PT2885266T - Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo - Google Patents
Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processoInfo
- Publication number
- PT2885266T PT2885266T PT137793782T PT13779378T PT2885266T PT 2885266 T PT2885266 T PT 2885266T PT 137793782 T PT137793782 T PT 137793782T PT 13779378 T PT13779378 T PT 13779378T PT 2885266 T PT2885266 T PT 2885266T
- Authority
- PT
- Portugal
- Prior art keywords
- propylimino
- dihydroxypropoxy
- thiazolidin
- benzylidene
- tolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/77—Preparation of chelates of aldehydes or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12180920 | 2012-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2885266T true PT2885266T (pt) | 2020-05-29 |
Family
ID=46940231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137793782T PT2885266T (pt) | 2012-08-17 | 2013-08-15 | Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9340518B2 (pt) |
| EP (1) | EP2885266B1 (pt) |
| JP (2) | JP6322630B2 (pt) |
| KR (1) | KR101731739B1 (pt) |
| CN (1) | CN104540800B (pt) |
| CA (1) | CA2895172C (pt) |
| CY (1) | CY1123300T1 (pt) |
| DK (1) | DK2885266T3 (pt) |
| ES (1) | ES2795105T3 (pt) |
| HR (1) | HRP20200883T1 (pt) |
| HU (1) | HUE050733T2 (pt) |
| IL (1) | IL237198A (pt) |
| LT (1) | LT2885266T (pt) |
| MX (1) | MX350891B (pt) |
| PL (1) | PL2885266T3 (pt) |
| PT (1) | PT2885266T (pt) |
| RS (1) | RS60408B1 (pt) |
| SI (1) | SI2885266T1 (pt) |
| TW (1) | TWI606036B (pt) |
| WO (1) | WO2014027330A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009115954A1 (en) | 2008-03-17 | 2009-09-24 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
| PT2885266T (pt) * | 2012-08-17 | 2020-05-29 | Actelion Pharmaceuticals Ltd | Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo |
| MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
| AU2015359346B2 (en) | 2014-12-11 | 2020-05-07 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective S1P1 receptor agonist |
| US10487064B1 (en) | 2015-12-25 | 2019-11-26 | Crystal Pharmatech Co., Ltd. | Crystalline forms of selective S1P1 receptor modulator and preparation method thereof |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| WO2019060147A1 (en) * | 2017-09-19 | 2019-03-28 | Teva Pharmaceuticals Usa, Inc. | NEW CRYSTALLINE POLYMORPHE FROM PONESIMOD |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| KR102365655B1 (ko) | 2018-11-29 | 2022-02-22 | 원광대학교 산학협력단 | 콩 발효 추출물을 유효성분으로 포함하는 피부 주름 예방 또는 개선용 조성물 |
| CA3156298A1 (en) | 2019-10-31 | 2021-05-06 | Laetitia POUZOL | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
| WO2023022896A1 (en) | 2021-08-17 | 2023-02-23 | Teva Czech Industries S.R.O | Polymorphs of ponesimod |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023152691A1 (en) * | 2022-02-10 | 2023-08-17 | Metrochem Api Pvt Ltd | Process for the preparation of ponesimod and its intermediates thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3077402A (en) | 1954-12-06 | 1963-02-12 | Polaroid Corp | Photographic color processes, products, and compositions |
| NL270002A (pt) | 1960-10-08 | |||
| GB1001479A (en) | 1962-10-10 | 1965-08-18 | Angeli Inst Spa | Glycerol ethers |
| OA03835A (fr) | 1970-07-17 | 1971-12-24 | Rhone Poulenc Sa | Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent. |
