UY35492A - Compuestos novedosos - Google Patents

Compuestos novedosos

Info

Publication number
UY35492A
UY35492A UY0001035492A UY35492A UY35492A UY 35492 A UY35492 A UY 35492A UY 0001035492 A UY0001035492 A UY 0001035492A UY 35492 A UY35492 A UY 35492A UY 35492 A UY35492 A UY 35492A
Authority
UY
Uruguay
Prior art keywords
compounds
phenyl
new compounds
acetylamino
heteroaryl
Prior art date
Application number
UY0001035492A
Other languages
English (en)
Inventor
Dr Kai Thede
Dr Eckhard Bender
Dr Dirk Schneider
Manfred Möwes
Dr Andrea Hägebarth
Dr Philip Lienau
Dr Stefan Golz
Scott William
Dr Florian Puehler
Dr Daniel Basting
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY35492A publication Critical patent/UY35492A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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Abstract

La presente invención se relaciona con N-(fenil-heteroaril)-3-acetilamino-benzamidas sustituidas y N-[3-(acetilamino)fenil]-fenil-heteroaril-carboxamidas de fórmula general (I) como se describe y se define en la presente, con métodos de preparación de dichos compuestos, con compuestos intermediar ios útiles para preparar dichos compuestos, con c omposiciones farmacéuticas y combinaciones que comprenden dichos compuestos y con el uso de dichos compuestos para la elaboración de una composición farmacéutica para el tratamiento o profilaxis de una enfermedad.
UY0001035492A 2013-03-20 2014-03-19 Compuestos novedosos UY35492A (es)

