BR112013030554A2 - forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma - Google Patents

forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma

Info

Publication number
BR112013030554A2
BR112013030554A2 BR112013030554A BR112013030554A BR112013030554A2 BR 112013030554 A2 BR112013030554 A2 BR 112013030554A2 BR 112013030554 A BR112013030554 A BR 112013030554A BR 112013030554 A BR112013030554 A BR 112013030554A BR 112013030554 A2 BR112013030554 A2 BR 112013030554A2
Authority
BR
Brazil
Prior art keywords
methods
preparation
cyclosporin
crystalline form
cyclosporine
Prior art date
Application number
BR112013030554A
Other languages
English (en)
Other versions
BR112013030554B1 (pt
Inventor
Anuradha V Gore
Ke Wu
Kiomars Karami
Richard S Graham
Scott W Smith
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46178866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013030554(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112013030554A2 publication Critical patent/BR112013030554A2/pt
Publication of BR112013030554B1 publication Critical patent/BR112013030554B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

resumo patente de invenção: "forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma". a presente invenção refere-se genericamente a formas cristalinas de ciclosporina a e particularmente a uma forma recentemente identificada de ciclosporina a. a invenção se refere ainda a métodos para sua preparação e a métodos para tratar certos distúrbios oculares.
BR112013030554-1A 2011-05-27 2012-05-25 Forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma BR112013030554B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161490887P 2011-05-27 2011-05-27
US61/490,887 2011-05-27
PCT/US2012/039611 WO2012166610A1 (en) 2011-05-27 2012-05-25 A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof

Publications (2)

Publication Number Publication Date
BR112013030554A2 true BR112013030554A2 (pt) 2016-09-06
BR112013030554B1 BR112013030554B1 (pt) 2020-12-15

Family

ID=46178866

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013030554-1A BR112013030554B1 (pt) 2011-05-27 2012-05-25 Forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma

Country Status (19)

Country Link
US (4) US8772245B2 (pt)
EP (2) EP3521302A1 (pt)
JP (1) JP6163482B2 (pt)
KR (1) KR102079402B1 (pt)
CN (1) CN103649108B (pt)
AR (1) AR086586A1 (pt)
AU (4) AU2012262513B2 (pt)
BR (1) BR112013030554B1 (pt)
CA (1) CA2836946C (pt)
CL (1) CL2013003400A1 (pt)
IL (2) IL229475A0 (pt)
MX (1) MX362271B (pt)
MY (1) MY180581A (pt)
RU (1) RU2602062C2 (pt)
SG (1) SG10201607344UA (pt)
TW (1) TWI554522B (pt)
UA (1) UA113627C2 (pt)
WO (1) WO2012166610A1 (pt)
ZA (1) ZA201308665B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014011768A2 (pt) * 2011-11-15 2017-05-09 Allergan Inc forma 2 de ciclosporina a e método de produção da mesma
AU2012339695B2 (en) * 2011-11-15 2017-10-05 Allergan, Inc. Sustained action formulation of cyclosporin Form 2
WO2013074625A1 (en) * 2011-11-15 2013-05-23 Allergan, Inc. Suspensions of cyclosporin a form 2
KR102015151B1 (ko) 2011-11-15 2019-08-27 알러간, 인코포레이티드 사이클로스포린 a 제2형의 고압멸균처리 가능한 현탁액
WO2013181339A2 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US10524661B2 (en) * 2013-06-12 2020-01-07 Proactive Live, Inc. Sleep monitoring and stimulation
AU2015289387B2 (en) 2014-07-18 2020-10-22 Allergan, Inc. Suspension compositions of cyclosporin A for subconjunctival and periocular injection
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US10443292B2 (en) * 2016-04-25 2019-10-15 Magna Closures, Inc. Non-contact obstacle detection system for motor vehicles
WO2018225961A1 (ko) * 2017-05-17 2018-12-13 주식회사 유유제약 신규한 펩타이드 및 이를 유효성분으로 포함하는 안구질환 치료용 약학 조성물
US11613558B2 (en) 2018-11-14 2023-03-28 Yuyu Pharma, Inc. Peptides and pharmaceutical compositions for treating eye diseases
WO2024085235A1 (ja) * 2022-10-20 2024-04-25 中外製薬株式会社 環状ペプチドの結晶の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
RU2009144186A (ru) 2007-05-04 2011-06-10 Аллерган, Инк. (Us) Применение циклоспоринов при лечении пациентов с интраокулярными линзами
BRPI0822221A2 (pt) * 2008-01-04 2015-06-23 Alcon Pharmaceuticals Ltd Composições aquosas e estáveis de ciclosporina

