HK1143595A1 - Proteasome inhibitors - Google Patents

Proteasome inhibitors

Info

Publication number
HK1143595A1
HK1143595A1 HK10110167.4A HK10110167A HK1143595A1 HK 1143595 A1 HK1143595 A1 HK 1143595A1 HK 10110167 A HK10110167 A HK 10110167A HK 1143595 A1 HK1143595 A1 HK 1143595A1
Authority
HK
Hong Kong
Prior art keywords
proteasome inhibitors
proteasome
inhibitors
Prior art date
Application number
HK10110167.4A
Other languages
English (en)
Inventor
Edward J Olhava
Miheala D Danca
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1143595(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of HK1143595A1 publication Critical patent/HK1143595A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK10110167.4A 2007-08-06 2010-10-28 Proteasome inhibitors HK1143595A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/017440 WO2009020448A1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors

Publications (1)

Publication Number Publication Date
HK1143595A1 true HK1143595A1 (en) 2011-01-07

Family

ID=38691782

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10110167.4A HK1143595A1 (en) 2007-08-06 2010-10-28 Proteasome inhibitors
HK13110199.3A HK1182924A1 (zh) 2007-08-06 2013-09-02 蛋白酶體抑制劑

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK13110199.3A HK1182924A1 (zh) 2007-08-06 2013-09-02 蛋白酶體抑制劑

Country Status (33)

Country Link
EP (3) EP3210987A1 (xx)
JP (1) JP5261488B2 (xx)
KR (6) KR20140042932A (xx)
CN (1) CN101772507B (xx)
AU (1) AU2007357338B2 (xx)
BR (1) BRPI0721905B8 (xx)
CA (1) CA2695082C (xx)
CY (2) CY1113386T1 (xx)
DK (1) DK2178888T3 (xx)
EA (1) EA028622B1 (xx)
EC (1) ECSP10010015A (xx)
ES (1) ES2390606T3 (xx)
FR (1) FR17C1011I2 (xx)
GE (1) GEP20125599B (xx)
HK (2) HK1143595A1 (xx)
HR (1) HRP20120745T1 (xx)
HU (1) HUS1700018I1 (xx)
IL (4) IL203641A (xx)
LT (1) LTC2178888I2 (xx)
LU (1) LUC00013I2 (xx)
MY (1) MY161991A (xx)
NL (1) NL300871I2 (xx)
NZ (1) NZ582693A (xx)
PH (1) PH12014500053B1 (xx)
PL (1) PL2178888T3 (xx)
PT (1) PT2178888E (xx)
RS (1) RS52435B (xx)
SG (1) SG10201508712QA (xx)
SI (1) SI2178888T1 (xx)
TN (1) TN2010000060A1 (xx)
UA (1) UA97536C2 (xx)
WO (1) WO2009020448A1 (xx)
ZA (1) ZA201000348B (xx)

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US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
CN105237621A (zh) 2005-11-09 2016-01-13 欧尼斯治疗公司 用于酶抑制的化合物
EP2041158B1 (en) 2006-06-19 2013-04-17 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
CL2008002966A1 (es) 2007-10-04 2010-06-25 Onyx Therapeutics Inc Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros.
MX349769B (es) 2008-06-17 2017-08-11 Millennium Pharm Inc Compuestos de éster boronato y composiciones farmacéuticas de los mismos.
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
EA035100B1 (ru) 2008-10-21 2020-04-28 Оникс Терапьютикс, Инк. Комбинированная терапия с применением пептид эпоксикетонов
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
WO2011060179A1 (en) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Use of peptide epoxyketones for metastasis suppression
CN102725300B (zh) 2009-12-22 2015-03-11 赛福伦公司 蛋白酶体抑制剂及其制备、纯化、和应用的方法
US9359398B2 (en) 2010-03-01 2016-06-07 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
EA029521B1 (ru) 2010-03-31 2018-04-30 Милленниум Фармасьютикалз, Инк. Производные 1-амино-2-циклопропилэтилбороновой кислоты
US20140121182A1 (en) * 2011-06-22 2014-05-01 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
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EP2793900B1 (en) * 2011-12-22 2018-08-22 Ares Trading S.A. Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
US20140357596A1 (en) * 2012-01-24 2014-12-04 Millennium Pharmaceuticals, Inc. Method of treatment of nasopharyngeal cancer
EP2810066B1 (en) * 2012-01-24 2019-07-31 Millennium Pharmaceuticals, Inc. Methods of treatment of cancer
UY34897A (es) 2012-07-09 2014-01-31 Onyx Therapeutics Inc Profarmacos de inhibidores peptidicos de expoxi cetona proteasa
CN103570806B (zh) * 2012-07-26 2020-04-07 圣特莱国际公司 多肽环氧酮化合物
JP2013006855A (ja) * 2012-09-03 2013-01-10 Millennium Pharmaceuticals Inc プロテアソーム阻害剤
US9464098B2 (en) * 2012-12-03 2016-10-11 Hoffmann-La Roche Inc. Substituted triazole boronic acid compounds
MX2016003979A (es) 2013-10-03 2016-06-15 Millennium Pharm Inc Metodo para profilaxis o tratamiento de lupus eritematoso sistemico y/o nefritis lupica.
JP2017524652A (ja) 2014-05-20 2017-08-31 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤
EP3808349B1 (en) 2014-08-07 2022-10-05 Mayo Foundation for Medical Education and Research Compounds and methods for treating cancer
MA41555A (fr) * 2015-02-17 2017-12-26 Millennium Pharm Inc Polythérapie pour le traitement du cancer
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (zh) * 2015-10-21 2017-05-03 北京大学 蛋白酶体抑制剂mln9708的合成方法
CN107400142B (zh) * 2016-05-19 2019-11-19 成都奥璟生物科技有限公司 一种硼酸和硼酸酯类化合物及其应用
CN106008572B (zh) * 2016-05-23 2018-08-17 成都千禧莱医药科技有限公司 一类二肽硼酸化合物及制备方法和用途
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AU2017282651B2 (en) 2016-06-21 2021-08-12 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
EP3476850A4 (en) * 2016-07-25 2019-06-19 Shenzhen Targetrx, Inc. SUBSTITUTED BORIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION THEREFOR AND APPLICATION THEREOF
CN108440583B (zh) * 2017-01-23 2020-12-04 成都奥璟生物科技有限公司 一种新的硼酸衍生物及其药物组合物
WO2018160717A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
WO2019020099A1 (zh) * 2017-07-28 2019-01-31 成都地奥九泓制药厂 一种硼酸酯化合物、其合成方法及其用途
WO2019038406A1 (en) 2017-08-25 2019-02-28 Synthon B.V. PROCESS FOR THE PREPARATION OF IXAZOMIB OR ITS INTERMEDIATES
JP2018024694A (ja) * 2017-10-03 2018-02-15 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN110903310B (zh) * 2018-09-14 2022-11-22 成都奥璟生物科技有限公司 一种硼酸酯类药物及其用途
CN110357787A (zh) * 2019-08-02 2019-10-22 苏州艾和医药科技有限公司 依沙佐米合成工艺研究
US20220362268A1 (en) * 2019-10-07 2022-11-17 Cornell University Antimicrobial and antiviral effects of c2-c7 alkyl boronic acids
CN110950897B (zh) * 2019-12-12 2021-05-28 山东大学 一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用

