UY37480A - Nuevos derivados de quinolina - Google Patents

Nuevos derivados de quinolina

Info

Publication number
UY37480A
UY37480A UY0001037480A UY37480A UY37480A UY 37480 A UY37480 A UY 37480A UY 0001037480 A UY0001037480 A UY 0001037480A UY 37480 A UY37480 A UY 37480A UY 37480 A UY37480 A UY 37480A
Authority
UY
Uruguay
Prior art keywords
compounds
preparation
quinolina
new derivatives
pharmaceutical compositions
Prior art date
Application number
UY0001037480A
Other languages
English (en)
Inventor
Claudia Welz Dra
Kirsten Börngen Dra
Daniel Kulke Dr
Dr Thomas Ilg Prof
Walter Hübsch Dr
Hans-Georg Schwarz Dr
Niels Lindner
Johannes Köbberling Dr
Adeline Köhler Dra
Wei Zhuang Dr
Claudia Böhm Dra
Maike Hink Dr
Görgens Ulrich
Nils Griebenow Dr
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of UY37480A publication Critical patent/UY37480A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La invención abarca nuevos compuestos de quinolina de la fórmula general (I): en la cual A, R1, R2, R3, R4, R5, R6 y Q son como se definen en el presente, procedimientos para la elaboración de dichos compuestos, compuestos intermedios útiles para la elaboración de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la elaboración de composiciones farmacéuticas para el tratamiento, control y/o prevención de enfermedades, en particular de infecciones con helmintos, como un único agente o en combinación con otros principios activos.
UY0001037480A 2016-11-11 2017-11-10 Nuevos derivados de quinolina UY37480A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16198550 2016-11-11

Publications (1)

Publication Number Publication Date
UY37480A true UY37480A (es) 2018-06-29

Family

ID=57321155

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037480A UY37480A (es) 2016-11-11 2017-11-10 Nuevos derivados de quinolina

Country Status (26)

Country Link
US (2) US10889573B2 (es)
EP (1) EP3538512B1 (es)
JP (1) JP7165129B2 (es)
KR (1) KR102595730B1 (es)
CN (1) CN109890793B (es)
AU (1) AU2017357503B2 (es)
CA (1) CA3043298A1 (es)
CL (1) CL2019001292A1 (es)
CO (1) CO2019004776A2 (es)
DK (1) DK3538512T3 (es)
DO (1) DOP2019000117A (es)
ES (1) ES2884073T3 (es)
IL (1) IL266407B (es)
MX (1) MX2019005569A (es)
MY (1) MY196327A (es)
NZ (1) NZ752550A (es)
PH (1) PH12019501034A1 (es)
PL (1) PL3538512T3 (es)
PT (1) PT3538512T (es)
SG (1) SG11201903059SA (es)
SI (1) SI3538512T1 (es)
TW (1) TWI821165B (es)
UA (1) UA126119C2 (es)
UY (1) UY37480A (es)
WO (1) WO2018087036A1 (es)
ZA (1) ZA201903708B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA125800C2 (uk) 2017-06-30 2022-06-08 Баєр Енімал Хелс Гмбх Похідні азахіноліну
ES3024942T3 (en) * 2017-08-04 2025-06-05 Elanco Animal Health Gmbh Quinoline derivatives for treating infections with helminths
SG11202004260YA (en) 2017-12-15 2020-06-29 Bayer Animal Health Gmbh Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives
CA3099610A1 (en) 2018-05-09 2019-11-14 Bayer Animal Health Gmbh New quinoline derivatives
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
EP3643711A1 (en) 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
PL3897842T3 (pl) * 2018-12-18 2025-05-19 Elanco Tiergesundheit Ag Pochodne bicykliczne
US20220064160A1 (en) * 2018-12-18 2022-03-03 Elanco Tiergesundheit Ag Bicyclic derivatives
BR112021018631A2 (pt) 2019-03-19 2021-11-23 Boehringer Ingelheim Animal Health Usa Inc Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano
CN114206860B (zh) * 2019-06-07 2025-02-18 礼蓝动物保健有限公司 用于治疗体内寄生虫的双环衍生物
TWI865563B (zh) 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
MX2022007671A (es) 2019-12-18 2022-07-19 Intervet Int Bv Compuestos antihelminticos que comprenden una estructura de azaindoles.
WO2021122911A1 (en) 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising a quinoline structure
BR112022020315A2 (pt) 2020-04-09 2022-12-13 Bayer Animal Health Gmbh Novos compostos anti-helmínticos
WO2021242581A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
WO2022106469A2 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
AU2021398540A1 (en) 2020-12-11 2023-06-22 Intervet International B.V. Anthelmintic compounds comprising a pyridine structure
AU2021395477A1 (en) 2020-12-11 2023-06-22 Intervet International B.V. Anthelmintic compounds comprising a thienopyridine structure
EP4148052A1 (en) 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
UY39995A (es) 2021-11-01 2023-05-15 Boehringer Ingelheim Vetmedica GmbH Compuestos de pirrolopiridazina como antihelmínticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
CN121620507A (zh) 2023-08-02 2026-03-06 英特维特国际股份有限公司 具有驱虫活性的甲酰胺-4-喹啉化合物

