PL3538512T3 - Nowe pochodne chinolino-3-karboksyamidu o działaniu przeciw robakom pasożytniczym - Google Patents

Nowe pochodne chinolino-3-karboksyamidu o działaniu przeciw robakom pasożytniczym

Info

Publication number
PL3538512T3
PL3538512T3 PL17791438T PL17791438T PL3538512T3 PL 3538512 T3 PL3538512 T3 PL 3538512T3 PL 17791438 T PL17791438 T PL 17791438T PL 17791438 T PL17791438 T PL 17791438T PL 3538512 T3 PL3538512 T3 PL 3538512T3
Authority
PL
Poland
Prior art keywords
quinoline
carboxamide derivatives
new anthelmintic
anthelmintic
new
Prior art date
Application number
PL17791438T
Other languages
English (en)
Inventor
Walter Hübsch
Johannes KÖBBERLING
Adeline KÖHLER
Hans-Georg Schwarz
Daniel Kulke
Claudia WELZ
Thomas Ilg
Kirsten BÖRNGEN
Wei Zhuang
Nils Griebenow
Claudia BÖHM
Niels Lindner
Maike HINK
Ulrich Görgens
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of PL3538512T3 publication Critical patent/PL3538512T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PL17791438T 2016-11-11 2017-11-06 Nowe pochodne chinolino-3-karboksyamidu o działaniu przeciw robakom pasożytniczym PL3538512T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198550 2016-11-11
EP17791438.9A EP3538512B1 (en) 2016-11-11 2017-11-06 New anthelmintic quinoline-3-carboxamide derivatives
PCT/EP2017/078319 WO2018087036A1 (en) 2016-11-11 2017-11-06 New anthelmintic quinoline-3-carboxamide derivatives

Publications (1)

Publication Number Publication Date
PL3538512T3 true PL3538512T3 (pl) 2021-11-22

Family

ID=57321155

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17791438T PL3538512T3 (pl) 2016-11-11 2017-11-06 Nowe pochodne chinolino-3-karboksyamidu o działaniu przeciw robakom pasożytniczym

Country Status (26)

Country Link
US (2) US10889573B2 (pl)
EP (1) EP3538512B1 (pl)
JP (1) JP7165129B2 (pl)
KR (1) KR102595730B1 (pl)
CN (1) CN109890793B (pl)
AU (1) AU2017357503B2 (pl)
CA (1) CA3043298A1 (pl)
CL (1) CL2019001292A1 (pl)
CO (1) CO2019004776A2 (pl)
DK (1) DK3538512T3 (pl)
DO (1) DOP2019000117A (pl)
ES (1) ES2884073T3 (pl)
IL (1) IL266407B (pl)
MX (1) MX2019005569A (pl)
MY (1) MY196327A (pl)
NZ (1) NZ752550A (pl)
PH (1) PH12019501034A1 (pl)
PL (1) PL3538512T3 (pl)
PT (1) PT3538512T (pl)
SG (1) SG11201903059SA (pl)
SI (1) SI3538512T1 (pl)
TW (1) TWI821165B (pl)
UA (1) UA126119C2 (pl)
UY (1) UY37480A (pl)
WO (1) WO2018087036A1 (pl)
ZA (1) ZA201903708B (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3068350A1 (en) 2017-06-30 2019-01-03 Bayer Animal Health Gmbh New azaquinoline derivatives
US11254661B2 (en) * 2017-08-04 2022-02-22 Bayer Animal Health Gmbh Quinoline derivatives for treating infections with helminths
EP3692037A1 (en) * 2017-12-15 2020-08-12 Bayer Animal Health GmbH Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives
SG11202010024UA (en) * 2018-05-09 2020-11-27 Bayer Animal Health Gmbh New quinoline derivatives
WO2020014068A1 (en) 2018-07-09 2020-01-16 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic heterocyclic compounds
EP3643711A1 (en) * 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
PL3897842T3 (pl) * 2018-12-18 2025-05-19 Elanco Tiergesundheit Ag Pochodne bicykliczne
NZ777370A (en) * 2018-12-18 2024-11-29 Elanco Tiergesundheit Ag Bicyclic derivatives
CA3133100A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
US12448391B2 (en) 2019-06-07 2025-10-21 Elanco Tiergesundheit Ag Bicyclic derivatives for treating endoparasites
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
WO2021122906A1 (en) 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising azaindoles structure
CA3164098A1 (en) * 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
WO2021204930A1 (en) 2020-04-09 2021-10-14 Bayer Animal Health Gmbh Substituted condensed azines as anthelmintic compounds
AU2021278889A1 (en) 2020-05-29 2023-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelmintic heterocyclic compounds
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
JP2023553269A (ja) 2020-11-18 2023-12-21 エランコ・ティアゲゾンタイト・アーゲー イヌ糸状虫感染症を治療するためのn-(2,3-ジヒドロ-1,4-ベンゾオキサジン-4-イル)-3-イソプロピル-7-(2,3,5-トリフルオロフェニル)ベンゾ-チオフェン-2-カルボキサミド誘導体及び類似化合物
TW202237600A (zh) * 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
US20240043446A1 (en) 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a thienopyridine structure
US20240043385A1 (en) 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a pyridine structure
EP4148052A1 (en) 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
UY39995A (es) 2021-11-01 2023-05-15 Boehringer Ingelheim Vetmedica GmbH Compuestos de pirrolopiridazina como antihelmínticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
WO2025027117A1 (en) 2023-08-02 2025-02-06 Intervet International B.V. Carboxamide-4-quinoline compounds with anthelmintic activity

