 1993-07-23 | 1993-09-08 | Smithkline Beecham Corp | Methods |
US5461054A (en) * | 1993-12-09 | 1995-10-24 | Bayer Aktiengesellschaft | Anthracene-spiro-pyrrolindines |
GB9325854D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Corp | Porcess |
GB9414902D0 (en) * | 1994-07-23 | 1994-09-14 | Smithkline Beecham Corp | Methods |
US5786376A (en) * | 1994-07-23 | 1998-07-28 | Smithkline Beecham Corporation | Methods of treating opportunistic infections with azaspiranes |
GB9414901D0 (en) * | 1994-07-23 | 1994-09-14 | Smithkline Beecham Corp | Methods |
US5734061A (en) * | 1994-12-07 | 1998-03-31 | Smithkline Beecham Corporation | Process for preparing spirocyclic lactams |
US5637314A (en) * | 1995-06-07 | 1997-06-10 | Beth Israel Deaconess Medical Center, Inc. | Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis |
BR9601909A (pt) * | 1995-07-13 | 1999-10-13 | Smithkline Beecham Corp | N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato |
US5952365A (en) * | 1995-07-13 | 1999-09-14 | Anormed Inc. | 2- 2-(Dimethylamino)ethyl!-8,8-dipropyl-2-azaspiro 4.5!decane dimaleate |
SK281254B6 (sk) * | 1995-07-13 | 2001-01-18 | Smithkline Beecham Corporation | Použitie@kán-2-propánamínu, farmaceutický prostriedok s jeho obsahom a jeho použitie |
EP0837678A1 (en) * | 1995-07-13 | 1998-04-29 | Smithkline Beecham Corporation | N,n-dimethyl-8,8-dipropyl-2-azaspiro 4,5]decane-2-propanamine dimaleate |
HUP0003908A3 (en) * | 1996-05-17 | 2001-04-28 | Anormed Inc Langley | Use of substituted azaspirane in the manufacture of a medicament for use in treating asthma |
US5843936A (en) * | 1996-06-28 | 1998-12-01 | Bernstein; Lawrence R. | Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
US7582284B2 (en) | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
JP4458514B2 (ja) | 2002-07-18 | 2010-04-28 | 第一三共株式会社 | 高純度のエナミン類の製造方法 |
US20070015780A1 (en) * | 2003-03-10 | 2007-01-18 | Picker Donald H | Method of treating cancer with azaspirane compositions |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
CN101044134A (zh) * | 2004-09-20 | 2007-09-26 | 塔加西普特公司 | 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物 |
BRPI0609515A8 (pt) | 2005-03-23 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Composto, composição farmacêutica, e, uso de um composto |
AR057894A1 (es) | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
ES2335242T3 (es) | 2006-01-24 | 2010-03-23 | Actelion Pharmaceuticals Ltd. | Derivados novedosos de piridina. |
EP1989297B1 (en) | 2006-02-13 | 2015-03-25 | The Board of Trustees of The Leland Stanford Junior University | Blockade of gamma-secretase activity to promote myelination by oligodendrocytes |
WO2008097664A1 (en) | 2007-02-11 | 2008-08-14 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3256277A (en) * | 1966-06-14 | Azaspiro alkanes | ||
GB823338A (en) * | 1956-11-07 | 1959-11-11 | Thomae Gmbh Dr K | Diquaternary salts of aminoalkyl piperidines |
US3106552A (en) * | 1960-07-19 | 1963-10-08 | Geschickter Fund Med Res | Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation |
US3418324A (en) * | 1961-03-13 | 1968-12-24 | Geschickter Fund Med Res | Heterocyclic secondary amines |
US3282947A (en) * | 1962-05-17 | 1966-11-01 | Geschickter Fund Med Res | Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds |
NL124128C (xx) * | 1963-05-27 | |||
US3424755A (en) * | 1964-03-09 | 1969-01-28 | Rolf Denss | 4-piperidine-p-fluorobutyrophenones and related compounds |
US3432499A (en) * | 1965-04-02 | 1969-03-11 | Geschickter Fund Med Res | Trifluoromethylazaspiranes and azaspirane diones |
DE1770697C3 (de) * | 1967-07-06 | 1981-04-23 | Dupher International Research B.V., Weesp | 2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel |
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
BE788490A (fr) * | 1971-09-08 | 1973-01-02 | Geschickter Fund Med Res | Azaspiranes substitues par du silicium ou du germanium, leur preparation et compositions pharmaceutiques les contenant |
US4468393A (en) * | 1982-12-06 | 1984-08-28 | Unimed, Inc. | Treatment of arthritis |
EP0181351A4 (en) * | 1984-05-09 | 1989-06-21 | Univ Australian | METHOD FOR MODULATING IMMUNE REACTION. |
JPH0662407B2 (ja) * | 1984-12-25 | 1994-08-17 | 株式会社三和化学研究所 | 安定化された3―オキシゲルミルプロピオン酸ポリマーを有効成分とする免疫調整剤 |
US4654333A (en) * | 1986-02-18 | 1987-03-31 | Unimed, Inc. | Treatment of multiple sclerosis |
-
1988
- 1988-09-13 US US07/244,229 patent/US4963557A/en not_active Expired - Lifetime
- 1988-09-21 ZW ZW123/88A patent/ZW12388A1/xx unknown
- 1988-09-25 IL IL87908A patent/IL87908A/xx not_active IP Right Cessation
- 1988-09-26 EP EP88308914A patent/EP0310321B1/en not_active Expired - Lifetime
- 1988-09-26 ES ES88308914T patent/ES2064356T3/es not_active Expired - Lifetime
- 1988-09-26 DE DE3852266T patent/DE3852266T2/de not_active Expired - Lifetime
- 1988-09-26 AT AT88308914T patent/ATE114463T1/de not_active IP Right Cessation
- 1988-09-27 WO PCT/US1988/003323 patent/WO1989002889A1/en active IP Right Grant
- 1988-09-27 JP JP63508105A patent/JP2582888B2/ja not_active Expired - Lifetime
- 1988-09-27 HU HU885889A patent/HU208809B/hu not_active IP Right Cessation
- 1988-09-27 KR KR1019890700907A patent/KR0166336B1/ko not_active IP Right Cessation
- 1988-09-27 AU AU25333/88A patent/AU619780B2/en not_active Expired
- 1988-09-27 CA CA000578528A patent/CA1313189C/en not_active Expired - Lifetime
- 1988-09-27 NZ NZ226354A patent/NZ226354A/xx unknown
- 1988-09-27 PT PT88603A patent/PT88603B/pt not_active IP Right Cessation
- 1988-09-28 IE IE292988A patent/IE67891B1/en not_active IP Right Cessation
- 1988-09-28 CN CN88109032A patent/CN1031618C/zh not_active Expired - Lifetime
-
1990
- 1990-03-23 DK DK077090A patent/DK170042B1/da not_active IP Right Cessation
- 1990-03-27 FI FI901530A patent/FI93006C/fi not_active IP Right Cessation
- 1990-03-27 NO NO901392A patent/NO173824C/no not_active IP Right Cessation
-
1992
- 1992-06-29 MX MX9203765A patent/MX9203765A/es unknown
-
1995
- 1995-02-01 GR GR950400195T patent/GR3014931T3/el unknown
-
1997
- 1997-05-16 CY CY195597A patent/CY1955A/xx unknown
-
1998
- 1998-06-16 HK HK98105430A patent/HK1006274A1/xx not_active IP Right Cessation
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