ATE153855T1 - Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten - Google Patents

Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten

Info

Publication number
ATE153855T1
ATE153855T1 AT93923372T AT93923372T ATE153855T1 AT E153855 T1 ATE153855 T1 AT E153855T1 AT 93923372 T AT93923372 T AT 93923372T AT 93923372 T AT93923372 T AT 93923372T AT E153855 T1 ATE153855 T1 AT E153855T1
Authority
AT
Austria
Prior art keywords
compositions
treatment
clonidine derivatives
containing prostaglandins
glaucoma containing
Prior art date
Application number
AT93923372T
Other languages
English (en)
Inventor
Louis Desantis Jr
Verney L Sallee
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE153855T1 publication Critical patent/ATE153855T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
AT93923372T 1992-10-13 1993-10-12 Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten ATE153855T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96006592A 1992-10-13 1992-10-13

Publications (1)

Publication Number Publication Date
ATE153855T1 true ATE153855T1 (de) 1997-06-15

Family

ID=25502747

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93923372T ATE153855T1 (de) 1992-10-13 1993-10-12 Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten

Country Status (10)

Country Link
US (3) US5480900A (de)
EP (1) EP0664707B1 (de)
JP (1) JP3002258B2 (de)
AT (1) ATE153855T1 (de)
AU (1) AU674038B2 (de)
CA (1) CA2146127C (de)
DE (1) DE69311361T2 (de)
ES (1) ES2105333T3 (de)
HK (1) HK1007102A1 (de)
WO (1) WO1994008585A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6184250B1 (en) 1993-08-03 2001-02-06 Alcon Laboratories, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
DE4330177A1 (de) * 1993-08-31 1995-03-02 Schering Ag Neue 9-Chlor-prostaglandin-derivate
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
WO1996013267A2 (en) * 1994-10-27 1996-05-09 Allergan Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma
US5631287A (en) * 1994-12-22 1997-05-20 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
WO1998020881A1 (en) * 1996-11-12 1998-05-22 Alcon Laboratories, Inc 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension
CA2276666A1 (en) 1997-03-07 1998-09-11 Alcon Laboratories, Inc. 13-thia prostaglandins for use in glaucoma therapy
SE9702706D0 (sv) * 1997-07-11 1997-07-11 Pharmacia & Upjohn Ab Prostaglandin derivatives devoid of side-effects for the treatment of glaucoma
EP1100491A1 (de) * 1998-07-21 2001-05-23 Merck & Co., Inc. Ophthalmologische zusammenstellungen zur behandlung von ocularer hypertension
US6417228B1 (en) 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
US6160013A (en) * 1998-12-17 2000-12-12 Alcon Laboratories, Inc. 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
US6211226B1 (en) 1998-12-17 2001-04-03 Alcon Laboratories, Inc. 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
WO2000038667A2 (en) * 1998-12-24 2000-07-06 Alcon Laboratories, Inc. Prostaglandin e agonists for treatment of glaucoma
JP4834224B2 (ja) 1999-03-05 2011-12-14 デューク ユニバーシティ C16不飽和fp−選択的プロスタグランジン類縁体
WO2000051979A1 (en) * 1999-03-05 2000-09-08 The Procter & Gamble Company C16 unsaturated fp-selective prostaglandins analogs
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020198210A1 (en) * 2001-05-03 2002-12-26 Allergan Sales Inc. Alpha-2-adrenergic agonist/fatty acid compositions
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
EP1390073A2 (de) * 2001-05-03 2004-02-25 Allergan, Inc. Zusammensetzungen mit verbesserten pharmakokinetischen eigenschaften
US6531504B2 (en) * 2001-05-17 2003-03-11 Allergan, Inc. Prostanoic acid derivatives as agents for lowering intraocular pressure
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
WO2005018646A1 (ja) * 2003-08-21 2005-03-03 Sucampo Ag 眼科用組成物
US8580851B2 (en) 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
EA010595B1 (ru) * 2004-01-05 2008-10-30 Никокс С.А. Производные простагландинов
CA2613748A1 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
WO2010116270A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. Ep2/4 agonists
EP3421030A1 (de) 2009-11-09 2019-01-02 Allergan, Inc. Zusammensetzungen und verfahren zur stimulation des haarwuchses
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
CN103619168B (zh) * 2011-06-29 2015-09-23 宾州研究基金会 用于治疗白血病的组合物、方法和药盒
DK3290024T3 (da) 2011-08-29 2019-06-03 Mati Therapeutics Inc Vedvarende indgivelse af aktive midler til behandling af glaukom og okulær hypertension
CA2872338C (en) 2012-05-03 2021-09-14 Qlt Inc. Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
EP3244851A4 (de) 2015-01-12 2018-08-22 Kedalion Therapeutics, Inc. Vorrichtung zur ausgabe von mikrotropfen und verfahren
US9827225B2 (en) 2016-01-25 2017-11-28 Jenivision Inc. Use of prostacyclin antagonists for treating ocular surface nociception
KR20190104993A (ko) 2016-11-08 2019-09-11 보오슈 앤드 롬 인코포레이팃드 정상 안압 녹내장을 치료하기 위한 산화질소 방출 프로스타글란딘 유도체
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
US11925577B2 (en) 2020-04-17 2024-03-12 Bausch + Lomb Ireland Limted Hydrodynamically actuated preservative free dispensing system

