CY1123300T1 - Διαδικασια για την παρασκευη της (2ζ,5ζ)-5-(3-χλωρο-4-((r)-2,3-διυδροξυπροποξυ)βενζυλιδενο)-2-(προπυλιμινο)-3-(ο-τολυλο)θειαζολιδιν-4-ονης και ενδιαμεσου που χρησιμοποιηθηκε στην εν λογω διαδικασια - Google Patents

Διαδικασια για την παρασκευη της (2ζ,5ζ)-5-(3-χλωρο-4-((r)-2,3-διυδροξυπροποξυ)βενζυλιδενο)-2-(προπυλιμινο)-3-(ο-τολυλο)θειαζολιδιν-4-ονης και ενδιαμεσου που χρησιμοποιηθηκε στην εν λογω διαδικασια

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Publication number
CY1123300T1
CY1123300T1 CY20201100532T CY201100532T CY1123300T1 CY 1123300 T1 CY1123300 T1 CY 1123300T1 CY 20201100532 T CY20201100532 T CY 20201100532T CY 201100532 T CY201100532 T CY 201100532T CY 1123300 T1 CY1123300 T1 CY 1123300T1
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CY
Cyprus
Prior art keywords
dihydroxypropoxy
chloro
propylimino
tolyl
preparation
Prior art date
Application number
CY20201100532T
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English (en)
Inventor
Christelle HERSE
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Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of CY1123300T1 publication Critical patent/CY1123300T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/77—Preparation of chelates of aldehydes or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μια νέα διαδικασία για την παρασκευή της (2Ζ,5Ζ)-5-(3-χλωρο-4-((R)-2,3-διυδροξυπροποξυ)βενζυλιδενο)-2-(προπυλιμινο)-3-(ο-τολυλο) θειαζολιδιν-4-όνης και προς το νέο ενδιάμεσο (R)-3-χλωρο-4-(2,3-διυδροξυπροποξυ)-βενζαλδεΰδη που χρησιμοποιείται σε αυτή τη διαδικασία. Η (2Ζ,5Ζ)-5-(3-χλωρο-4-{(R)-2,3-διυδροξυπροποξυ)βενζυλιδενο)-2-(προπυλιμινο)-3-(ο-τολυλο) θειαζολιδιν-4-όνη περιγράφεται στο WO 2005/054215 ότι δρα ως ανοσοκατασταλτικός παράγοντας. Η παρούσα εφεύρεση αναφέρεται επίσης σε μια νέα διαδικασία για την παρασκευή της (R)-3-χλωρο-4-(2,3-διυδροξυπροποξυ)-βενζαλδεύδης.
CY20201100532T 2012-08-17 2020-06-11 Διαδικασια για την παρασκευη της (2ζ,5ζ)-5-(3-χλωρο-4-((r)-2,3-διυδροξυπροποξυ)βενζυλιδενο)-2-(προπυλιμινο)-3-(ο-τολυλο)θειαζολιδιν-4-ονης και ενδιαμεσου που χρησιμοποιηθηκε στην εν λογω διαδικασια CY1123300T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12180920 2012-08-17
PCT/IB2013/056662 WO2014027330A1 (en) 2012-08-17 2013-08-15 Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process
EP13779378.2A EP2885266B1 (en) 2012-08-17 2013-08-15 Process for the preparation of (2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process

Publications (1)

Publication Number Publication Date
CY1123300T1 true CY1123300T1 (el) 2021-12-31

Family

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Application Number Title Priority Date Filing Date
CY20201100532T CY1123300T1 (el) 2012-08-17 2020-06-11 Διαδικασια για την παρασκευη της (2ζ,5ζ)-5-(3-χλωρο-4-((r)-2,3-διυδροξυπροποξυ)βενζυλιδενο)-2-(προπυλιμινο)-3-(ο-τολυλο)θειαζολιδιν-4-ονης και ενδιαμεσου που χρησιμοποιηθηκε στην εν λογω διαδικασια

Country Status (20)

Country Link
US (1) US9340518B2 (el)
EP (1) EP2885266B1 (el)
JP (2) JP6322630B2 (el)
KR (1) KR101731739B1 (el)
CN (1) CN104540800B (el)
CA (1) CA2895172C (el)
CY (1) CY1123300T1 (el)
DK (1) DK2885266T3 (el)
ES (1) ES2795105T3 (el)
HR (1) HRP20200883T1 (el)
HU (1) HUE050733T2 (el)
IL (1) IL237198A (el)
LT (1) LT2885266T (el)
MX (1) MX350891B (el)
PL (1) PL2885266T3 (el)
PT (1) PT2885266T (el)
RS (1) RS60408B1 (el)
SI (1) SI2885266T1 (el)
TW (1) TWI606036B (el)
WO (1) WO2014027330A1 (el)

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Also Published As

Publication number Publication date
PT2885266T (pt) 2020-05-29
MX2015002127A (es) 2015-05-11
IL237198A0 (en) 2015-04-30
CA2895172A1 (en) 2014-02-20
ES2795105T3 (es) 2020-11-20
TWI606036B (zh) 2017-11-21
HRP20200883T1 (hr) 2020-09-04
MX350891B (es) 2017-09-22
TW201408634A (zh) 2014-03-01
JP2015530373A (ja) 2015-10-15
CA2895172C (en) 2020-08-18
LT2885266T (lt) 2020-07-10
RS60408B1 (sr) 2020-07-31
WO2014027330A1 (en) 2014-02-20
JP6424250B2 (ja) 2018-11-14
JP2017160223A (ja) 2017-09-14
JP6322630B2 (ja) 2018-05-09
KR20150042277A (ko) 2015-04-20
US9340518B2 (en) 2016-05-17
PL2885266T3 (pl) 2020-11-16
EP2885266B1 (en) 2020-03-18
CN104540800A (zh) 2015-04-22
EP2885266A1 (en) 2015-06-24
SI2885266T1 (sl) 2020-10-30
HUE050733T2 (hu) 2021-01-28
US20150203459A1 (en) 2015-07-23
KR101731739B1 (ko) 2017-05-11
DK2885266T3 (da) 2020-06-08
IL237198A (en) 2017-12-31
CN104540800B (zh) 2017-05-10

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