| HU214872B (hu) | 1990-04-27 | 1998-07-28 | Orion-Yhtymä Oy | Eljárás farmakológiailag aktív új katecholszármazékok és ezeket tartalmazó gyógyászati készítmények előállítására |
| TW221689B (pt) | 1991-08-27 | 1994-03-11 | Otsuka Pharma Co Ltd | |
| CA2134347C (en) | 1993-02-26 | 2003-04-29 | Koichi Yasumura | Thiazole or imidazole derivatives as maillard reaction inhibitors |
| KR960022486A (ko) | 1994-12-29 | 1996-07-18 | 김준웅 | 신규 티아졸리딘-4-온 유도체 |
| US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| AU6877300A (en) | 1999-09-14 | 2001-04-17 | Shionogi & Co., Ltd. | 2-imino-1,3-thiazine derivatives |
| DE69934027T2 (de) | 1999-11-12 | 2007-06-21 | Fujimoto Brothers Co., Ltd., Matubara | 2-(n-cyanimino)thiazolidin-4-on derivate |
| US20050019825A9 (en) | 2002-03-15 | 2005-01-27 | Qing Dong | Common ligand mimics: pseudothiohydantoins |
| AU2003255528B2 (en) | 2002-07-10 | 2009-07-16 | Merck Serono Sa | Azolidinone-vinyl fused-benzene derivatives |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| WO2004014313A2 (en) | 2002-08-12 | 2004-02-19 | Bristol-Myers Squibb Company | Combination pharmaceutical agents as inhibitors of hcv replication |
| KR20050085115A (ko) | 2002-11-22 | 2005-08-29 | 스미스클라인 비참 코포레이션 | 신규 화합물 |
| US20040167192A1 (en) | 2003-01-16 | 2004-08-26 | David Solow-Cordero | Methods of treating conditions associated with an Edg-7 receptor |
| US7892354B2 (en) | 2003-10-06 | 2011-02-22 | Solvias Ag | Process for the parallel detection of crystalline forms of molecular solids |
| DE602004029493D1 (de) | 2003-11-21 | 2010-11-18 | Actelion Pharmaceuticals Ltd | 5-(benz- (z) -yliden) -thiazolidin-4-onderivate als das immunsystem unterdrückende mittel |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| JP2007523957A (ja) | 2004-02-25 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | 新規化学化合物 |
| WO2005123677A1 (en) | 2004-06-16 | 2005-12-29 | Actelion Pharmaceuticals Ltd | 4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents |
| WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
| JP2008521827A (ja) | 2004-11-29 | 2008-06-26 | ノバルティス アクチエンゲゼルシャフト | Ｓ１ｐ受容体アゴニストの投与レジメン |
| WO2006094233A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N,n'-dicyclic isothiourea sirtuin modulators |
| JP5047941B2 (ja) | 2005-03-23 | 2012-10-10 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節物質としての水素付加されたベンゾ（ｃ）チオフェン誘導体 |
| RU2404178C2 (ru) | 2005-03-23 | 2010-11-20 | Актелион Фармасьютиклз Лтд | Новые производные тиофена в качестве агонистов рецептора сфингозин-1-фосфата-1 |
| CN101180050B (zh) | 2005-03-23 | 2011-07-27 | 埃科特莱茵药品有限公司 | 作为鞘氨醇-1-磷酸盐-1受体激动剂的新颖噻吩衍生物 |
| AU2006260573A1 (en) | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives |
| AR057894A1 (es) | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
| TWI404706B (zh) | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| EP1979345B1 (en) | 2006-01-24 | 2009-11-04 | Actelion Pharmaceuticals Ltd. | Novel pyridine derivatives |
| US7879821B2 (en) | 2006-01-26 | 2011-02-01 | University Of Medicine And Dentistry Of New Jersey | Method for modulating inflammatory responses by altering plasma lipid levels |
| AU2007292993B2 (en) | 2006-09-07 | 2013-01-24 | Idorsia Pharmaceuticals Ltd | Pyridin-4-yl derivatives as immunomodulating agents |
| AR061841A1 (es) | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
| CA2661315C (en) | 2006-09-08 | 2015-11-24 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
