CY1113386T1 - Αναστολεις πρωτεασωματος - Google Patents

Αναστολεις πρωτεασωματος

Info

Publication number
CY1113386T1
CY1113386T1 CY20121100845T CY121100845T CY1113386T1 CY 1113386 T1 CY1113386 T1 CY 1113386T1 CY 20121100845 T CY20121100845 T CY 20121100845T CY 121100845 T CY121100845 T CY 121100845T CY 1113386 T1 CY1113386 T1 CY 1113386T1
Authority
CY
Cyprus
Prior art keywords
projector
suspensions
treatment
methods
present
Prior art date
Application number
CY20121100845T
Other languages
English (en)
Inventor
Edward J Olhava
Miheala D Danca
Original Assignee
Millennium Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113386(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharmaceuticals, Inc. filed Critical Millennium Pharmaceuticals, Inc.
Publication of CY1113386T1 publication Critical patent/CY1113386T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει νέες ενώσεις χρήσιμες ως αναστολείς πρωτεασωμάτων. Επίσης, η εφεύρεση παρέχει φαρμακευτικές συνθέσεις που περιέχουν τις ενώσεις της εφεύρεσης και μεθόδους για τη χρήση των συνθέσεων στην αντιμετώπιση διαφόρων διαταραχών.
CY20121100845T 2007-08-06 2012-09-17 Αναστολεις πρωτεασωματος CY1113386T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2007/017440 WO2009020448A1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors
EP07811087A EP2178888B1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors

Publications (1)

Publication Number Publication Date
CY1113386T1 true CY1113386T1 (el) 2016-06-22

Family

ID=38691782

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20121100845T CY1113386T1 (el) 2007-08-06 2012-09-17 Αναστολεις πρωτεασωματος
CY2017016C CY2017016I1 (el) 2007-08-06 2017-04-26 Αναστολεις πρωτεασωματος

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2017016C CY2017016I1 (el) 2007-08-06 2017-04-26 Αναστολεις πρωτεασωματος

Country Status (33)

Country Link
EP (3) EP2178888B1 (el)
JP (1) JP5261488B2 (el)
KR (6) KR20150010802A (el)
CN (1) CN101772507B (el)
AU (1) AU2007357338B2 (el)
BR (1) BRPI0721905B8 (el)
CA (1) CA2695082C (el)
CY (2) CY1113386T1 (el)
DK (1) DK2178888T3 (el)
EA (1) EA028622B1 (el)
EC (1) ECSP10010015A (el)
ES (1) ES2390606T3 (el)
FR (1) FR17C1011I2 (el)
GE (1) GEP20125599B (el)
HK (2) HK1143595A1 (el)
HR (1) HRP20120745T1 (el)
HU (1) HUS1700018I1 (el)
IL (4) IL203641A (el)
LT (1) LTC2178888I2 (el)
LU (1) LUC00013I2 (el)
MY (1) MY161991A (el)
NL (1) NL300871I2 (el)
NZ (1) NZ582693A (el)
PH (1) PH12014500053B1 (el)
PL (1) PL2178888T3 (el)
PT (1) PT2178888E (el)
RS (1) RS52435B (el)
SG (1) SG10201508712QA (el)
SI (1) SI2178888T1 (el)
TN (1) TN2010000060A1 (el)
UA (1) UA97536C2 (el)
WO (1) WO2009020448A1 (el)
ZA (1) ZA201000348B (el)

