CO2020001244A2 - Derivados de quinolina para tratar infecciones con helmintos - Google Patents
Derivados de quinolina para tratar infecciones con helmintosInfo
- Publication number
- CO2020001244A2 CO2020001244A2 CONC2020/0001244A CO2020001244A CO2020001244A2 CO 2020001244 A2 CO2020001244 A2 CO 2020001244A2 CO 2020001244 A CO2020001244 A CO 2020001244A CO 2020001244 A2 CO2020001244 A2 CO 2020001244A2
- Authority
- CO
- Colombia
- Prior art keywords
- compounds
- quinoline derivatives
- helminth infections
- treat
- preparation
- Prior art date
Links
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
- 208000006968 Helminthiasis Diseases 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 244000000013 helminth Species 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
La invención abarca nuevos compuestos de quinolina de la fórmula general (I): (I), en la cual A, R1, R2, R3, R4, R5, R6 y Q son como se definen en el presente, procedimientos para la elaboración de dichos compuestos, compuestos intermedios útiles para la elaboración de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la elaboración de composiciones farmacéuticas para el tratamiento, control y/o prevención de enfermedades, en particular de infecciones con helmintos, como un único agente o en combinación con otros principios activos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17185001 | 2017-08-04 | ||
| PCT/EP2018/070552 WO2019025341A1 (en) | 2017-08-04 | 2018-07-30 | QUINOLINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS BY HELMINTHES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2020001244A2 true CO2020001244A2 (es) | 2020-02-18 |
Family
ID=59558299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2020/0001244A CO2020001244A2 (es) | 2017-08-04 | 2020-02-04 | Derivados de quinolina para tratar infecciones con helmintos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11254661B2 (es) |
| EP (1) | EP3634959A1 (es) |
| JP (1) | JP7455294B2 (es) |
| KR (1) | KR20200036909A (es) |
| CN (1) | CN111132977A (es) |
| AU (1) | AU2018311019B2 (es) |
| BR (1) | BR112020002348A2 (es) |
| CA (1) | CA3071759A1 (es) |
| CL (1) | CL2020000301A1 (es) |
| CO (1) | CO2020001244A2 (es) |
| DO (1) | DOP2020000023A (es) |
| IL (1) | IL272156B2 (es) |
| MX (1) | MX2020001403A (es) |
| PH (1) | PH12020500257A1 (es) |
| SG (1) | SG11202000266VA (es) |
| TW (1) | TWI790263B (es) |
| UY (1) | UY37831A (es) |
| WO (1) | WO2019025341A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| JP7324846B2 (ja) * | 2018-12-18 | 2023-08-10 | エランコ・ティアゲゾンタイト・アーゲー | 二環式誘導体 |
| WO2020131629A1 (en) | 2018-12-18 | 2020-06-25 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| CR20210477A (es) | 2019-03-19 | 2022-01-06 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de aza-benzotiofeno y aza-benzofurano como antihelmínticos |
| US20200385398A1 (en) | 2019-06-07 | 2020-12-10 | Elanco Tiergesundheit Ag | New bicyclic derivatives |
| TW202120490A (zh) * | 2019-07-30 | 2021-06-01 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| MX2022007670A (es) | 2019-12-18 | 2022-07-19 | Intervet Int Bv | Compuestos antihelminticos que comprenden una estructura de quinolina. |
| BR112022024156A2 (pt) | 2020-05-29 | 2023-02-14 | Boehringer Ingelheim Animal Health Usa Inc | Compostos heterocílicos antelmínticos |
| AU2021384833A1 (en) | 2020-11-18 | 2023-06-15 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| AU2021395477A1 (en) | 2020-12-11 | 2023-06-22 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| WO2022122987A1 (en) | 2020-12-11 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| EP4148052A1 (en) * | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| CA3236894A1 (en) | 2021-11-01 | 2023-05-04 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic pyrrolopyridazine compounds |
| WO2023183437A1 (en) * | 2022-03-22 | 2023-09-28 | Sporos Biodiscovery, Inc. | Tead inhibitors and methods of use |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3639877A1 (de) | 1986-11-21 | 1988-05-26 | Bayer Ag | Hetarylalkyl substituierte 5- und 6-ringheterocyclen |
| US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| GB0213715D0 (en) | 2002-06-14 | 2002-07-24 | Syngenta Ltd | Chemical compounds |
| TWI312272B (en) | 2003-05-12 | 2009-07-21 | Sumitomo Chemical Co | Pyrimidine compound and pests controlling composition containing the same |
| GB0414438D0 (en) | 2004-06-28 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
| EP1803712B1 (en) | 2004-10-20 | 2015-12-30 | Kumiai Chemical Industry Co., Ltd. | 3-triazolylphenyl sulfide derivative and insecticide/acaricide/nematicide containing the same as active ingredient |
| BRPI0606869A2 (pt) * | 2005-01-28 | 2009-07-21 | Janssen Pharmaceutica Nv | derivados anti-helmìnticos de imidazol-tiazol |
| PL1947098T3 (pl) | 2005-10-06 | 2012-03-30 | Nippon Soda Co | Cykliczne związki aminowe i środek do zwalczania szkodników |
| JP2008214323A (ja) | 2007-03-08 | 2008-09-18 | Kyowa Hakko Kogyo Co Ltd | 皮膚疾患の治療及び／または予防剤 |
| JP5268461B2 (ja) | 2008-07-14 | 2013-08-21 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤 |
| CN101337937B (zh) | 2008-08-12 | 2010-12-22 | 国家农药创制工程技术研究中心 | 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物 |
| CN101337940B (zh) | 2008-08-12 | 2012-05-02 | 国家农药创制工程技术研究中心 | 具杀虫活性的含氮杂环二氯烯丙醚类化合物 |
| CN101715774A (zh) | 2008-10-09 | 2010-06-02 | 浙江化工科技集团有限公司 | 一个具有杀虫活性化合物制备及用途 |
| EP2184273A1 (de) | 2008-11-05 | 2010-05-12 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
| GB0820344D0 (en) | 2008-11-06 | 2008-12-17 | Syngenta Ltd | Herbicidal compositions |
| AP2653A (en) | 2008-12-12 | 2013-04-25 | Syngenta Participations Ag | Spiroheterocyclic N-oxypiperidines as pesticides |
| JP2012513464A (ja) * | 2008-12-23 | 2012-06-14 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | ホスホジエステラーゼ阻害剤及びその使用 |
| WO2011085575A1 (zh) | 2010-01-15 | 2011-07-21 | 江苏省农药研究所股份有限公司 | 邻杂环甲酰苯胺类化合物及其合成方法和应用 |
| AR081721A1 (es) | 2010-02-25 | 2012-10-17 | Nippon Soda Co | Compuesto de amina ciclica y acaricida |
| BR112012030408A2 (pt) | 2010-05-31 | 2015-09-29 | Syngenta Participations Ag | método de melhoramento de culturas |