| RU2442780C2 (ru) | 2006-09-21 | 2012-02-20 | Актелион Фармасьютиклз Лтд | Фенильные производные и их применение в качестве иммуномодуляторов |
| DK2094676T3 (da) | 2006-11-23 | 2013-06-10 | Actelion Pharmaceuticals Ltd | Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| DK2125797T3 (da) | 2007-03-16 | 2014-02-10 | Actelion Pharmaceuticals Ltd | Aminopyridinderivater som s1p1/edg1-receptoragonister |
| SI2195311T1 (sl) | 2007-08-17 | 2011-07-29 | Actelion Pharmaceuticals Ltd | Derivati piridina kot modulatorji receptorja s1p1/edg1 |
| WO2009115954A1 (en) | 2008-03-17 | 2009-09-24 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
| GB0819182D0 (en) * | 2008-10-20 | 2008-11-26 | Actelion Pharmaceuticals Ltd | Crystalline forms |
| US20100160369A1 (en) | 2008-12-04 | 2010-06-24 | Exelixis, Inc. | S1P1 Agonists and Methods of Making And Using |
| PL2379069T3 (pl) | 2008-12-22 | 2015-08-31 | Novartis Ag | Schemat dawkowania agonisty receptora S1P |
| SI3409274T1 (sl) | 2008-12-22 | 2020-03-31 | Novartis Ag | Režim odmerjanja za S1P receptor agonist |
| PT2885266T (pt) * | 2012-08-17 | 2020-05-29 | Actelion Pharmaceuticals Ltd | Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo |
-
2013
- 2013-08-15 PT PT137793782T patent/PT2885266T/pt unknown
- 2013-08-15 CA CA2895172A patent/CA2895172C/en active Active
- 2013-08-15 EP EP13779378.2A patent/EP2885266B1/en active Active
- 2013-08-15 KR KR1020157006474A patent/KR101731739B1/ko active IP Right Grant
- 2013-08-15 CN CN201380042658.2A patent/CN104540800B/zh active Active
- 2013-08-15 PL PL13779378T patent/PL2885266T3/pl unknown
- 2013-08-15 HU HUE13779378A patent/HUE050733T2/hu unknown
- 2013-08-15 ES ES13779378T patent/ES2795105T3/es active Active
- 2013-08-15 LT LTEP13779378.2T patent/LT2885266T/lt unknown
- 2013-08-15 DK DK13779378.2T patent/DK2885266T3/da active
- 2013-08-15 RS RS20200642A patent/RS60408B1/sr unknown
- 2013-08-15 US US14/422,167 patent/US9340518B2/en active Active
- 2013-08-15 JP JP2015527061A patent/JP6322630B2/ja active Active
- 2013-08-15 MX MX2015002127A patent/MX350891B/es active IP Right Grant
- 2013-08-15 SI SI201331742T patent/SI2885266T1/sl unknown
- 2013-08-15 WO PCT/IB2013/056662 patent/WO2014027330A1/en active Application Filing
- 2013-08-16 TW TW102129570A patent/TWI606036B/zh active
-
2015
- 2015-02-12 IL IL237198A patent/IL237198A/en active IP Right Grant
-
2017
- 2017-04-13 JP JP2017079804A patent/JP6424250B2/ja active Active
-
2020
- 2020-06-02 HR HRP20200883TT patent/HRP20200883T1/hr unknown
- 2020-06-11 CY CY20201100532T patent/CY1123300T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI606036B (zh) | 2017-11-21 |
| HUE050733T2 (hu) | 2021-01-28 |
| IL237198A0 (en) | 2015-04-30 |
| CY1123300T1 (el) | 2021-12-31 |
| JP2017160223A (ja) | 2017-09-14 |
| KR101731739B1 (ko) | 2017-05-11 |
| KR20150042277A (ko) | 2015-04-20 |
| US9340518B2 (en) | 2016-05-17 |
| PL2885266T3 (pl) | 2020-11-16 |
| JP6424250B2 (ja) | 2018-11-14 |
| EP2885266A1 (en) | 2015-06-24 |
| MX2015002127A (es) | 2015-05-11 |
| US20150203459A1 (en) | 2015-07-23 |
| DK2885266T3 (da) | 2020-06-08 |
| SI2885266T1 (sl) | 2020-10-30 |
| CA2895172C (en) | 2020-08-18 |
| CA2895172A1 (en) | 2014-02-20 |
| CN104540800B (zh) | 2017-05-10 |
| EP2885266B1 (en) | 2020-03-18 |
| CN104540800A (zh) | 2015-04-22 |
| LT2885266T (lt) | 2020-07-10 |