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US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
AU2006311584B2 (en) 2005-11-09 2012-03-08 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
AU2007261345B2 (en) 2006-06-19 2012-02-23 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
KR20170125413A (ko) 2007-10-04 2017-11-14 오닉스 세라퓨틱스, 인크. 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
GEP20135847B (en) 2008-06-17 2013-06-10 Millennium Pharm Inc Boronate ester compounds and pharmaceutical compositions containing them
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
CA2741312C (en) 2008-10-21 2020-10-27 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
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JP5919196B2 (ja) 2009-11-13 2016-05-18 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 転移抑制のためのペプチドエポキシケトンの使用
WO2011087822A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
SG183843A1 (en) 2010-03-01 2012-10-30 Onyx Therapeutics Inc Compounds for immunoproteasome inhibition
EA029521B1 (ru) 2010-03-31 2018-04-30 Милленниум Фармасьютикалз, Инк. Производные 1-амино-2-циклопропилэтилбороновой кислоты
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EP4144354A1 (en) * 2011-08-30 2023-03-08 Trustees Of Tufts College Fap-activated proteasome inhibitors for treating solid tumors
EP2793900B1 (en) * 2011-12-22 2018-08-22 Ares Trading S.A. Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
US20140357596A1 (en) * 2012-01-24 2014-12-04 Millennium Pharmaceuticals, Inc. Method of treatment of nasopharyngeal cancer
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JP2015524394A (ja) 2012-07-09 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ
CN109096370B (zh) * 2012-07-26 2022-03-18 圣特莱国际公司 多肽环氧酮化合物
JP2013006855A (ja) * 2012-09-03 2013-01-10 Millennium Pharmaceuticals Inc プロテアソーム阻害剤
JP6018319B2 (ja) * 2012-12-03 2016-11-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 置換トリアゾールボロン酸化合物
WO2015051067A1 (en) 2013-10-03 2015-04-09 Millennium Pharmaceuticals, Inc. Method for the prophylaxis or treatment of systemic lupus erythematosus and/or lupus nephritis
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CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
BRPI0721905A2 (pt) 2014-02-25
IL242291A (en) 2017-12-31
GEP20125599B (en) 2012-08-10
EA201070247A1 (ru) 2010-06-30
KR20170004031A (ko) 2017-01-10
AU2007357338B2 (en) 2014-03-20
PT2178888E (pt) 2012-10-04
CY2017016I2 (el) 2017-07-12
WO2009020448A1 (en) 2009-02-12
HRP20120745T1 (hr) 2012-10-31
LTPA2017010I1 (lt) 2017-05-10
SI2178888T1 (sl) 2012-11-30
CY2017016I1 (el) 2017-07-12
EP2178888A1 (en) 2010-04-28
DK2178888T3 (da) 2012-10-01
LTC2178888I2 (lt) 2018-03-12
EP2527347A1 (en) 2012-11-28
KR20140042933A (ko) 2014-04-07
EP3210987A1 (en) 2017-08-30
BRPI0721905B8 (pt) 2021-05-25
NL300871I2 (nl) 2017-12-07
SG10201508712QA (en) 2015-11-27
LUC00013I2 (el) 2017-06-19
FR17C1011I1 (el) 2017-05-26
CN101772507B (zh) 2012-12-12
KR20100059811A (ko) 2010-06-04
IL203641A (en) 2015-11-30
ECSP10010015A (es) 2010-04-30
HK1182924A1 (zh) 2013-12-13
IL242291A0 (en) 2015-11-30
IL242290A (en) 2017-12-31
CA2695082A1 (en) 2009-02-12
IL242290A0 (en) 2015-11-30
NZ582693A (en) 2012-01-12
ZA201000348B (en) 2011-03-30
AU2007357338A1 (en) 2009-02-12
LUC00013I1 (el) 2017-04-06
PL2178888T3 (pl) 2012-11-30
CA2695082C (en) 2015-07-28
CN101772507A (zh) 2010-07-07
IL242292A (en) 2017-12-31
KR101831674B1 (ko) 2018-02-23
KR20140042932A (ko) 2014-04-07
RS52435B (en) 2013-02-28
PH12014500053A1 (en) 2015-03-30
FR17C1011I2 (fr) 2018-04-27
UA97536C2 (en) 2012-02-27
JP5261488B2 (ja) 2013-08-14
BRPI0721905B1 (pt) 2020-11-17
KR20160040735A (ko) 2016-04-14
HK1143595A1 (en) 2011-01-07
KR101474831B1 (ko) 2014-12-19
ES2390606T3 (es) 2012-11-14
MY161991A (en) 2017-05-31
HUS1700018I1 (hu) 2017-05-29
KR20150010802A (ko) 2015-01-28
TN2010000060A1 (en) 2011-09-26
IL242292A0 (en) 2015-11-30
PH12014500053B1 (en) 2015-03-30
EP2178888B1 (en) 2012-07-04
EA028622B1 (ru) 2017-12-29
JP2010535759A (ja) 2010-11-25

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