CA2159091C - Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses - Google Patents
Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses Download PDFInfo
- Publication number
- CA2159091C CA2159091C CA002159091A CA2159091A CA2159091C CA 2159091 C CA2159091 C CA 2159091C CA 002159091 A CA002159091 A CA 002159091A CA 2159091 A CA2159091 A CA 2159091A CA 2159091 C CA2159091 C CA 2159091C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- aryl
- buspirone
- group
- c6h4ch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/037,225 US5631017A (en) | 1993-03-26 | 1993-03-26 | Topical application of buspirone for treatment of pathological conditions associated with immune responses |
US08/037,225 | 1993-03-26 | ||
US08/037,271 US5484788A (en) | 1993-03-26 | 1993-03-26 | Buspirone as a systemic immunosuppressant |
US08/037,271 | 1993-03-26 | ||
PCT/US1994/003353 WO1994022448A1 (en) | 1993-03-26 | 1994-03-28 | Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2159091A1 CA2159091A1 (en) | 1994-10-13 |
CA2159091C true CA2159091C (en) | 2006-12-19 |
Family
ID=26713927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002159091A Expired - Fee Related CA2159091C (en) | 1993-03-26 | 1994-03-28 | Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0690715B1 (de) |
JP (1) | JPH09502699A (de) |
AT (1) | ATE241359T1 (de) |
AU (1) | AU692764B2 (de) |
CA (1) | CA2159091C (de) |
DE (1) | DE69432749T2 (de) |
DK (1) | DK0690715T3 (de) |
ES (1) | ES2201074T3 (de) |
PT (1) | PT690715E (de) |
WO (1) | WO1994022448A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521183A (en) * | 1994-08-30 | 1996-05-28 | Allergan | Use of 5-HT ligands as anti-pruritic agents |
US5637314A (en) * | 1995-06-07 | 1997-06-10 | Beth Israel Deaconess Medical Center, Inc. | Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis |
WO1997037659A1 (en) * | 1996-04-08 | 1997-10-16 | Sano Corporation | Transdermal delivery device for azapirone compounds |
EP1037627B1 (de) * | 1998-07-14 | 2001-08-01 | Alcon Laboratories, Inc. | Verwendung von 11-(3-dimethylaminopropyliden)-6,11-dihydrodibenz[b,e]oxepin-2-essigsäure und deren pharmazeutisch annehmbaren salzen zur herstellung eines medikaments zur behandlung nicht-allergisch-bedingten augenentzündungen und zur prevention der okularen neovaskularisation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
US3976776A (en) * | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
US4963557A (en) * | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
ATE135216T1 (de) * | 1989-08-21 | 1996-03-15 | Beth Israel Hospital | Verwendung von spiperone-derivate zur immunosuppression |
CA2077907C (en) * | 1990-03-16 | 1998-06-09 | Richard J. Sharpe | Use of spiperone as an immunosuppressant and anti-inflammatory agent |
SE513429C2 (sv) * | 1992-06-03 | 2000-09-11 | Syntello Inc | Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer |
-
1994
- 1994-03-28 AT AT94911001T patent/ATE241359T1/de not_active IP Right Cessation
- 1994-03-28 WO PCT/US1994/003353 patent/WO1994022448A1/en active IP Right Grant
- 1994-03-28 JP JP6522262A patent/JPH09502699A/ja active Pending
- 1994-03-28 CA CA002159091A patent/CA2159091C/en not_active Expired - Fee Related
- 1994-03-28 DK DK94911001T patent/DK0690715T3/da active
- 1994-03-28 AU AU63692/94A patent/AU692764B2/en not_active Ceased
- 1994-03-28 EP EP94911001A patent/EP0690715B1/de not_active Expired - Lifetime
- 1994-03-28 PT PT94911001T patent/PT690715E/pt unknown
- 1994-03-28 DE DE69432749T patent/DE69432749T2/de not_active Expired - Fee Related
- 1994-03-28 ES ES94911001T patent/ES2201074T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69432749T2 (de) | 2004-04-08 |
ES2201074T3 (es) | 2004-03-16 |
WO1994022448A1 (en) | 1994-10-13 |
AU692764B2 (en) | 1998-06-18 |
DK0690715T3 (da) | 2003-09-22 |
AU6369294A (en) | 1994-10-24 |
EP0690715A1 (de) | 1996-01-10 |
JPH09502699A (ja) | 1997-03-18 |
CA2159091A1 (en) | 1994-10-13 |
EP0690715B1 (de) | 2003-05-28 |
DE69432749D1 (de) | 2003-07-03 |
ATE241359T1 (de) | 2003-06-15 |
EP0690715A4 (de) | 1997-09-03 |
PT690715E (pt) | 2003-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |