BR112021024325A2 - Análogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluoro-metil)pirimidin-5-il]etil}benzamida - Google Patents
Análogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluoro-metil)pirimidin-5-il]etil}benzamidaInfo
- Publication number
- BR112021024325A2 BR112021024325A2 BR112021024325A BR112021024325A BR112021024325A2 BR 112021024325 A2 BR112021024325 A2 BR 112021024325A2 BR 112021024325 A BR112021024325 A BR 112021024325A BR 112021024325 A BR112021024325 A BR 112021024325A BR 112021024325 A2 BR112021024325 A2 BR 112021024325A2
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- compounds
- thiazol
- pyrimidin
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
análogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2- (trifluoro-metil)pirimidin-5-il]etil}benzamida. a presente invenção refere-se a compostos inibidores de p2x3 da fórmula (i): (i), em que r1 e r2 são como definidos aqui, métodos de preparação dos ditos compostos, compostos intermediários úteis para a preparação dos ditos compostos, composições farmacêuticas e combinações que compreendem os ditos compostos e o uso dos ditos compostos para manufatura das composições farmacêuticas para o tratamento ou a profilaxia de doenças, em particular de distúrbios neurogênicos, como um agente único ou em combinação com outros ingredientes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19182797.1A EP3757103A1 (en) | 2019-06-27 | 2019-06-27 | Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases |
PCT/EP2020/067828 WO2020260463A1 (en) | 2019-06-27 | 2020-06-25 | Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021024325A2 true BR112021024325A2 (pt) | 2022-01-11 |
Family
ID=67105828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021024325A BR112021024325A2 (pt) | 2019-06-27 | 2020-06-25 | Análogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluoro-metil)pirimidin-5-il]etil}benzamida |
Country Status (18)
Country | Link |
---|---|
US (1) | US20230013419A1 (pt) |
EP (2) | EP3757103A1 (pt) |
JP (1) | JP2022538270A (pt) |
KR (1) | KR20220027860A (pt) |
CN (1) | CN114026086A (pt) |
AU (1) | AU2020303269A1 (pt) |
BR (1) | BR112021024325A2 (pt) |
CA (1) | CA3145204A1 (pt) |
CL (1) | CL2021003455A1 (pt) |
CO (1) | CO2021017435A2 (pt) |
CR (1) | CR20210686A (pt) |
EC (1) | ECSP21088111A (pt) |
IL (1) | IL289161A (pt) |
JO (1) | JOP20210338A1 (pt) |
MA (1) | MA56383A (pt) |
MX (1) | MX2021015853A (pt) |
PE (1) | PE20220219A1 (pt) |
WO (1) | WO2020260463A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY36422A (es) | 2014-12-09 | 2016-06-30 | Evotec Ag | Benzamidas sustituidas con 1,3-tiazol-2-ilo |
CN114072399A (zh) * | 2020-05-25 | 2022-02-18 | 中国医药研究开发中心有限公司 | 芳甲酰胺类化合物及其制备方法和医药用途 |
WO2022063205A1 (zh) * | 2020-09-24 | 2022-03-31 | 中国医药研究开发中心有限公司 | 芳基甲酰胺类化合物及其制备方法和医药用途 |
JP2023543066A (ja) * | 2020-09-30 | 2023-10-12 | ヒューマンウェル ヘルスケア (グループ) カンパニー リミテッド | ベンザミド類化合物及びその使用 |
WO2023185931A1 (zh) * | 2022-03-29 | 2023-10-05 | 人福医药集团股份公司 | 一种p2x3抑制剂化合物及其盐、多晶型和用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8501933B2 (en) * | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
EP2091927B1 (en) * | 2006-11-09 | 2011-07-20 | F. Hoffmann-La Roche AG | Thiazole and oxazole-substituted arylamides |
CN102245586B (zh) * | 2008-12-16 | 2014-07-09 | 霍夫曼-拉罗奇有限公司 | 噻二唑取代的芳基酰胺 |
US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
UY36422A (es) * | 2014-12-09 | 2016-06-30 | Evotec Ag | Benzamidas sustituidas con 1,3-tiazol-2-ilo |
US10183937B2 (en) * | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
EA202092678A1 (ru) * | 2018-05-15 | 2021-04-12 | Байер Акциенгезельшафт | 1,3-тиазол-2-ил-замещенные бензамиды для лечения заболеваний, ассоциированных с сенситизацией нервных волокон |
SG11202011018PA (en) * | 2018-05-15 | 2020-12-30 | Bayer Ag | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
-
2019
- 2019-06-27 EP EP19182797.1A patent/EP3757103A1/en not_active Withdrawn
-
2020
- 2020-06-25 JO JOP/2021/0338A patent/JOP20210338A1/ar unknown
- 2020-06-25 JP JP2021577052A patent/JP2022538270A/ja active Pending
- 2020-06-25 EP EP20734210.6A patent/EP3990453A1/en active Pending
- 2020-06-25 PE PE2021002216A patent/PE20220219A1/es unknown
- 2020-06-25 AU AU2020303269A patent/AU2020303269A1/en active Pending
- 2020-06-25 WO PCT/EP2020/067828 patent/WO2020260463A1/en active Application Filing
- 2020-06-25 CN CN202080046297.9A patent/CN114026086A/zh active Pending
