DK1863787T3 - Hydrogeneret benzo[c]thiophenderivater som immunmodulatorer - Google Patents
Hydrogeneret benzo[c]thiophenderivater som immunmodulatorerInfo
- Publication number
- DK1863787T3 DK1863787T3 DK06727679.0T DK06727679T DK1863787T3 DK 1863787 T3 DK1863787 T3 DK 1863787T3 DK 06727679 T DK06727679 T DK 06727679T DK 1863787 T3 DK1863787 T3 DK 1863787T3
- Authority
- DK
- Denmark
- Prior art keywords
- immunomodulators
- thiophene derivatives
- benzo
- hydrogenated
- hydrogenated benzo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2005003071 | 2005-03-23 | ||
PCT/IB2006/050845 WO2006100631A1 (en) | 2005-03-23 | 2006-03-20 | Hydrogenated benzo (c) thiophene derivatives as immunomodulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1863787T3 true DK1863787T3 (da) | 2011-08-01 |
Family
ID=36592888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06727679.0T DK1863787T3 (da) | 2005-03-23 | 2006-03-20 | Hydrogeneret benzo[c]thiophenderivater som immunmodulatorer |
Country Status (26)
Country | Link |
---|---|
US (2) | US7723378B2 (da) |
EP (1) | EP1863787B1 (da) |
JP (1) | JP5047941B2 (da) |
KR (1) | KR101382733B1 (da) |
CN (1) | CN101180290B (da) |
AR (1) | AR053452A1 (da) |
AT (1) | ATE510831T1 (da) |
AU (1) | AU2006226018B2 (da) |
BR (1) | BRPI0609515A8 (da) |
CA (1) | CA2602474C (da) |
CY (1) | CY1111767T1 (da) |
DK (1) | DK1863787T3 (da) |
ES (1) | ES2365747T3 (da) |
HR (1) | HRP20110613T1 (da) |
IL (1) | IL186148A (da) |
MX (1) | MX2007011670A (da) |
MY (1) | MY147949A (da) |
NO (1) | NO340192B1 (da) |
NZ (1) | NZ562562A (da) |
PL (1) | PL1863787T3 (da) |
PT (1) | PT1863787E (da) |
RU (1) | RU2412179C2 (da) |
SI (1) | SI1863787T1 (da) |
TW (1) | TWI402262B (da) |
WO (1) | WO2006100631A1 (da) |
ZA (1) | ZA200709088B (da) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4678139B2 (ja) * | 2004-05-10 | 2011-04-27 | トヨタ自動車株式会社 | 自動車の暖房制御システム |
WO2006010379A1 (en) * | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
CA2602478A1 (en) | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
KR20070116645A (ko) * | 2005-03-23 | 2007-12-10 | 액테리온 파마슈티칼 리미티드 | 스핑고신-1-포스페이트-1 수용체 길항제로서의 신규한티오펜 유도체 |
KR20080024533A (ko) * | 2005-06-24 | 2008-03-18 | 액테리온 파마슈티칼 리미티드 | 신규한 티오펜 유도체 |
AR057894A1 (es) | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
EP1979345B1 (en) | 2006-01-24 | 2009-11-04 | Actelion Pharmaceuticals Ltd. | Novel pyridine derivatives |
MX2009002233A (es) | 2006-09-07 | 2009-03-16 | Actelion Pharmaceuticals Ltd | Derivados de piridin-4-il como agentes inmunomoduladores. |
AR061841A1 (es) * | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
KR101454937B1 (ko) * | 2006-09-08 | 2014-10-27 | 액테리온 파마슈티칼 리미티드 | 면역조절제로서 피리딘-3-일 유도체 |
US8044076B2 (en) * | 2006-09-21 | 2011-10-25 | Actelion Pharmaceuticals Ltd. | Phenyl derivatives and their use as immunomodulators |
EP2125797B1 (en) * | 2007-03-16 | 2014-01-15 | Actelion Pharmaceuticals Ltd. | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
ES2403209T3 (es) * | 2007-12-10 | 2013-05-16 | Actelion Pharmaceuticals Ltd. | Derivados de tiofeno novedosos como agonistas de S1P1/EDG1 |
PE20091339A1 (es) * | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
US20110028448A1 (en) * | 2008-03-06 | 2011-02-03 | Martin Bolli | Pyridine compounds |
PL2252609T3 (pl) * | 2008-03-07 | 2013-09-30 | Idorsia Pharmaceuticals Ltd | Pochodne pirydyn-2-ylu jako środki immunomodulujące |
