BR112019009529A2 - novos derivados de quinolina - Google Patents
novos derivados de quinolina Download PDFInfo
- Publication number
- BR112019009529A2 BR112019009529A2 BR112019009529A BR112019009529A BR112019009529A2 BR 112019009529 A2 BR112019009529 A2 BR 112019009529A2 BR 112019009529 A BR112019009529 A BR 112019009529A BR 112019009529 A BR112019009529 A BR 112019009529A BR 112019009529 A2 BR112019009529 A2 BR 112019009529A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- quinoline derivatives
- new quinoline
- preparing
- pharmaceutical compositions
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
novos derivados de quinolina. a presente invenção aborda novos compostos da fórmula geral (i): (i), em que a, r1, r2, r3, r4, r5, r6 e q são como aqui definidos, métodos para preparar os referidos compostos, compostos intermediários úteis para preparar os referidos compostos, composições farmacêuticas e combinações compreendendo os referidos compostos e o uso dos referidos compostos para fabricar composições farmacêuticas para tratamento, controle e/ou prevenção de doenças, em particular de infecções de helmintos, como um agente único ou em combinação com outros ingredientes ativos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16198550 | 2016-11-11 | ||
| PCT/EP2017/078319 WO2018087036A1 (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019009529A2 true BR112019009529A2 (pt) | 2019-07-30 |
Family
ID=57321155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019009529A BR112019009529A2 (pt) | 2016-11-11 | 2017-11-06 | novos derivados de quinolina |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10889573B2 (pt) |
| EP (1) | EP3538512B1 (pt) |
| JP (1) | JP7165129B2 (pt) |
| KR (1) | KR102595730B1 (pt) |
| CN (1) | CN109890793B (pt) |
| AU (1) | AU2017357503B2 (pt) |
| BR (1) | BR112019009529A2 (pt) |
| CA (1) | CA3043298A1 (pt) |
| CL (1) | CL2019001292A1 (pt) |
| CO (1) | CO2019004776A2 (pt) |
| DK (1) | DK3538512T3 (pt) |
| DO (1) | DOP2019000117A (pt) |
| ES (1) | ES2884073T3 (pt) |
| IL (1) | IL266407B (pt) |
| MX (1) | MX2019005569A (pt) |
| MY (1) | MY196327A (pt) |
| NZ (1) | NZ752550A (pt) |
| PH (1) | PH12019501034A1 (pt) |
| PL (1) | PL3538512T3 (pt) |
| PT (1) | PT3538512T (pt) |
| SG (1) | SG11201903059SA (pt) |
| SI (1) | SI3538512T1 (pt) |
| TW (1) | TWI821165B (pt) |
| UA (1) | UA126119C2 (pt) |
| UY (1) | UY37480A (pt) |
| WO (1) | WO2018087036A1 (pt) |
| ZA (1) | ZA201903708B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019015895A (es) | 2017-06-30 | 2020-02-07 | Bayer Animal Health Gmbh | Nuevos derivados de azaquinolina. |
| US11254661B2 (en) * | 2017-08-04 | 2022-02-22 | Bayer Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| CA3085675A1 (en) | 2017-12-15 | 2019-06-20 | Bayer Animal Health Gmbh | Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives |
| BR112020022619A2 (pt) * | 2018-05-09 | 2021-02-02 | Bayer Animal Health Gmbh | novos derivados de quinolina |
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| US20220064159A1 (en) * | 2018-12-18 | 2022-03-03 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| US20220064160A1 (en) * | 2018-12-18 | 2022-03-03 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| CN113825543A (zh) | 2019-03-19 | 2021-12-21 | 勃林格殷格翰动物保健美国公司 | 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物 |
| US20220242857A1 (en) * | 2019-06-07 | 2022-08-04 | Elanco Tiergesundheit Ag | Bicyclic derivatives for treating endoparasites |