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
KR840000768A (ko) * 1982-07-23 1984-02-27 박이은 무연통의 무연탄 난로
DE3639877A1 (de) 1986-11-21 1988-05-26 Bayer Ag Hetarylalkyl substituierte 5- und 6-ringheterocyclen
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
WO2006043635A1 (ja) 2004-10-20 2006-04-27 Kumiai Chemical Industry Co., Ltd. 3-トリアゾリルフェニルスルフィド誘導体及びそれを有効成分として含有する殺虫・殺ダニ・殺線虫剤
CA2603345C (en) * 2005-04-01 2017-05-02 Insa Rouen New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
WO2007040280A1 (ja) 2005-10-06 2007-04-12 Nippon Soda Co., Ltd. 環状アミン化合物および有害生物防除剤
JP2008214323A (ja) 2007-03-08 2008-09-18 Kyowa Hakko Kogyo Co Ltd 皮膚疾患の治療及び/または予防剤
MX2009013205A (es) 2007-06-08 2010-04-09 Helicon Therapeutics Inc Derivados de pirazoloquinolina urea terapeuticos.
JP5268461B2 (ja) 2008-07-14 2013-08-21 Meiji Seikaファルマ株式会社 Pf1364物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
MX2011005795A (es) 2008-12-12 2011-06-20 Syngenta Participations Ag N-oxipiperidinas espiroheterociclicas como pesticidas.
CN102574817A (zh) * 2009-09-24 2012-07-11 巴斯夫欧洲公司 用于抵抗无脊椎动物害虫的氨基喹唑啉化合物
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
KR20130080485A (ko) 2010-05-31 2013-07-12 신젠타 파티서페이션즈 아게 작물 강화 방법
MX363956B (es) 2010-08-31 2019-04-09 Meiji Seika Pharma Co Ltd Star Agente de control de plagas.
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
AU2013252946A1 (en) 2012-04-27 2014-12-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
KR20140094026A (ko) * 2011-11-28 2014-07-29 이 아이 듀폰 디 네모아 앤드 캄파니 N-(4-퀴놀리닐메틸) 설폰아미드 유도체 및 구충제로서의 이의 용도
WO2013096151A1 (en) 2011-12-22 2013-06-27 Glaxosmithkline Llc Chemical compounds
TWI566701B (zh) 2012-02-01 2017-01-21 日本農藥股份有限公司 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法
AR089939A1 (es) 2012-02-09 2014-10-01 Glenmark Pharmaceuticals Sa COMPUESTOS BICICLICOS COMO INHIBIDORES DE mPGES-1
ES2626360T3 (es) 2012-03-30 2017-07-24 Basf Se Compuestos de piridinilideno tiocarbonilo N-sustituidos y su uso para combatir plagas de animales
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
JP2016508972A (ja) * 2012-12-20 2016-03-24 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺ダニ剤及び殺虫剤としてのアリールスルフィド誘導体及びアリールスルホキシド誘導体
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
US20140275503A1 (en) 2013-03-13 2014-09-18 Dow Agrosciences Llc Process for the preparation of certain triaryl rhamnose carbamates
ES2686742T3 (es) 2013-05-23 2018-10-19 Syngenta Participations Ag Formulaciones de mezcla de tanque
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
EP3057429A4 (en) 2013-10-17 2017-08-09 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
WO2015058028A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
AR098475A1 (es) * 2013-11-26 2016-06-01 Bayer Cropscience Ag Compuestos pesticidas y usos
JP6377245B2 (ja) * 2014-03-24 2018-08-22 グアンドン ジョンシェン ファーマシューティカル カンパニー リミテッド Smo阻害剤としてのキノリン誘導体
TW201613866A (en) 2014-07-07 2016-04-16 Bayer Cropscience Ag Process for preparing fluorinated iminopyridine compounds
CA2975982C (en) 2015-02-17 2018-11-27 Nippon Soda Co., Ltd. Agrochemical composition
CA3008358A1 (en) 2015-12-17 2017-06-22 Astex Therapeutics Limited Quinoline-3-carboxamides as h-pgds inhibitors