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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2519517B1 (en) 2009-12-29 2015-03-25 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
CA2907528A1 (en) * 2013-03-20 2014-09-25 Bayer Pharma Aktiengesellschaft Novel compounds
SG11201606913PA (en) * 2014-03-20 2016-10-28 Bayer Pharma AG Inhibitors of the wnt signalling pathways
AP2016009432A0 (en) * 2014-03-20 2016-09-30 Bayer Pharma AG Novel compounds
JP2018507212A (ja) * 2015-02-20 2018-03-15 バイエル・ファルマ・アクティエンゲゼルシャフト Ｎ−フェニル−（モルホリン−４−イルまたはピペラジニル）アセトアミド誘導体およびｗｎｔシグナル伝達経路の阻害剤としてのその使用
EP3259268A1 (en) * 2015-02-20 2017-12-27 Bayer Pharma Aktiengesellschaft 1,3,4-thiadiazol-2-yl-benzamide derivatives as inhibitorsof the wnt signalling pathway
EP3259263A1 (en) * 2015-02-20 2017-12-27 Bayer Pharma Aktiengesellschaft 3-carbamoylphenyl-4-carboxamide and isophtalamide derivatives as inhibitors of the wnt signalling pathway
AU2016243529B2 (en) 2015-03-27 2021-03-25 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
JP7028766B2 (ja) * 2015-09-09 2022-03-02 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼの阻害剤
CN107033134B (zh) * 2017-05-03 2020-02-21 贵州大学 含吡啶盐和1,3,4-噁二唑基的双酰胺类化合物及其制备方法及应用
AR112840A1 (es) 2017-09-29 2019-12-18 Bayer Ag 3- fenilquinazolin-4(3h)-onas sustituidas y sus usos
WO2019063708A1 (en) 2017-09-29 2019-04-04 Bayer Aktiengesellschaft SUBSTITUTED 3-PHENYLQUINAZOLIN-4 (3H) -ONES AND USES THEREOF
CN108358864B (zh) * 2017-12-15 2020-07-17 五邑大学 一种2-酰基-5-苯基噁唑类微管蛋白抑制剂的制备方法及应用
MA54133B1 (fr) 2018-03-08 2022-01-31 Incyte Corp Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
US20220249447A1 (en) * 2019-04-26 2022-08-11 Purdue Research Foundation CF3-, OCF3-, SCF3-, and SF5-Containing Antibacterial Agents
CN112409223B (zh) * 2019-10-12 2023-01-31 中国药科大学 酰胺类化合物及其作为sting抑制剂的医药用途
CN115583938A (zh) * 2021-07-05 2023-01-10 南通聚太生物科技有限公司 靶向BCL9/β-连环蛋白互相作用的小分子化合物
WO2024022521A1 (zh) * 2022-07-28 2024-02-01 南通环聚泰生物科技有限公司 靶向BCL9/β-连环蛋白互相作用的小分子化合物
CN115850202A (zh) * 2022-12-26 2023-03-28 上海科技大学 一种卷曲受体7的小分子抑制剂及其制备方法和应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
AU6645998A (en) 1996-12-23 1998-07-17 Du Pont Pharmaceuticals Company Oxygen or sulfur containing heteroaromatics as factor xa inhibitors
NZ509318A (en) * 1998-08-04 2002-10-25 Astrazeneca Ab Amide derivatives, their preparation and use in the treatment of diseases mediated by cytokines
CZ20013276A3 (cs) 1999-03-17 2001-12-12 Astrazeneca Ab Nové amidové deriváty, způsob jejich přípravy a farmaceutická kompozice, která je obsahuje
AU2003249244A1 (en) 2002-07-15 2004-02-02 Combinatorx, Incorporated Methods for the treatment of neoplasms
WO2004022536A1 (en) 2002-09-04 2004-03-18 Glenmark Pharmaceuticals Limited New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
US7803783B2 (en) 2002-12-06 2010-09-28 The Board Of Trustees Of The Leland Stanford Junior University Use of WNT inhibitors to augment therapeutic index of chemotherapy
WO2005084368A2 (en) 2004-03-02 2005-09-15 Neurogen Corporation Heteroalkyl-substituted biphenyl-4-carboxylic acid arylamide analogues
US9052324B2 (en) 2004-05-19 2015-06-09 Enzo Biochem, Inc. Compounds and assays for controlling Wnt activity
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
WO2006063806A1 (de) * 2004-12-15 2006-06-22 Bayer Schering Pharma Aktiengesellschaft Metasubstituierte thiazolidinone, deren herstellung und verwendung als arzneimittel
ATE507205T1 (de) * 2006-12-11 2011-05-15 Genetics Co Inc Aromatische 1,4-di-carboxylamide und deren verwendung
TW200833663A (en) 2006-12-21 2008-08-16 Astrazeneca Ab Therapeutic agents
WO2010014948A1 (en) 2008-08-01 2010-02-04 The University Of Utah Research Foundation Methods of treatment using wnt inhibitors
JP2010138079A (ja) 2008-12-09 2010-06-24 Mitsui Chemicals Inc アミド誘導体および殺虫剤
PT2403499T (pt) * 2009-03-02 2019-12-19 Stemsynergy Therapeutics Inc Métodos e composições para utilização no tratamento de cancro e redução de efeitos mediados por wnt numa célula
TW201041404A (en) * 2009-03-06 2010-11-16 Sony Corp Image processing device and method
WO2011035321A1 (en) 2009-09-21 2011-03-24 Duke University Treatment of wnt/frizzled-related diseases
US20110189097A1 (en) 2009-11-09 2011-08-04 Dritan Agalliu Use of WNT inhibitor to inhibit angiogenesis in the CNS
WO2011099832A2 (en) * 2010-02-12 2011-08-18 Crystalgenomics, Inc. Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same
WO2012088712A1 (en) 2010-12-31 2012-07-05 Curegenix Inc. Compound as wnt signaling inhibitor, composition, and use thereof
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
WO2013093508A2 (en) * 2011-12-22 2013-06-27 Oslo University Hospital Hf Wnt pathway inhibitors
CA2907528A1 (en) 2013-03-20 2014-09-25 Bayer Pharma Aktiengesellschaft Novel compounds
AP2016009432A0 (en) 2014-03-20 2016-09-30 Bayer Pharma AG Novel compounds
SG11201606913PA (en) 2014-03-20 2016-10-28 Bayer Pharma AG Inhibitors of the wnt signalling pathways
EP3259263A1 (en) 2015-02-20 2017-12-27 Bayer Pharma Aktiengesellschaft 3-carbamoylphenyl-4-carboxamide and isophtalamide derivatives as inhibitors of the wnt signalling pathway
JP2018507212A (ja) 2015-02-20 2018-03-15 バイエル・ファルマ・アクティエンゲゼルシャフト Ｎ−フェニル−（モルホリン−４−イルまたはピペラジニル）アセトアミド誘導体およびｗｎｔシグナル伝達経路の阻害剤としてのその使用
EP3259268A1 (en) 2015-02-20 2017-12-27 Bayer Pharma Aktiengesellschaft 1,3,4-thiadiazol-2-yl-benzamide derivatives as inhibitorsof the wnt signalling pathway

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TW201444793A (zh) 2014-12-01
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