GB1001479A - Glycerol ethers - Google Patents

Glycerol ethers

Info

Publication number
GB1001479A
GB1001479A GB3840762A GB3840762A GB1001479A GB 1001479 A GB1001479 A GB 1001479A GB 3840762 A GB3840762 A GB 3840762A GB 3840762 A GB3840762 A GB 3840762A GB 1001479 A GB1001479 A GB 1001479A
Authority
GB
United Kingdom
Prior art keywords
acyl
compounds
hydroxy
hydrogen
glycerol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3840762A
Inventor
Silvano Casadio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto de Angeli SpA
Original Assignee
Instituto de Angeli SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto de Angeli SpA filed Critical Instituto de Angeli SpA
Priority to GB3840762A priority Critical patent/GB1001479A/en
Priority to CH1211763A priority patent/CH441368A/en
Priority to BR15353763A priority patent/BR6353537D0/en
Priority to DE1963J0024533 priority patent/DE1237131B/en
Publication of GB1001479A publication Critical patent/GB1001479A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of general formula <FORM:1001479/C2/1> wherein R1, R2, R3 and R4 represent hydrogen, halogen, hydroxy, alkyl, alkoxy or acyl, at least one being acyl, and R3 not being acyl when R1 and R4 are hydrogen and R2 is hydroxy; and their preparation by reaction of an appropriate phenol or its salt with glycerol or a reactive derivative thereof. Pharmaceutical compositions comprise compounds of the invention with carriers or excipients. Preparations (syrups, drops, elixirs, solutions, powders, granules, tablets, dragees, cachets, pills, capsules, suppositories) are mentioned for oral, parenteral and rectal administration. The compounds are tranquillizers and muscle relaxants.
GB3840762A 1962-10-10 1962-10-10 Glycerol ethers Expired GB1001479A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB3840762A GB1001479A (en) 1962-10-10 1962-10-10 Glycerol ethers
CH1211763A CH441368A (en) 1962-10-10 1963-10-02 Process for the production of glycerol ethers
BR15353763A BR6353537D0 (en) 1962-10-10 1963-10-09 PROCESS FOR THE PREPARATION OF ACYL-FENOIS GLYCEROLIC ETHERS
DE1963J0024533 DE1237131B (en) 1962-10-10 1963-10-09 Process for the production of glycerine ethers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3840762A GB1001479A (en) 1962-10-10 1962-10-10 Glycerol ethers

Publications (1)

Publication Number Publication Date
GB1001479A true GB1001479A (en) 1965-08-18

Family

ID=10403260

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3840762A Expired GB1001479A (en) 1962-10-10 1962-10-10 Glycerol ethers

Country Status (4)

Country Link
BR (1) BR6353537D0 (en)
CH (1) CH441368A (en)
DE (1) DE1237131B (en)
GB (1) GB1001479A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837336A (en) * 1985-10-23 1989-06-06 Glaxo Group Limited Process for preparing heterocyclic compounds
JP2015530373A (en) * 2012-08-17 2015-10-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Of (2Z, 5Z) -5- (3-chloro-4-((R) -2,3-dihydroxypropoxy) benzylidene) -2- (propylimino) -3- (o-tolyl) thiazolidin-4-one Production method and intermediate used in said method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE838002C (en) * 1952-03-27 CILAG Aktiengesellschaft, Schaffhausen (Schweiz) Process for the production of phenolic ethers
DE956041C (en) * 1954-08-25 1957-01-10 Riedel De Haeen Ag Process for the production of new glycerol-ª-phenylether with muscle-relaxing effect

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837336A (en) * 1985-10-23 1989-06-06 Glaxo Group Limited Process for preparing heterocyclic compounds
JP2015530373A (en) * 2012-08-17 2015-10-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Of (2Z, 5Z) -5- (3-chloro-4-((R) -2,3-dihydroxypropoxy) benzylidene) -2- (propylimino) -3- (o-tolyl) thiazolidin-4-one Production method and intermediate used in said method
US9340518B2 (en) 2012-08-17 2016-05-17 Actelion Pharmaceuticals Ltd. Process for the preparation of (2Z,5Z)-5-(3-chloro-4-((R)-2,3-dihydroxypropdxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process
EP2885266B1 (en) * 2012-08-17 2020-03-18 Actelion Pharmaceuticals Ltd Process for the preparation of (2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process

Also Published As

Publication number Publication date
CH441368A (en) 1967-08-15
BR6353537D0 (en) 1973-07-12
DE1237131B (en) 1967-03-23

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