PT2278960T (pt) | 2008-03-17 | 2017-03-09 | Actelion Pharmaceuticals Ltd | Regime de dosagem para um agonista seletivo do recetor s1p1 |
KR20220084423A (ko) | 2008-07-23 | 2022-06-21 | 아레나 파마슈티칼스, 인크. | 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체 |
SI2342205T1 (sl) | 2008-08-27 | 2016-09-30 | Arena Pharmaceuticals, Inc. | Substituirani triciklični kislinski derivati kot agonisti S1P1 receptorja, uporabni v zdravljenju avtoimunskih in vnetnih obolenj |
CN102361867A (zh) | 2009-01-23 | 2012-02-22 | 百时美施贵宝公司 | 在治疗自身免疫疾病和炎性疾病中作为s1p激动剂的取代的噁二唑衍生物 |
US8389509B2 (en) | 2009-01-23 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted pyrazole compounds |
US8404672B2 (en) | 2009-01-23 | 2013-03-26 | Bristol-Meyers Squibb Company | Substituted heterocyclic compounds |
SG178042A1 (en) | 2009-07-16 | 2012-03-29 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
SG10201906876PA (en) | 2010-01-27 | 2019-09-27 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
SG10201501575VA (en) | 2010-03-03 | 2015-04-29 | Arena Pharm Inc | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
JP5869579B2 (ja) | 2010-09-24 | 2016-02-24 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 置換オキサジアゾール化合物およびそれらのs1p1アゴニストとしての使用 |
PT2665720E (pt) | 2011-01-19 | 2015-09-16 | Actelion Pharmaceuticals Ltd | Derivados de 2-metoxi-piridin-4-ilo |
ES2595240T3 (es) | 2012-07-09 | 2016-12-28 | Lupin Limited | Derivados de tetrahidroquinazolinona como inhibidores de PARP |
PT2885266T (pt) | 2012-08-17 | 2020-05-29 | Actelion Pharmaceuticals Ltd | Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo |
CN116850181A (zh) | 2015-01-06 | 2023-10-10 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
EP3298008B1 (en) | 2015-05-20 | 2019-11-20 | Idorsia Pharmaceuticals Ltd | Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
ES2929526T3 (es) | 2015-06-22 | 2022-11-29 | Arena Pharm Inc | Sal cristalina de L-arginina del ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclo-penta[b]indol-3-il)acético para su uso en trastornos asociados al receptor S1P1 |
MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
CA3053416A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
KR20210074291A (ko) | 2018-09-06 | 2021-06-21 | 아레나 파마슈티칼스, 인크. | 자가면역 및 염증성 장애의 치료에 유용한 화합물 |
KR20240018890A (ko) | 2022-08-03 | 2024-02-14 | 이진수 | 절개선을 갖는 종이 원단의 연신 특성을 이용한 과일 트레이 제조방법 및 이로부터 제조된 친환경 과일 트레이 |
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US1989480A (en) * | 1932-06-27 | 1935-01-29 | Associated Patents Inc | Process of preparing cereal foods |
US2000615A (en) * | 1935-03-04 | 1935-05-07 | Chester H Roth | Hosiery |
FR2599740B1 (fr) * | 1986-06-05 | 1988-08-12 | Rhone Poulenc Sante | Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant |
US4963557A (en) | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
AU7686891A (en) | 1990-04-05 | 1991-10-30 | American National Red Cross, The | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
CA2051494C (en) | 1990-09-20 | 2006-03-14 | Robert J. Dinerstein | 1-aryl-3-pyridinyl-2-propene-1-ones as calcium uptake inhibitors |
US6423508B1 (en) | 1998-03-09 | 2002-07-23 | Smithkline Beecham Corporation | Polynucleotide sequences of human EDG-1c |
GB9808665D0 (en) * | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic compounds |
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ATE441654T1 (de) | 2002-01-18 | 2009-09-15 | Merck & Co Inc | Edg-rezeptoragonisten |
