BR112015024073A2 - Derivados de 3-acetilamino-1-(fenil-heteroaril- aminocarbonil ou fenil-heteroarilcarbonilamino) benzeno para tratamento de doenças hiperproliferativas - Google Patents

Derivados de 3-acetilamino-1-(fenil-heteroaril- aminocarbonil ou fenil-heteroarilcarbonilamino) benzeno para tratamento de doenças hiperproliferativas

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Publication number
BR112015024073A2
BR112015024073A2 BR112015024073A BR112015024073A BR112015024073A2 BR 112015024073 A2 BR112015024073 A2 BR 112015024073A2 BR 112015024073 A BR112015024073 A BR 112015024073A BR 112015024073 A BR112015024073 A BR 112015024073A BR 112015024073 A2 BR112015024073 A2 BR 112015024073A2
Authority
BR
Brazil
Prior art keywords
phenyl
heteroaryl
treatment
compounds
hyperproliferative diseases
Prior art date
Application number
BR112015024073A
Other languages
English (en)
Inventor
Schneider Dirk
Andrea Hägebarth Dr
Anja Richter Dr
Daniel Basting Dr
Eckhard Bender Dr
Florian Puehler Dr
Kai Thede Dr
Ludwig Zorn Dr
Ningshu Liu Dr
Philip Lienau Dr
Stefan Golz Dr
William J Scott Dr
Franziska Siegel Dra
Ursula Mönning Dra
Möwes Manfred
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of BR112015024073A2 publication Critical patent/BR112015024073A2/pt

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

resumo derivados de 3-acetilamino-1-(fenil-heteroaril-aminocarbonil ou fenil-heteroarilcarbonilamino) benzeno para tratamento de doenças hiperproliferativas a presente invenção está relacionada a n-(fenil-heteroaril)-3-acetilaminobenzamidas e n-[3-(acetilamino)fenil]-fenil-heteroaril-carboxamidas substituídas da fórmula geral (i) conforme descrito e definido aqui, aos métodos de preparação dos compostos citados a fim de intermediar os compostos úteis para preparação dos compostos, às composições farmacêuticas e às combinações que consistem nos compostos citados e ao uso desses compostos para fabricação de uma composição farmacêutica para o tratamento ou a profilaxia de uma doença. 1/1
BR112015024073A 2013-03-20 2014-03-17 Derivados de 3-acetilamino-1-(fenil-heteroaril- aminocarbonil ou fenil-heteroarilcarbonilamino) benzeno para tratamento de doenças hiperproliferativas BR112015024073A2 (pt)

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PCT/EP2014/055300 WO2014147021A2 (en) 2013-03-20 2014-03-17 Novel compounds

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