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
KR840000768A (ko) * 1982-07-23 1984-02-27 박이은 무연통의 무연탄 난로
DE3639877A1 (de) 1986-11-21 1988-05-26 Bayer Ag Hetarylalkyl substituierte 5- und 6-ringheterocyclen
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
RU2394819C2 (ru) 2004-10-20 2010-07-20 Кумиай Кемикал Индастри Ко., Лтд. Инсектицид, акарицид и нематоцид, содержащие в качестве активного компонента производное 3-триазолилфенилсульфида
AU2006228683B2 (en) * 2005-04-01 2012-02-02 Vfp Therapies New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-Alzheimer agents
BRPI0616667B1 (pt) 2005-10-06 2017-07-18 Nippon Soda Co. , Ltd. Compounds of cyclical amine or salts thereof or non-oxides thereof, and agents for control of fever
JP2008214323A (ja) 2007-03-08 2008-09-18 Kyowa Hakko Kogyo Co Ltd 皮膚疾患の治療及び／または予防剤
AU2008261888A1 (en) 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline urea derivatives
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
US9067892B2 (en) 2008-12-12 2015-06-30 Syngenta Crop Protection, Inc. Spiroheterocyclic N-oxypiperidines as pesticides
US8796180B2 (en) * 2009-09-24 2014-08-05 Basf Se Aminoquinazoline compounds for combating invertebrate pests
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
JP2013527208A (ja) 2010-05-31 2013-06-27 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 作物を増強する方法
PE20131380A1 (es) 2010-08-31 2014-01-05 Meiji Seika Pharma Co Ltd Agente de control de plagas
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
CN103958476A (zh) * 2011-11-28 2014-07-30 纳幕尔杜邦公司 N-(4-喹啉基甲基)磺酰胺衍生物以及它们作为驱肠虫剂的用途
WO2013096151A1 (en) 2011-12-22 2013-06-27 Glaxosmithkline Llc Chemical compounds
TWI566701B (zh) 2012-02-01 2017-01-21 日本農藥股份有限公司 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法
WO2013118071A1 (en) 2012-02-09 2013-08-15 Glenmark Pharmaceuticals S.A. BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS
US9334238B2 (en) 2012-03-30 2016-05-10 Basf Se N-substituted pyridinylidenes for combating animal pests
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
NZ700595A (en) 2012-04-27 2016-04-29 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
JP2016508972A (ja) * 2012-12-20 2016-03-24 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺ダニ剤及び殺虫剤としてのアリールスルフィド誘導体及びアリールスルホキシド誘導体
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
US20140275503A1 (en) 2013-03-13 2014-09-18 Dow Agrosciences Llc Process for the preparation of certain triaryl rhamnose carbamates
WO2014187846A1 (en) 2013-05-23 2014-11-27 Syngenta Participations Ag Tank-mix formulations
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
MX2016004942A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
CA2925873A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
AR098475A1 (es) * 2013-11-26 2016-06-01 Bayer Cropscience Ag Compuestos pesticidas y usos
JP6377245B2 (ja) 2014-03-24 2018-08-22 グアンドン ジョンシェン ファーマシューティカル カンパニー リミテッド Ｓｍｏ阻害剤としてのキノリン誘導体
TW201613866A (en) 2014-07-07 2016-04-16 Bayer Cropscience Ag Process for preparing fluorinated iminopyridine compounds
CN107205396B (zh) 2015-02-17 2019-08-30 日本曹达株式会社 农药组合物
CN108430992A (zh) 2015-12-17 2018-08-21 阿斯特克斯医疗公司 作为h-pgds抑制剂的喹啉-3-甲酰胺