EP1575964B1 (en) | 2002-01-18 | 2009-11-11 | Merck & Co., Inc. | N-(benzyl)aminoalkyl carboxylate, phosphinates, phosphonates and tetrazoles as edg receptor agonists |
US20040058894A1 (en) * | 2002-01-18 | 2004-03-25 | Doherty George A. | Selective S1P1/Edg1 receptor agonists |
WO2003105771A2 (en) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
WO2004035538A1 (en) | 2002-10-15 | 2004-04-29 | Merck & Co., Inc. | Process for making azetidine-3-carboxylic acid |
US20060252741A1 (en) | 2003-05-15 | 2006-11-09 | Colandrea Vincent J | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
KR101186386B1 (ko) * | 2003-08-29 | 2012-09-26 | 오노 야꾸힝 고교 가부시키가이샤 | S1p 수용체 결합능을 갖는 화합물 및 그 의약 용도 |
CN1859908A (zh) | 2003-10-01 | 2006-11-08 | 默克公司 | 作为s1p受体激动剂的3,5-芳基、杂芳基或环烷基取代的-1,2,4-噁二唑类化合物 |
CN1894225A (zh) | 2003-12-17 | 2007-01-10 | 默克公司 | 作为鞘氨醇1-磷酸(内皮分化基因)受体激动剂的(3,4-二取代)丙酸酯 |
WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
CA2602478A1 (en) | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
KR20070116645A (ko) | 2005-03-23 | 2007-12-10 | 액테리온 파마슈티칼 리미티드 | 스핑고신-1-포스페이트-1 수용체 길항제로서의 신규한티오펜 유도체 |
AR057894A1 (es) | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
EP1979345B1 (en) | 2006-01-24 | 2009-11-04 | Actelion Pharmaceuticals Ltd. | Novel pyridine derivatives |
GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
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2006
- 2006-03-20 KR KR1020077024309A patent/KR101382733B1/ko not_active IP Right Cessation
- 2006-03-20 EP EP06727679A patent/EP1863787B1/en active Active
- 2006-03-20 WO PCT/IB2006/050845 patent/WO2006100631A1/en active Application Filing
- 2006-03-20 SI SI200631088T patent/SI1863787T1/sl unknown
- 2006-03-20 PL PL06727679T patent/PL1863787T3/pl unknown
- 2006-03-20 PT PT06727679T patent/PT1863787E/pt unknown
- 2006-03-20 US US11/909,429 patent/US7723378B2/en not_active Expired - Fee Related
- 2006-03-20 ES ES06727679T patent/ES2365747T3/es active Active
- 2006-03-20 CA CA2602474A patent/CA2602474C/en not_active Expired - Fee Related
- 2006-03-20 AU AU2006226018A patent/AU2006226018B2/en not_active Ceased
- 2006-03-20 NZ NZ562562A patent/NZ562562A/en not_active IP Right Cessation
- 2006-03-20 MX MX2007011670A patent/MX2007011670A/es active IP Right Grant
- 2006-03-20 RU RU2007138875/04A patent/RU2412179C2/ru not_active IP Right Cessation
- 2006-03-20 DK DK06727679.0T patent/DK1863787T3/da active
- 2006-03-20 AT AT06727679T patent/ATE510831T1/de active
- 2006-03-20 CN CN2006800172389A patent/CN101180290B/zh not_active Expired - Fee Related
- 2006-03-20 BR BRPI0609515A patent/BRPI0609515A8/pt active Search and Examination
- 2006-03-20 JP JP2008502538A patent/JP5047941B2/ja not_active Expired - Fee Related
- 2006-03-21 MY MYPI20061242A patent/MY147949A/en unknown
- 2006-03-22 TW TW095109919A patent/TWI402262B/zh not_active IP Right Cessation
- 2006-03-23 AR ARP060101156A patent/AR053452A1/es unknown
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2007
- 2007-09-20 IL IL186148A patent/IL186148A/en not_active IP Right Cessation
- 2007-10-17 NO NO20075299A patent/NO340192B1/no not_active IP Right Cessation
- 2007-10-22 ZA ZA200709088A patent/ZA200709088B/xx unknown
-
2010
- 2010-03-29 US US12/749,180 patent/US8039644B2/en not_active Expired - Fee Related
-
2011
- 2011-08-19 HR HR20110613T patent/HRP20110613T1/hr unknown
- 2011-08-24 CY CY20111100806T patent/CY1111767T1/el unknown
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