ATE241359T1 - Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind - Google Patents

Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind

Info

Publication number
ATE241359T1
ATE241359T1 AT94911001T AT94911001T ATE241359T1 AT E241359 T1 ATE241359 T1 AT E241359T1 AT 94911001 T AT94911001 T AT 94911001T AT 94911001 T AT94911001 T AT 94911001T AT E241359 T1 ATE241359 T1 AT E241359T1
Authority
AT
Austria
Prior art keywords
topical
treatment
buspiron
derivatives
immune responses
Prior art date
Application number
AT94911001T
Other languages
English (en)
Inventor
Richard J Sharpe
Kenneth A Arndt
Stephen J Galli
Peter C Meltzer
Raj K Razdan
Howard P Sard
Original Assignee
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/037,225 external-priority patent/US5631017A/en
Priority claimed from US08/037,271 external-priority patent/US5484788A/en
Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital
Application granted granted Critical
Publication of ATE241359T1 publication Critical patent/ATE241359T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT94911001T 1993-03-26 1994-03-28 Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind ATE241359T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/037,225 US5631017A (en) 1993-03-26 1993-03-26 Topical application of buspirone for treatment of pathological conditions associated with immune responses
US08/037,271 US5484788A (en) 1993-03-26 1993-03-26 Buspirone as a systemic immunosuppressant
PCT/US1994/003353 WO1994022448A1 (en) 1993-03-26 1994-03-28 Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses

Publications (1)

Publication Number Publication Date
ATE241359T1 true ATE241359T1 (de) 2003-06-15

Family

ID=26713927

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94911001T ATE241359T1 (de) 1993-03-26 1994-03-28 Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind

Country Status (10)

Country Link
EP (1) EP0690715B1 (de)
JP (1) JPH09502699A (de)
AT (1) ATE241359T1 (de)
AU (1) AU692764B2 (de)
CA (1) CA2159091C (de)
DE (1) DE69432749T2 (de)
DK (1) DK0690715T3 (de)
ES (1) ES2201074T3 (de)
PT (1) PT690715E (de)
WO (1) WO1994022448A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521183A (en) * 1994-08-30 1996-05-28 Allergan Use of 5-HT ligands as anti-pruritic agents
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
EP0942727A1 (de) * 1996-04-08 1999-09-22 Sano Corporation Transdermale abgabevorrichtung für azapironverbindungen
ES2159209T3 (es) * 1998-07-14 2001-09-16 Alcon Lab Inc Uso de acido 11-(3-dimetilaminopropiliden)-6,11-dihidrodibenz(b,e)oxepin-2-acetico y de sus sales farmaceuticamente aceptables para la fabricacion de un medicamento para el tratamiento de trastornos oftalmicos no alergicos y para la prevencion de neovascularizacion ocular.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
JPH05502217A (ja) * 1989-08-21 1993-04-22 ベス　イスラエル　ホスピタル　アソシエーション セロトニン拮抗薬の局所用調製物を使用した、皮膚、眼、および粘膜の過敏症、炎症、および過増殖状態の治療のための方法および組成物
CA2077907C (en) * 1990-03-16 1998-06-09 Richard J. Sharpe Use of spiperone as an immunosuppressant and anti-inflammatory agent
SE513429C2 (sv) * 1992-06-03 2000-09-11 Syntello Inc Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer

Also Published As

Publication number Publication date
DK0690715T3 (da) 2003-09-22
CA2159091C (en) 2006-12-19
EP0690715A1 (de) 1996-01-10
DE69432749D1 (de) 2003-07-03
WO1994022448A1 (en) 1994-10-13
PT690715E (pt) 2003-10-31
CA2159091A1 (en) 1994-10-13
JPH09502699A (ja) 1997-03-18
EP0690715B1 (de) 2003-05-28
DE69432749T2 (de) 2004-04-08
AU692764B2 (en) 1998-06-18
ES2201074T3 (es) 2004-03-16
AU6369294A (en) 1994-10-24
EP0690715A4 (de) 1997-09-03

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