| ES2693089T3 (es) * | 2010-08-31 | 2018-12-07 | Meiji Seika Pharma Co., Ltd. | Agente de control de plagas |
| CN101967139B (zh) | 2010-09-14 | 2013-06-05 | 中化蓝天集团有限公司 | 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用 |
| US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| US9392301B2 (en) * | 2011-07-01 | 2016-07-12 | Qualcomm Incorporated | Context adaptive entropy coding for non-square blocks in video coding |
| WO2013050317A1 (en) | 2011-10-03 | 2013-04-11 | Syngenta Limited | Polymorphs of an isoxazoline derivative |
| CN102391261A (zh) | 2011-10-14 | 2012-03-28 | 上海交通大学 | 一种n-取代噁二嗪类化合物及其制备方法和应用 |
| AU2012331285A1 (en) | 2011-11-02 | 2014-04-17 | Bayer Intellectual Property Gmbh | Compounds with nematicidal activity |
| TWI566701B (zh) | 2012-02-01 | 2017-01-21 | 日本農藥股份有限公司 | 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法 |
| AR089939A1 (es) | 2012-02-09 | 2014-10-01 | Glenmark Pharmaceuticals Sa | COMPUESTOS BICICLICOS COMO INHIBIDORES DE mPGES-1 |
| MX2014011829A (es) | 2012-03-30 | 2015-03-19 | Basf Se | Compuestos de piridinilideno n-sustituidos y derivados para combatir plagas de animales. |
| EP2647626A1 (en) | 2012-04-03 | 2013-10-09 | Syngenta Participations AG. | 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| RU2623233C2 (ru) | 2012-04-27 | 2017-06-23 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидные композиции и относящиеся к ним способы |
| CN103109816B (zh) | 2013-01-25 | 2014-09-10 | 青岛科技大学 | 硫代苯甲酰胺类化合物及其应用 |
| CN103232431B (zh) | 2013-01-25 | 2014-11-05 | 青岛科技大学 | 一种二卤代吡唑酰胺类化合物及其应用 |
| WO2014158644A1 (en) | 2013-03-13 | 2014-10-02 | Dow Agrosciences Llc | Process for the preparation of triaryl rhamnose carbamates |
| ES2686742T3 (es) | 2013-05-23 | 2018-10-19 | Syngenta Participations Ag | Formulaciones de mezcla de tanque |
| CN103265527B (zh) | 2013-06-07 | 2014-08-13 | 江苏省农用激素工程技术研究中心有限公司 | 邻氨基苯甲酰胺化合物及其制备方法和应用 |
| CN103524422B (zh) | 2013-10-11 | 2015-05-27 | 中国农业科学院植物保护研究所 | 苯并咪唑衍生物及其制备方法和用途 |
| CN105636441B (zh) | 2013-10-17 | 2018-06-15 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| KR20160072155A (ko) | 2013-10-17 | 2016-06-22 | 다우 아그로사이언시즈 엘엘씨 | 살충성 화합물의 제조 방법 |
| AR098475A1 (es) * | 2013-11-26 | 2016-06-01 | Bayer Cropscience Ag | Compuestos pesticidas y usos |
| WO2016005276A1 (en) | 2014-07-07 | 2016-01-14 | Bayer Cropscience Aktiengesellschaft | Process for preparing fluorinated iminopyridine compounds |
| UY36196A (es) * | 2014-07-25 | 2016-02-29 | Bayer Animal Health Gmbh | Compuestos para usar en el tratamiento antihelmíntico |
| CN107205396B (zh) | 2015-02-17 | 2019-08-30 | 日本曹达株式会社 | 农药组合物 |
| KR20180095580A (ko) | 2015-12-17 | 2018-08-27 | 아스텍스 테라퓨틱스 리미티드 | H-pgds 억제제로서의 퀴놀린-3-카르복스아미드 |
| KR102595730B1 (ko) * | 2016-11-11 | 2023-10-27 | 바이엘 애니멀 헬스 게엠베하 | 새로운 구충 퀴놀린-3-카르복스아미드 유도체 |
-
2018
- 2018-07-30 WO PCT/EP2018/070552 patent/WO2019025341A1/en unknown
- 2018-07-30 IL IL272156A patent/IL272156B2/en unknown
- 2018-07-30 EP EP18745626.4A patent/EP3634959A1/en active Pending
- 2018-07-30 JP JP2020505351A patent/JP7455294B2/ja active Active