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3190802A (en) * 1961-10-09 1965-06-22 Boehringer Sohn Ingelheim Shaving composition and method of using same
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
US3755426A (en) * 1971-07-02 1973-08-28 American Home Prod 10-haloprostaglandin-a derivatives
GB1444971A (en) * 1972-07-24 1976-08-04 American Cyanamid Co Derivatives of prostanoic acid
US3873607A (en) * 1972-07-24 1975-03-25 American Cyanamid Co 3-Oxa(and thia) 11-deoxy PGE
US4110368A (en) * 1972-07-24 1978-08-29 American Cyanamid Company Hydro substituted prostanoic acids and esters
US3884969A (en) * 1973-04-20 1975-05-20 American Cyanamid Co Novel prostaglandins
US4029681A (en) * 1976-02-13 1977-06-14 The Upjohn Company 13,14-Didehydro-PG analogs
US4321405A (en) * 1976-03-03 1982-03-23 American Cyanamid Company 15,16-Dioxy prostenoic acids and esters
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
US4343949A (en) * 1977-09-22 1982-08-10 American Cyanamid Company Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
US4288616A (en) * 1979-04-02 1981-09-08 The Upjohn Company 13,14-Didehydro-11-deoxy-11-hydroxymethyl-19-oxo-PGF2 compounds
US4291175A (en) * 1980-04-03 1981-09-22 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
NZ200429A (en) * 1981-04-30 1984-10-19 Smith & Nephew Ass Applicator for placing pharmaceutically active agent in contact with moist surface,e.g.,eye
US4730013A (en) * 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
US4614825A (en) * 1982-05-17 1986-09-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane and 7-oxabicycloheptene compounds
US4576962A (en) * 1983-10-19 1986-03-18 The Procter & Gamble Company Prostaglandin analogues
DE3347128A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 9-halogen-(delta)(pfeil hoch)2(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4911920A (en) * 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
US4587257A (en) * 1984-12-14 1986-05-06 Alcon Laboratories, Inc. Control of ocular bleeding using clonidine derivatives
ES2042625T5 (es) * 1987-04-03 2000-07-16 Univ Columbia Uso de una prostaglandina en combinacion con un agente bloqueante adrenergico para la reduccion de presion intraocular.
CA1324129C (en) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
JP2716986B2 (ja) * 1987-07-17 1998-02-18 シエーリング アクチエンゲゼルシヤフト 9‐ハロゲン‐(z)‐プロスタグランジン誘導体、その製法及び薬剤としてのその使用
EP1224935A3 (de) * 1988-09-06 2003-03-26 Pharmacia Aktiebolag Prostaglandoin-Derivate zur Behandlung von Glaukom und ocularer Hypertension
DE68918391T2 (de) * 1988-10-01 1995-01-19 R Tech Ueno Ltd Okulare hypotensive Mittel.
CA2014038A1 (en) * 1989-05-25 1990-11-25 Charles Gluchowski Intraocular pressure reducing 15-acyl prostaglandins
DE3923797A1 (de) * 1989-07-14 1991-01-24 Schering Ag 9-fluor-prostaglandin-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5093329A (en) * 1990-03-12 1992-03-03 Allergan, Inc. Intraocular pressure reducing prostaglandin-like 7-oxabicyclo derivatives
CA2076023A1 (en) * 1990-03-19 1991-09-20 David Frederick Woodward Use of 5-trans prostaglandin f as an ocular hypotensive agent
ES2069823T3 (es) * 1990-05-22 1995-05-16 R Tech Ueno Ltd Tratamiento de la hipertension ocular con una combinacion sinergica ocular.
US5212162A (en) * 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions

Also Published As

Publication number Publication date
JP3002258B2 (ja) 2000-01-24
WO1994008585A1 (en) 1994-04-28
US5480900A (en) 1996-01-02
AU5328694A (en) 1994-05-09
US5811443A (en) 1998-09-22
EP0664707B1 (de) 1997-06-04
JPH08502485A (ja) 1996-03-19
EP0664707A1 (de) 1995-08-02
US5605922A (en) 1997-02-25
ES2105333T3 (es) 1997-10-16
HK1007102A1 (en) 1999-04-01
CA2146127C (en) 2000-06-13
DE69311361T2 (de) 1998-01-08
AU674038B2 (en) 1996-12-05
DE69311361D1 (de) 1997-07-10

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