Also Published As

Publication number Publication date
TW201829384A (zh) 2018-08-16
JP2019535706A (ja) 2019-12-12
WO2018087036A1 (en) 2018-05-17
DOP2019000117A (es) 2019-05-31
CO2019004776A2 (es) 2019-07-31
MX2019005569A (es) 2019-09-05
RU2019117917A3 (es) 2021-03-05
EP3538512A1 (en) 2019-09-18
US20210115026A1 (en) 2021-04-22
SG11201903059SA (en) 2019-05-30
EP3538512B1 (en) 2021-06-16
UA126119C2 (uk) 2022-08-17
ZA201903708B (en) 2022-11-30
RU2019117917A (ru) 2020-12-11
TWI821165B (zh) 2023-11-11
US10889573B2 (en) 2021-01-12
SI3538512T1 (sl) 2021-09-30
BR112019009529A2 (pt) 2019-07-30
CN109890793B (zh) 2022-11-18
PL3538512T3 (pl) 2021-11-22
KR20190076980A (ko) 2019-07-02
JP7165129B2 (ja) 2022-11-02
KR102595730B1 (ko) 2023-10-27
IL266407A (en) 2019-06-30
US20200024264A1 (en) 2020-01-23
AU2017357503A1 (en) 2019-05-02
US11505545B2 (en) 2022-11-22
CL2019001292A1 (es) 2019-09-27
DK3538512T3 (da) 2021-07-05
CN109890793A (zh) 2019-06-14
AU2017357503B2 (en) 2022-02-17
NZ752550A (en) 2023-03-31
PT3538512T (pt) 2021-08-16
IL266407B (en) 2021-10-31
PH12019501034A1 (en) 2019-12-02
CA3043298A1 (en) 2018-05-17
ES2884073T3 (es) 2021-12-10
MY196327A (en) 2023-03-24

Similar Documents

Publication Publication Date Title
DOP2019000117A (es) Nuevos derivados de quinolina
DOP2020000023A (es) Nuevos derivados de quinolina
CO2019014484A2 (es) Nuevos derivados de azaquinolina
CL2020002891A1 (es) Nuevos derivados de quinolina
CO2018010966A2 (es) Nuevos derivados de pirazolopirimidina
ECSP19030002A (es) 1,2,4-triazolonas 2,4,5-trisustituidas
DOP2019000275A (es) Nuevos derivados de pirazol bicíclicos
UY37460A (es) 1,2,4-triazolonas con anelación en 4 y 5
CO2020001242A2 (es) Dihidrooxadiazinonas
UY38816A (es) Nuevos derivados de isoquinolina
UY37971A (es) Derivados de indol macrocíclicos sustituidos
DOP2020000100A (es) Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3
UY37250A (es) Derivados macrocíclicos de indol
UY37973A (es) Derivados de indol macrocíclicos
UY37972A (es) Derivados de indol macrocíclicos sustituidos con cloro
UY37032A (es) Compuestos de heteroarilbenzimidazol

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20230705