| TW202120490A (zh) * | 2019-07-30 | 2021-06-01 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| BR112022012126A2 (pt) | 2019-12-18 | 2022-08-30 | Intervet Int Bv | Compostos antelmínticos compreendendo uma estrutura quinolínica |
| BR112022020315A2 (pt) | 2020-04-09 | 2022-12-13 | Bayer Animal Health Gmbh | Novos compostos anti-helmínticos |
| MX2022015038A (es) | 2020-05-29 | 2023-01-04 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos como anthelminticos. |
| US20240059680A1 (en) | 2020-11-18 | 2024-02-22 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| EP4259606A1 (en) | 2020-12-11 | 2023-10-18 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| AU2021395477A1 (en) | 2020-12-11 | 2023-06-22 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| AR127495A1 (es) | 2021-11-01 | 2024-01-31 | Boehringer Ingelheim Vetmedica Gmbh | Compuestos de pirrolopiridazina como antihelmínticos |
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| KR840000768A (ko) * | 1982-07-23 | 1984-02-27 | 박이은 | 무연통의 무연탄 난로 |
| DE3639877A1 (de) | 1986-11-21 | 1988-05-26 | Bayer Ag | Hetarylalkyl substituierte 5- und 6-ringheterocyclen |
| US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| GB0213715D0 (en) | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
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| GB0414438D0 (en) | 2004-06-28 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
| RU2394819C2 (ru) | 2004-10-20 | 2010-07-20 | Кумиай Кемикал Индастри Ко., Лтд. | Инсектицид, акарицид и нематоцид, содержащие в качестве активного компонента производное 3-триазолилфенилсульфида |
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2017
- 2017-11-06 BR BR112019009529A patent/BR112019009529A2/pt active Search and Examination
- 2017-11-06 PT PT177914389T patent/PT3538512T/pt unknown
- 2017-11-06 MX MX2019005569A patent/MX2019005569A/es unknown
- 2017-11-06 DK DK17791438.9T patent/DK3538512T3/da active
- 2017-11-06 PL PL17791438T patent/PL3538512T3/pl unknown
- 2017-11-06 SI SI201730854T patent/SI3538512T1/sl unknown
- 2017-11-06 EP EP17791438.9A patent/EP3538512B1/en active Active
- 2017-11-06 KR KR1020197013186A patent/KR102595730B1/ko active IP Right Grant
- 2017-11-06 MY MYPI2019002590A patent/MY196327A/en unknown
- 2017-11-06 NZ NZ752550A patent/NZ752550A/en unknown
- 2017-11-06 ES ES17791438T patent/ES2884073T3/es active Active
- 2017-11-06 US US16/348,797 patent/US10889573B2/en active Active
- 2017-11-06 JP JP2019524276A patent/JP7165129B2/ja active Active
- 2017-11-06 WO PCT/EP2017/078319 patent/WO2018087036A1/en unknown
- 2017-11-06 AU AU2017357503A patent/AU2017357503B2/en active Active
- 2017-11-06 CA CA3043298A patent/CA3043298A1/en active Pending
- 2017-11-06 UA UAA201906455A patent/UA126119C2/uk unknown
- 2017-11-06 SG SG11201903059SA patent/SG11201903059SA/en unknown
- 2017-11-06 CN CN201780069050.7A patent/CN109890793B/zh active Active
- 2017-11-10 UY UY0001037480A patent/UY37480A/es not_active Application Discontinuation
- 2017-11-10 TW TW106138957A patent/TWI821165B/zh active
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2019
- 2019-05-02 IL IL266407A patent/IL266407B/en unknown
- 2019-05-09 PH PH12019501034A patent/PH12019501034A1/en unknown
- 2019-05-10 CL CL2019001292A patent/CL2019001292A1/es unknown
- 2019-05-10 DO DO2019000117A patent/DOP2019000117A/es unknown
- 2019-05-10 CO CONC2019/0004776A patent/CO2019004776A2/es unknown
- 2019-06-10 ZA ZA2019/03708A patent/ZA201903708B/en unknown
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2020
- 2020-10-30 US US17/085,880 patent/US11505545B2/en active Active
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