Also Published As

Publication number Publication date
BR112013030554B1 (pt) 2020-12-15
AU2012262513A1 (en) 2013-12-12
UA113627C2 (xx) 2017-02-27
KR20140047054A (ko) 2014-04-21
NZ618213A (en) 2016-05-27
EP2714720B1 (en) 2018-12-26
EP2714720A1 (en) 2014-04-09
AU2016203990A1 (en) 2016-06-30
SG10201607344UA (en) 2016-10-28
EP3521302A1 (en) 2019-08-07
TW201311730A (zh) 2013-03-16
TWI554522B (zh) 2016-10-21
AU2019204192B2 (en) 2021-02-04
AR086586A1 (es) 2014-01-08
MX2013013855A (es) 2014-02-17
WO2012166610A1 (en) 2012-12-06
AU2012262513B2 (en) 2016-03-17
CA2836946C (en) 2017-08-01
CN103649108A (zh) 2014-03-19
IL290158A (en) 2022-03-01
RU2602062C2 (ru) 2016-11-10
CL2013003400A1 (es) 2014-08-18
MY180581A (en) 2020-12-02
KR102079402B1 (ko) 2020-02-19
US20130023482A1 (en) 2013-01-24
US9206228B2 (en) 2015-12-08
ZA201308665B (en) 2014-07-30
CA2836946A1 (en) 2012-12-06
AU2019204192A1 (en) 2019-07-04
JP6163482B2 (ja) 2017-07-12
NZ719272A (en) 2017-10-27
JP2014515372A (ja) 2014-06-30
US8772245B2 (en) 2014-07-08
RU2013155033A (ru) 2015-07-20
AU2017265008A1 (en) 2017-12-07
US20210269484A1 (en) 2021-09-02
US20140315827A1 (en) 2014-10-23
US20160083432A1 (en) 2016-03-24
MX362271B (es) 2019-01-10
CN103649108B (zh) 2017-03-29
IL229475A0 (en) 2014-01-30

Similar Documents

Publication Publication Date Title
BR112013030554A2 (pt) forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma
GT201400033A (es) Pirimidinas anilladas sustituidas y uso de las mismas
EA201301240A1 (ru) Полиморфная форма бензоата линаглиптина
CO6940374A2 (es) Composiciones, usos y métodos para tratamiento de trastornos y enfermedades metabólicas
BR112014010177A2 (pt) composto, composição farmacêutica, uso do composto, e, método para a profilaxia ou tratamento de um estado ou uma condição de doença
EA201891833A1 (ru) Комбинация для лечения амиотрофического бокового склероза или родственных болезней
BR112014009866A2 (pt) formulações de anticorpos e métodos
BR112015020389A2 (pt) compostos carbazol úteis como inibidores de bromodomínio
UY34545A (es) Novedosas dihidropirimidinoisoquinolinonas y composiciones farmacéuticas de las mismas para el tratamiento de trastornos inflamatorios.
BR112014010206A2 (pt) composto, composição farmacêutica, uso de composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença
EA201391719A1 (ru) Хиназолиновые производные для лечения вирусных инфекций и дальнейших заболеваний
WO2012106393A3 (en) Withanolide isolated from physalis longifolia and analogs and methods of use thereof
PH12014501273A1 (en) Intranasal dexmedetomidine compositions and methods of use thereof
UY34467A (es) Procedimiento para la preparación de 5-fluoro-1h-pirazolopiridinas sustituidas
EA201600506A1 (ru) КРИСТАЛЛИЧЕСКИЙ КОМПЛЕКС 1-ЦИАНО-2-(4-ЦИКЛОПРОПИЛБЕНЗИЛ)-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)БЕНЗОЛА, СПОСОБЫ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЕ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ
BR112014005025A2 (pt) composição farmacêutica para uso no tratamento de uma doença neurodegenerativa
EA201600088A1 (ru) Парентеральное введение тапентадола
CO6970598A2 (es) Derivados de 4-pregenen-11ss-17-21-triol-3,20-diona para el tratamiento de afecciones oculares
MX2016003823A (es) Inhibidor selectivo de fosfatidil-inositol 3-cinasa-gamma.
EA201101241A1 (ru) Лечение лейкозов и хронических миелопролиферативных болезней антителами к ерна3
CL2012002540A1 (es) Hidrato de hidrocloruro de agomelatina; forma cristalina; metodo de preparacion; composicion farmaceutica ; y su uso para el tratamiento de trastornos del sueño, estrés, ansiedad, depresion mayor, enfermedades cardiovasculares, entre otras.
EA201490761A1 (ru) R(+)-n-формилпропаргиламиноиндан
MX370253B (es) Composiciones de compuestos de jasmonato y métodos de uso de las mismas.
BR112013022052A2 (pt) ligantes antagonísticos de dr3
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/05/2012, OBSERVADAS AS CONDICOES LEGAIS.