BR112014005810A2 - formas sólidas de um inibidor da dissociação de transtirretina - Google Patents

formas sólidas de um inibidor da dissociação de transtirretina

Info

Publication number
BR112014005810A2
BR112014005810A2 BR112014005810A BR112014005810A BR112014005810A2 BR 112014005810 A2 BR112014005810 A2 BR 112014005810A2 BR 112014005810 A BR112014005810 A BR 112014005810A BR 112014005810 A BR112014005810 A BR 112014005810A BR 112014005810 A2 BR112014005810 A2 BR 112014005810A2
Authority
BR
Brazil
Prior art keywords
solid forms
transthyretin
dissociation inhibitor
relates
solid
Prior art date
Application number
BR112014005810A
Other languages
English (en)
Inventor
Henry O'neill Michael
Frederic Labaudiniere Richard
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR112014005810A2 publication Critical patent/BR112014005810A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

resumo patente de invenção: "formas sólidas de um inibidor da dissociação de transtirretina". a presente invenção refere-se a formas sólidas do sal n-metil-d-glucamina (meglumina) de 6-carbóxi-2-(3,5-diclorofenil)-benzoxazol e a métodos para sua preparação. a invenção também se refere a composições farmacêuticas contendo pelo menos uma forma sólida e ao uso terapêutico ou profilático dessas formas sólidas e composições.
BR112014005810A 2011-09-16 2012-09-12 formas sólidas de um inibidor da dissociação de transtirretina BR112014005810A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161535551P 2011-09-16 2011-09-16
PCT/IB2012/054748 WO2013038351A1 (en) 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor

Publications (1)

Publication Number Publication Date
BR112014005810A2 true BR112014005810A2 (pt) 2017-03-28

Family

ID=47116132

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014005810A BR112014005810A2 (pt) 2011-09-16 2012-09-12 formas sólidas de um inibidor da dissociação de transtirretina

Country Status (17)

Country Link
US (2) US9249112B2 (pt)
EP (1) EP2755961A1 (pt)
JP (2) JP5869677B2 (pt)
KR (1) KR20140054231A (pt)
CN (1) CN103781770B (pt)
AR (1) AR088755A1 (pt)
AU (1) AU2012310157B2 (pt)
BR (1) BR112014005810A2 (pt)
CA (1) CA2847293C (pt)
HK (1) HK1197239A1 (pt)
IL (1) IL231472A0 (pt)
MX (1) MX2014003043A (pt)
RU (1) RU2586330C2 (pt)
SG (1) SG2014013270A (pt)
TW (2) TWI476185B (pt)
WO (1) WO2013038351A1 (pt)
ZA (1) ZA201401202B (pt)

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NZ766084A (en) * 2014-09-08 2023-12-22 Pfizer Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole
CN107344927A (zh) * 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
GB2571950A (en) 2018-03-13 2019-09-18 Azad Pharma Ag New polymorph and new path to synthesize tafamidis
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US20220144787A1 (en) 2019-04-11 2022-05-12 Inke, S.A. Process for Preparing 1-deoxy-1-methylamino-D-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate
WO2020232325A1 (en) 2019-05-16 2020-11-19 Teva Pharmaceuticals International Gmbh Solid state forms of tafamidis and salts thereof
WO2021019448A1 (en) * 2019-08-01 2021-02-04 Honour (R&D) Process for the preparation of transthyretin dissociation inhibitor
WO2021093809A1 (zh) * 2019-11-15 2021-05-20 苏州科睿思制药有限公司 他发米帝司的晶型及其制备方法和用途
KR20220114626A (ko) 2019-12-20 2022-08-17 화이자 아일랜드 파마슈티컬즈 6-카르복시 벤족사졸 유도체의 효율적인 제조 방법
WO2021232619A1 (zh) * 2020-05-19 2021-11-25 苏州科睿思制药有限公司 一种他发米帝司游离酸的晶型及其制备方法和用途
WO2022009221A1 (en) * 2020-07-04 2022-01-13 Nuray Chemicals Private Limited Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
EP4083027A1 (en) 2021-04-26 2022-11-02 Química Sintética, S.A. A solid state form of tafamidis and a process for its preparation
WO2023020762A1 (en) 2021-08-16 2023-02-23 Synthon B.V. Crystalline forms of tafamidis nicotinamide adduct
WO2023091534A1 (en) 2021-11-17 2023-05-25 Teva Pharmaceuticals International Gmbh Solid state form of tafamidis

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Also Published As

Publication number Publication date
RU2586330C2 (ru) 2016-06-10
ZA201401202B (en) 2016-01-27
AU2012310157B2 (en) 2015-11-12
TW201516039A (zh) 2015-05-01
US20150031735A1 (en) 2015-01-29
IL231472A0 (en) 2014-04-30
JP2014526498A (ja) 2014-10-06
SG2014013270A (en) 2014-05-29
AU2012310157A1 (en) 2014-04-03
CA2847293C (en) 2017-03-28
MX2014003043A (es) 2015-02-05
EP2755961A1 (en) 2014-07-23
TWI476185B (zh) 2015-03-11
WO2013038351A1 (en) 2013-03-21
HK1197239A1 (zh) 2015-01-09
KR20140054231A (ko) 2014-05-08
AR088755A1 (es) 2014-07-02
CN103781770A (zh) 2014-05-07
JP2016128444A (ja) 2016-07-14
CA2847293A1 (en) 2013-03-21
NZ621194A (en) 2016-02-26
JP5869677B2 (ja) 2016-02-24
US9249112B2 (en) 2016-02-02
TWI538909B (zh) 2016-06-21
CN103781770B (zh) 2016-04-13
RU2014109676A (ru) 2015-10-27
US20160185739A1 (en) 2016-06-30
TW201315720A (zh) 2013-04-16

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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