| RS60408B1 (sr) | 2020-07-31 |
| WO2014027330A1 (en) | 2014-02-20 |
| JP6322630B2 (ja) | 2018-05-09 |
| IL237198A (en) | 2017-12-31 |
| TW201408634A (zh) | 2014-03-01 |
| ES2795105T3 (es) | 2020-11-20 |
| HRP20200883T1 (hr) | 2020-09-04 |
| MX350891B (es) | 2017-09-22 |
| JP2015530373A (ja) | 2015-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2885266T (pt) | Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo | |
| BR112015002541A2 (pt) | composto, composição farmacêutica, uso de um composto, e, método para tratamento de hcv em um paciente. | |
| BR112015003397A2 (pt) | composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente. | |
| BR112015003332A2 (pt) | composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente | |
| BR112015003398A2 (pt) | composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente | |
| BR112014010177A2 (pt) | composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou tratamento de um estado ou uma condição de doença | |
| BR112014010206A2 (pt) | composto, composição farmacêutica, uso de composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença | |
| BR112014010179A2 (pt) | composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição | |
| HK1199712A1 (en) | 18-methyl-6,7-methylene-3-oxo-17-pregn-4-ene-21,17-carbolactones, pharmaceutical preparations comprising said compounds and use thereof in the treatment of endometriosis 18--67--3--17--4--2117- | |
| EP2851429A4 (en) | PROTEIN AND PROTEIN CONJUGATES FOR THE TREATMENT OF DIABETES AND APPLICATIONS THEREOF | |
| HK1216146A1 (zh) | 眼藥組合物、其製備方法及用途 | |
| BR112015031979A2 (pt) | letermovir, formulação farmacêutica oral sólida, uso de uma formulação farmacêutica oral sólida, e processo para preparar letermovir. | |
| IL239940B (en) | History of 2-[3-(diazolyl)phenyl]-3,1-thiazole-5-carboxylic acid and intermediates obtained in the process for their preparation | |
| EP3403675A4 (en) | VIRION ADENO-ASSOCIATED VIRAL FOR ITS USE IN THE TREATMENT OF EPILEPSY | |
| BR112013022523A2 (pt) | uso de glicopirrolato para o tratamento de taquicardia | |
| HRP20181282T1 (hr) | Farmaceutski pripravak ibuprofena i tramadola, namijenjen očnoj upotrebi | |
| CL2014003525A1 (es) | Composicion farmaceutica que comprende fimasartan, hidroclorotiazida y un aglutinante; procedimiento de preparacion; su uso en el tratamiento de hipertension. | |
| BR112015012443A2 (pt) | composição de limpeza, método de limpeza do corpo humano, uso da composição e método para prover limpeza | |
| BR112014025416A2 (pt) | AGENTES ANTIMALÁRICOS, COMPOSIÇÃO FARMACEUTICA COMPREENDENDO-OS E USO Dos MESMOS. | |
| BR112013006857A2 (pt) | composição farmacêutica, processo para preparar uma composição farmacêutica, uso de uma composição farmacêutica e método para o tratamento ou profilaxia de doenças virais | |
| BR112014030949A2 (pt) | "composição, processo para o tratamento cosmético e uso de uma composição" | |
| EP3476864A4 (en) | ANTIBODIES AGAINST ETAR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | |
| EP3328388A4 (en) | PHARMACEUTICAL PREPARATION FOR IMPROVING THE INPUT AND POSTPRANDIAL HYPOGLYKEMIC EFFECT OF INSULIN | |
| EP3175851A4 (en) | Use of butenylphthalide, usage method thereof and method for preparing same into pharmaceutical composition | |
| BR112015001169A2 (pt) | polimorfo, uso do polimorfo, composição farmacêutica e uso para preparar o polimorfo |