Also Published As

Publication number Publication date
CL2019001292A1 (es) 2019-09-27
BR112019009529A2 (pt) 2019-07-30
US20200024264A1 (en) 2020-01-23
MY196327A (en) 2023-03-24
IL266407B (en) 2021-10-31
SG11201903059SA (en) 2019-05-30
PT3538512T (pt) 2021-08-16
AU2017357503A1 (en) 2019-05-02
NZ752550A (en) 2023-03-31
CO2019004776A2 (es) 2019-07-31
EP3538512A1 (en) 2019-09-18
RU2019117917A3 (pl) 2021-03-05
ES2884073T3 (es) 2021-12-10
JP2019535706A (ja) 2019-12-12
JP7165129B2 (ja) 2022-11-02
WO2018087036A1 (en) 2018-05-17
CN109890793A (zh) 2019-06-14
US11505545B2 (en) 2022-11-22
US20210115026A1 (en) 2021-04-22
DK3538512T3 (da) 2021-07-05
PH12019501034A1 (en) 2019-12-02
AU2017357503B2 (en) 2022-02-17
KR102595730B1 (ko) 2023-10-27
ZA201903708B (en) 2022-11-30
UA126119C2 (uk) 2022-08-17
SI3538512T1 (sl) 2021-09-30
CN109890793B (zh) 2022-11-18
MX2019005569A (es) 2019-09-05
US10889573B2 (en) 2021-01-12
DOP2019000117A (es) 2019-05-31
TWI821165B (zh) 2023-11-11
KR20190076980A (ko) 2019-07-02
RU2019117917A (ru) 2020-12-11
TW201829384A (zh) 2018-08-16
IL266407A (en) 2019-06-30
EP3538512B1 (en) 2021-06-16
UY37480A (es) 2018-06-29
CA3043298A1 (en) 2018-05-17

Similar Documents

Publication Publication Date Title
ZA201903708B (en) New anthelmintic quinoline-3-carboxamide derivatives
ZA201800826B (en) Substituted oxopyridine derivatives
IL254870A0 (en) Quinoxaline histories are transmuted
IL253381A0 (en) History of h9-pyrrolo-dipyridine
PL3790874T3 (pl) Nowe pochodne chinoliny o działaniu przeciw robakom pasożytniczym
SG11201805869XA (en) Quinolin-2-one derivatives
SG11201609205WA (en) Heterocyclyl-butanamide derivatives
PL3418273T3 (pl) Pochodne flawaglin
HUE050450T2 (hu) Fluoralkil-fluorén-származékok
IL248773A0 (en) History of naphthyridinedione
IL261201B (en) Aminobenzaimidazole derivatives
IL251005B (en) Pyrido-oxazinone derivatives
IL248629A0 (en) Substances containing diheteroaryl conjugated to cycloalkyl and their uses
HUE044703T2 (hu) Új CYP-eikozanoid származékok
PL3119744T3 (pl) Pochodne 2-cyjano-3-cyklopropylo-3-hydroksy-N-arylo-tioakryloamidu
HUP1600234A2 (en) Mdr-reversing 8-hydroxy-quinoline derivatives
GB201416351D0 (en) Heterocyclic derivatives
PT3319956T (pt) Derivados de oxopiridina substituída
TH1601000368A (th) อนุพันธ์ควินอลีน