ES2064356T3 - Azaespiranos inmunomoduladores. - Google Patents

Azaespiranos inmunomoduladores.

Info

Publication number
ES2064356T3
ES2064356T3 ES88308914T ES88308914T ES2064356T3 ES 2064356 T3 ES2064356 T3 ES 2064356T3 ES 88308914 T ES88308914 T ES 88308914T ES 88308914 T ES88308914 T ES 88308914T ES 2064356 T3 ES2064356 T3 ES 2064356T3
Authority
ES
Spain
Prior art keywords
azaspirans
immunomodulating
azaspiranes
formulae
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88308914T
Other languages
English (en)
Inventor
Alison Mary Badger
Michael John Dimartino
Christopher Kevin Mirabelli
Elaine Nicholas Cheeseman
James Woodrow Dorman
Donald Harold Picker
David Aaron Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2064356T3 publication Critical patent/ES2064356T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Ceramic Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A COMMPOSICIONES FARMACEUTICAS QUE CONTIENE AZASPIRANOS INMUNOMODULATORIOS DE LA FORMULA(I) Y (II), EN DONDE N ES 3 A 7, M ES 1 O 2, Y R1 A R6 SON H O ALQUILO. TAMBIEN SE DESCRIBEN NUEVAS AZASPIRINAS UN PROCESO PARA SU PREPARACION.
ES88308914T 1987-09-28 1988-09-26 Azaespiranos inmunomoduladores. Expired - Lifetime ES2064356T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes

Publications (1)

Publication Number Publication Date
ES2064356T3 true ES2064356T3 (es) 1995-02-01

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88308914T Expired - Lifetime ES2064356T3 (es) 1987-09-28 1988-09-26 Azaespiranos inmunomoduladores.

Country Status (24)

Country Link
US (1) US4963557A (es)
EP (1) EP0310321B1 (es)
JP (1) JP2582888B2 (es)
KR (1) KR0166336B1 (es)
CN (1) CN1031618C (es)
AT (1) ATE114463T1 (es)
AU (1) AU619780B2 (es)
CA (1) CA1313189C (es)
CY (1) CY1955A (es)
DE (1) DE3852266T2 (es)
DK (1) DK170042B1 (es)
ES (1) ES2064356T3 (es)
FI (1) FI93006C (es)
GR (1) GR3014931T3 (es)
HK (1) HK1006274A1 (es)
HU (1) HU208809B (es)
IE (1) IE67891B1 (es)
IL (1) IL87908A (es)
MX (1) MX9203765A (es)
NO (1) NO173824C (es)
NZ (1) NZ226354A (es)
PT (1) PT88603B (es)
WO (1) WO1989002889A1 (es)
ZW (1) ZW12388A1 (es)

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EP0542860B1 (en) * 1990-08-10 1998-05-20 AnorMED Inc Immunosuppressive compositions
US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
CA2092177A1 (en) * 1990-09-24 1992-03-25 Alison Mary Badger Methods
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
ATE204743T1 (de) * 1991-12-18 2001-09-15 Minnesota Mining & Mfg Aerosolzusammensetzungen für arzneimittelsuspensionen
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
DE4222459C2 (de) * 1992-07-08 1995-09-14 Sigma Tau Ind Farmaceuti 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
WO1994022448A1 (en) * 1993-03-26 1994-10-13 Beth Israel Hospital Association Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
GB9315271D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315341D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
BG62359B1 (bg) * 1995-07-13 1999-09-30 Anormed N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
JP3195364B2 (ja) * 1995-07-13 2001-08-06 アノーメッド インコーポレイティド Ｎ，ｎ−ジメチル−８，８−ジプロピル−２−アザスピロ〔４．５〕デカン−２−プロパンアミン・ジマレエート
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
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HUP0003908A3 (en) * 1996-05-17 2001-04-28 Anormed Inc Langley Use of substituted azaspirane in the manufacture of a medicament for use in treating asthma
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) * 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
WO2004080408A2 (en) * 2003-03-10 2004-09-23 Callisto Pharmaceuticals, Inc. Method of treating cancer with azaspirane compositions
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
AU2005287037A1 (en) * 2004-09-20 2006-03-30 Targacept, Inc. Azaspiroalkene and azaspiroalkane compounds with nicotinic cholinergic receptor activity
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Also Published As

Publication number Publication date
FI93006B (fi) 1994-10-31
CN1031618C (zh) 1996-04-24
FI901530A0 (fi) 1990-03-27
HK1006274A1 (en) 1999-02-19
NZ226354A (en) 1991-02-26
IE882929L (en) 1989-03-28
GR3014931T3 (en) 1995-05-31
JPH03500290A (ja) 1991-01-24
NO901392D0 (no) 1990-03-27
KR890701562A (ko) 1989-12-20
DK170042B1 (da) 1995-05-08
NO173824C (no) 1994-02-09
DK77090D0 (da) 1990-03-23
DE3852266T2 (de) 1995-05-18
EP0310321B1 (en) 1994-11-30
AU2533388A (en) 1989-04-18
US4963557A (en) 1990-10-16
PT88603A (pt) 1988-10-01
CY1955A (en) 1997-05-16
JP2582888B2 (ja) 1997-02-19
EP0310321A2 (en) 1989-04-05
WO1989002889A1 (en) 1989-04-06
DE3852266D1 (de) 1995-01-12
CN1032437A (zh) 1989-04-19
IL87908A (en) 1993-02-21
PT88603B (pt) 1992-12-31
HU208809B (en) 1995-06-28
AU619780B2 (en) 1992-02-06
NO173824B (no) 1993-11-01
MX9203765A (es) 1992-07-01
ATE114463T1 (de) 1994-12-15
DK77090A (da) 1990-03-23
CA1313189C (en) 1993-01-26
KR0166336B1 (ko) 1999-01-15
NO901392L (no) 1990-03-27
EP0310321A3 (en) 1991-02-06
HU885889D0 (en) 1991-11-28
ZW12388A1 (en) 1989-01-04
FI93006C (fi) 1995-02-10
IL87908A0 (en) 1989-03-31
IE67891B1 (en) 1996-05-01
HUT57722A (en) 1991-12-30

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