- 2018-07-30 CN CN201880064509.9A patent/CN111132977A/zh active Pending
- 2018-07-30 KR KR1020207005873A patent/KR20200036909A/ko not_active Application Discontinuation
- 2018-07-30 MX MX2020001403A patent/MX2020001403A/es unknown
- 2018-07-30 BR BR112020002348-5A patent/BR112020002348A2/pt unknown
- 2018-07-30 CA CA3071759A patent/CA3071759A1/en active Pending
- 2018-07-30 AU AU2018311019A patent/AU2018311019B2/en active Active
- 2018-07-30 US US16/636,276 patent/US11254661B2/en active Active
- 2018-07-30 SG SG11202000266VA patent/SG11202000266VA/en unknown
- 2018-08-02 TW TW107126871A patent/TWI790263B/zh active
- 2018-08-03 UY UY0001037831A patent/UY37831A/es not_active Application Discontinuation
-
2020
- 2020-02-03 CL CL2020000301A patent/CL2020000301A1/es unknown
- 2020-02-04 CO CONC2020/0001244A patent/CO2020001244A2/es unknown
- 2020-02-04 DO DO2020000023A patent/DOP2020000023A/es unknown
- 2020-02-04 PH PH12020500257A patent/PH12020500257A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN111132977A (zh) | 2020-05-08 |
| JP7455294B2 (ja) | 2024-03-26 |
| SG11202000266VA (en) | 2020-02-27 |
| US11254661B2 (en) | 2022-02-22 |
| EP3634959A1 (en) | 2020-04-15 |
| RU2020109388A3 (es) | 2021-11-30 |
| JP2020528921A (ja) | 2020-10-01 |
| IL272156B2 (en) | 2023-09-01 |
| IL272156A (en) | 2020-03-31 |
| MX2020001403A (es) | 2020-03-09 |
| TW201920155A (zh) | 2019-06-01 |
| AU2018311019B2 (en) | 2022-05-26 |
| BR112020002348A2 (pt) | 2020-09-08 |
| CA3071759A1 (en) | 2019-02-07 |
| UY37831A (es) | 2019-02-28 |
| KR20200036909A (ko) | 2020-04-07 |
| AU2018311019A1 (en) | 2020-01-30 |
| RU2020109388A (ru) | 2021-09-07 |
| CL2020000301A1 (es) | 2020-07-31 |
| PH12020500257A1 (en) | 2020-09-14 |
| DOP2020000023A (es) | 2020-02-28 |
| TWI790263B (zh) | 2023-01-21 |
| WO2019025341A1 (en) | 2019-02-07 |
| US20200377486A1 (en) | 2020-12-03 |
| IL272156B1 (en) | 2023-05-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2020001244A2 (es) | Derivados de quinolina para tratar infecciones con helmintos | |
| DOP2019000117A (es) | Nuevos derivados de quinolina | |
| ECSP19030002A (es) | 1,2,4-triazolonas 2,4,5-trisustituidas | |
| DOP2018000226A (es) | Nuevos derivados de pirazolopirimidina | |
| CO2019014484A2 (es) | Nuevos derivados de azaquinolina | |
| CO2020013876A2 (es) | Nuevos derivados de quinolina | |
| UY37460A (es) | 1,2,4-triazolonas con anelación en 4 y 5 | |
| CO2021005226A2 (es) | Nuevos compuestos antihelmínticos | |
| CO2019011877A2 (es) | Nuevos derivados de pirazol bicíclicos | |
| CO2020001242A2 (es) | Dihidrooxadiazinonas | |
| UY37971A (es) | Derivados de indol macrocíclicos sustituidos | |
| UY37250A (es) | Derivados macrocíclicos de indol | |
| UY37972A (es) | Derivados de indol macrocíclicos sustituidos con cloro | |
| UY37973A (es) | Derivados de indol macrocíclicos | |
| UY38816A (es) | Nuevos derivados de isoquinolina | |
| DOP2020000100A (es) | Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3 | |
| UY36983A (es) | Pirazolopiridinaminas sustituidas | |
| UY37032A (es) | Compuestos de heteroarilbenzimidazol |