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Also Published As

Publication number Publication date
EP3210987A1 (en) 2017-08-30
LUC00013I1 (xx) 2017-04-06
ECSP10010015A (es) 2010-04-30
UA97536C2 (xx) 2012-02-27
PH12014500053A1 (en) 2015-03-30
CA2695082A1 (en) 2009-02-12
IL242290A (en) 2017-12-31
GEP20125599B (en) 2012-08-10
PH12014500053B1 (en) 2015-03-30
IL242290A0 (en) 2015-11-30
LUC00013I2 (xx) 2017-06-19
IL242291A (en) 2017-12-31
KR101831674B1 (ko) 2018-02-23
EP2527347A1 (en) 2012-11-28
PL2178888T3 (pl) 2012-11-30
TN2010000060A1 (en) 2011-09-26
EA028622B1 (ru) 2017-12-29
HRP20120745T1 (hr) 2012-10-31
JP5261488B2 (ja) 2013-08-14
SI2178888T1 (sl) 2012-11-30
CN101772507A (zh) 2010-07-07
CY2017016I2 (el) 2017-07-12
KR20140042933A (ko) 2014-04-07
FR17C1011I2 (fr) 2018-04-27
DK2178888T3 (da) 2012-10-01
EA201070247A1 (ru) 2010-06-30
LTC2178888I2 (lt) 2018-03-12
HUS1700018I1 (hu) 2017-05-29
IL242292A (en) 2017-12-31
AU2007357338A1 (en) 2009-02-12
ZA201000348B (en) 2011-03-30
AU2007357338B2 (en) 2014-03-20
MY161991A (en) 2017-05-31
NZ582693A (en) 2012-01-12
LTPA2017010I1 (lt) 2017-05-10
CY1113386T1 (el) 2016-06-22
IL242292A0 (en) 2015-11-30
EP2178888B1 (en) 2012-07-04
CN101772507B (zh) 2012-12-12
JP2010535759A (ja) 2010-11-25
PT2178888E (pt) 2012-10-04
BRPI0721905A2 (pt) 2014-02-25
SG10201508712QA (en) 2015-11-27
HK1182924A1 (zh) 2013-12-13
ES2390606T3 (es) 2012-11-14
KR101474831B1 (ko) 2014-12-19
EP2178888A1 (en) 2010-04-28
NL300871I2 (nl) 2017-12-07
CY2017016I1 (el) 2017-07-12
BRPI0721905B1 (pt) 2020-11-17
KR20160040735A (ko) 2016-04-14
FR17C1011I1 (xx) 2017-05-26
IL203641A (en) 2015-11-30
CA2695082C (en) 2015-07-28
KR20140042932A (ko) 2014-04-07
RS52435B (en) 2013-02-28
WO2009020448A1 (en) 2009-02-12
KR20100059811A (ko) 2010-06-04
KR20150010802A (ko) 2015-01-28
KR20170004031A (ko) 2017-01-10
IL242291A0 (en) 2015-11-30
BRPI0721905B8 (pt) 2021-05-25

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