- 2020-06-25 KR KR1020217042065A patent/KR20220027860A/ko not_active Application Discontinuation
- 2020-06-25 BR BR112021024325A patent/BR112021024325A2/pt unknown
- 2020-06-25 CR CR20210686A patent/CR20210686A/es unknown
- 2020-06-25 MX MX2021015853A patent/MX2021015853A/es unknown
- 2020-06-25 MA MA056383A patent/MA56383A/fr unknown
- 2020-06-25 US US17/620,410 patent/US20230013419A1/en active Pending
- 2020-06-25 CA CA3145204A patent/CA3145204A1/en active Pending
-
2021
- 2021-12-03 EC ECSENADI202188111A patent/ECSP21088111A/es unknown
- 2021-12-20 IL IL289161A patent/IL289161A/en unknown
- 2021-12-20 CO CONC2021/0017435A patent/CO2021017435A2/es unknown
- 2021-12-23 CL CL2021003455A patent/CL2021003455A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JOP20210338A1 (ar) | 2023-01-30 |
MA56383A (fr) | 2022-05-04 |
JP2022538270A (ja) | 2022-09-01 |
EP3990453A1 (en) | 2022-05-04 |
WO2020260463A1 (en) | 2020-12-30 |
ECSP21088111A (es) | 2022-01-31 |
CN114026086A (zh) | 2022-02-08 |
IL289161A (en) | 2022-02-01 |
PE20220219A1 (es) | 2022-02-02 |
MX2021015853A (es) | 2022-02-03 |
CO2021017435A2 (es) | 2022-01-17 |
AU2020303269A1 (en) | 2022-02-03 |
CL2021003455A1 (es) | 2022-08-05 |
KR20220027860A (ko) | 2022-03-08 |
CA3145204A1 (en) | 2020-12-30 |
CR20210686A (es) | 2022-02-09 |
US20230013419A1 (en) | 2023-01-19 |
EP3757103A1 (en) | 2020-12-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112021024325A2 (pt) | Análogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluoro-metil)pirimidin-5-il]etil}benzamida | |
BR112017012327A8 (pt) | benzamidas substituídas por 1,3-tiazol-2-il. | |
BR112019008458A2 (pt) | 1,2,4-triazolonas 2,4,5-trisubstituídas. | |
BR112019009529A2 (pt) | novos derivados de quinolina | |
BR112022010112A2 (pt) | Aminoquinolonas substituídas como inibidores de dgkalfa para ativação imunológica | |
BR112015024073A2 (pt) | Derivados de 3-acetilamino-1-(fenil-heteroaril- aminocarbonil ou fenil-heteroarilcarbonilamino) benzeno para tratamento de doenças hiperproliferativas | |
BR112017002221A2 (pt) | 2-(morfolin-4-il)-1,7-naftiridinas | |
BR112015028879A8 (pt) | compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos | |
BR112017017009A2 (pt) | usos de um sequestrante de formaldeído e de uma composição farmacêutica, métodos para impedir, adiar, retardar ou diminuir a transformação de um composto e para tratar câncer, e, composição farmacêutica. | |
BR112013011634A2 (pt) | derivados de 2,3-di-hidroimidazol[1,2-c]quinazolina substituídos por aminoálcool úteis para tratar os distúrbios hiperproliferativos e as doenças associadas com a angiogênese derivados de 2,3-di-hidroimidazol[1,2-c] | |
BR112017023764A2 (pt) | derivados de ciclohexano substituído por amido | |
BR112014028841A2 (pt) | processo para preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metil-piperazin-l-il)-2-(tetra-hidro-piran-4-ilamino)-benzamida | |
BR112022019057A2 (pt) | Aminotiazóis substituídos como inibidores de dgkzeta para ativação imune | |
BR112018011777A2 (pt) | composições de fenfluramina e métodos para o preparo das mesmas | |
BR112016028876A2 (pt) | composto, composição farmacêutica, método para tratar uma doença ou condição em um ser humano, kit, e, uso de um composto, um sal, isômero ou uma mistura farmaceuticamente aceitável dos mesmos. | |
BR112014006763A2 (pt) | n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1 | |
BR112014001083A8 (pt) | composto, processo para a preparação de um composto, composição farmacêutica, método para o tratamento de doenças e uso de um composto | |
EA202090448A1 (ru) | Дигидрооксадиазиноны | |
BR112022001567A2 (pt) | Derivados de isoquinolina e seu uso para o tratamento de infecções parasitárias. | |
BR112017022757A2 (pt) | derivados do pirazol úteis como inibidores da proteína ativadora da 5-lipoxigenase (flap) | |
BR112022021748A2 (pt) | Compostos e composições para inibir a atividade de hif2a e seus métodos de uso | |
CO2021011023A2 (es) | Compuesto heterocíclico, composición farmacéutica que lo comprende, método para su preparación, y uso de estos | |
BR112021023770A2 (pt) | Compostos de derivado de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos | |
BR112019023109A2 (pt) | Composto, composição farmacêutica e método para tratar uma doença, distúrbio, síndrome ou afecção mediada por nadph oxidase em um indivíduo | |
BR112021026561A2 (pt) | Uso de uma composição farmacêutica na fabricação de um medicamento para a prevenção ou tratamento de doença hepática |