SI1863787T1 - Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji - Google Patents

Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji

Info

Publication number
SI1863787T1
SI1863787T1 SI200631088T SI200631088T SI1863787T1 SI 1863787 T1 SI1863787 T1 SI 1863787T1 SI 200631088 T SI200631088 T SI 200631088T SI 200631088 T SI200631088 T SI 200631088T SI 1863787 T1 SI1863787 T1 SI 1863787T1
Authority
SI
Slovenia
Prior art keywords
åthiophene
hydogrenated
immunomodulators
benzo
derivatives
Prior art date
Application number
SI200631088T
Other languages
English (en)
Inventor
Martin Bolli
David Lehmann
Boris Mathys
Claus Mueller
Oliver Nayler
Jorg Velker
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of SI1863787T1 publication Critical patent/SI1863787T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI200631088T 2005-03-23 2006-03-20 Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji SI1863787T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2005003071 2005-03-23
EP06727679A EP1863787B1 (en) 2005-03-23 2006-03-20 Hydogrenated benzo[c]thiophene derivatives as immunomodulators
PCT/IB2006/050845 WO2006100631A1 (en) 2005-03-23 2006-03-20 Hydrogenated benzo (c) thiophene derivatives as immunomodulators

Publications (1)

Publication Number Publication Date
SI1863787T1 true SI1863787T1 (sl) 2011-10-28

Family

ID=36592888

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631088T SI1863787T1 (sl) 2005-03-23 2006-03-20 Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji

Country Status (26)

Country Link
US (2) US7723378B2 (sl)
EP (1) EP1863787B1 (sl)
JP (1) JP5047941B2 (sl)
KR (1) KR101382733B1 (sl)
CN (1) CN101180290B (sl)
AR (1) AR053452A1 (sl)
AT (1) ATE510831T1 (sl)
AU (1) AU2006226018B2 (sl)
BR (1) BRPI0609515A8 (sl)
CA (1) CA2602474C (sl)
CY (1) CY1111767T1 (sl)
DK (1) DK1863787T3 (sl)
ES (1) ES2365747T3 (sl)
HR (1) HRP20110613T1 (sl)
IL (1) IL186148A (sl)
MX (1) MX2007011670A (sl)
MY (1) MY147949A (sl)
NO (1) NO340192B1 (sl)
NZ (1) NZ562562A (sl)
PL (1) PL1863787T3 (sl)
PT (1) PT1863787E (sl)
RU (1) RU2412179C2 (sl)
SI (1) SI1863787T1 (sl)
TW (1) TWI402262B (sl)
WO (1) WO2006100631A1 (sl)
ZA (1) ZA200709088B (sl)

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US7605269B2 (en) * 2005-03-23 2009-10-20 Actelion Pharmaceuticals Ltd. Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
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Also Published As

Publication number Publication date
CA2602474C (en) 2014-06-10
IL186148A (en) 2012-05-31
JP5047941B2 (ja) 2012-10-10
MY147949A (en) 2013-02-15
CN101180290A (zh) 2008-05-14
WO2006100631A1 (en) 2006-09-28
PT1863787E (pt) 2011-07-29
TW200716591A (en) 2007-05-01
TWI402262B (zh) 2013-07-21
US20080176926A1 (en) 2008-07-24
BRPI0609515A8 (pt) 2017-12-26
JP2008534490A (ja) 2008-08-28
CY1111767T1 (el) 2015-10-07
AU2006226018B2 (en) 2012-07-12
RU2412179C2 (ru) 2011-02-20
EP1863787A1 (en) 2007-12-12
US8039644B2 (en) 2011-10-18
CA2602474A1 (en) 2006-09-28
IL186148A0 (en) 2008-01-20
BRPI0609515A2 (pt) 2010-04-13
DK1863787T3 (da) 2011-08-01
US7723378B2 (en) 2010-05-25
RU2007138875A (ru) 2009-04-27
US20100204198A1 (en) 2010-08-12
ES2365747T3 (es) 2011-10-10
PL1863787T3 (pl) 2011-10-31
KR20080003360A (ko) 2008-01-07
NZ562562A (en) 2010-11-26
NO20075299L (no) 2007-12-27
EP1863787B1 (en) 2011-05-25
KR101382733B1 (ko) 2014-04-14
ATE510831T1 (de) 2011-06-15
ZA200709088B (en) 2008-09-25
NO340192B1 (no) 2017-03-20
CN101180290B (zh) 2012-12-12
HRP20110613T1 (hr) 2011-09-30
MX2007011670A (es) 2007-11-15
AR053452A1 (es) 2007-05-09
AU2006226018A1 (en) 2006-09-28

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