BR112015001169A2 - polimorfo, uso do polimorfo, composição farmacêutica e uso para preparar o polimorfo - Google Patents
polimorfo, uso do polimorfo, composição farmacêutica e uso para preparar o polimorfoInfo
- Publication number
- BR112015001169A2 BR112015001169A2 BR112015001169A BR112015001169A BR112015001169A2 BR 112015001169 A2 BR112015001169 A2 BR 112015001169A2 BR 112015001169 A BR112015001169 A BR 112015001169A BR 112015001169 A BR112015001169 A BR 112015001169A BR 112015001169 A2 BR112015001169 A2 BR 112015001169A2
- Authority
- BR
- Brazil
- Prior art keywords
- polymorph
- preparing
- pharmaceutical composition
- pharmaceutical
- composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210249796.5 | 2012-07-18 | ||
| CN201210249796.5A CN103570613B (zh) | 2012-07-18 | 2012-07-18 | 氘代ω-二苯基脲或其盐的多晶型物 |
| PCT/CN2013/079469 WO2014012480A1 (zh) | 2012-07-18 | 2013-07-16 | 氘代ω-二苯基脲或其盐的多晶型物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015001169A2 true BR112015001169A2 (pt) | 2017-06-27 |
| BR112015001169B1 BR112015001169B1 (pt) | 2021-04-13 |
Family
ID=49948285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015001169-1A BR112015001169B1 (pt) | 2012-07-18 | 2013-07-16 | Polimorfo e composição farmacêutica |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9573900B2 (pt) |
| JP (1) | JP6072908B2 (pt) |
| KR (3) | KR20150034790A (pt) |
| CN (1) | CN103570613B (pt) |
| BR (1) | BR112015001169B1 (pt) |
| RU (1) | RU2600929C2 (pt) |
| WO (1) | WO2014012480A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105348186B (zh) * | 2015-10-15 | 2018-05-22 | 青岛海洋生物医药研究院股份有限公司 | 氘代双芳基脲类化合物及其制备方法和在制备抗肿瘤的药物中的应用 |
| CN111956646B (zh) | 2016-03-02 | 2023-07-25 | 麦迪维尔股份公司 | 索拉非尼或瑞戈非尼与曲沙他滨的氨基磷酸酯前药的组合治疗 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE556713T1 (de) * | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
| NZ553804A (en) * | 2004-09-29 | 2010-07-30 | Bayer Schering Pharma Ag | Thermodynamically stable form of bay 43-9006 tosylate |
| US20090069388A1 (en) * | 2007-09-11 | 2009-03-12 | Protia, Llc | Deuterium-enriched sorafenib |
| US8217061B2 (en) * | 2008-01-17 | 2012-07-10 | Sicor Inc. | Polymorphs of sorafenib tosylate and sorafenib hemi-tosylate, and processes for preparation thereof |
| CN101671299A (zh) * | 2008-09-10 | 2010-03-17 | 上海朴颐化学科技有限公司 | 索拉非尼的合成方法 |
| CN101676266B (zh) * | 2008-09-19 | 2011-10-26 | 苏州泽璟生物制药有限公司 | 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物 |
| WO2010079498A2 (en) * | 2009-01-12 | 2010-07-15 | Hetero Research Foundation | Novel polymorph of sorafenib tosylate |
| EP2440531A2 (en) * | 2009-06-12 | 2012-04-18 | Ratiopharm GmbH | Polymorphs of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methyl-pyridine-2-carboxamide |
| WO2011076711A2 (en) * | 2009-12-23 | 2011-06-30 | Ratiopharm Gmbh | Polymorphs of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide |
| US20130012548A1 (en) * | 2010-03-18 | 2013-01-10 | Suzhou Zelgen Biopharmaceutical Co., Ltd. | Deuterium-substituted omega-diphenylurea and derivatives thereof and pharmaceutical compositions comprising the compounds |
| CN102190616B (zh) * | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | 一种氘代的ω-二苯基脲的合成及生产的方法和工艺 |
| EP2548859B1 (en) * | 2010-03-18 | 2015-03-04 | Suzhou Zelgen Biopharmaceutical Co., Ltd. | Preparation methods of methyl-d3-amine and salts thereof |
| WO2012071425A1 (en) * | 2010-11-22 | 2012-05-31 | Teva Pharmaceutical Industries Ltd. | Solid state forms of sorafenib besylate, and processes for preparations thereof |
| US20150175545A1 (en) * | 2012-09-18 | 2015-06-25 | Suzhou Zelgen Biopharmaceutical Co., Ltd | Preparation Method of Fluoro-Substituted Deuterated Diphenylurea |
-
2012
- 2012-07-18 CN CN201210249796.5A patent/CN103570613B/zh active Active
-
2013
- 2013-07-16 JP JP2015521962A patent/JP6072908B2/ja active Active
- 2013-07-16 KR KR1020157004252A patent/KR20150034790A/ko active Application Filing
- 2013-07-16 RU RU2015105109/04A patent/RU2600929C2/ru active
- 2013-07-16 WO PCT/CN2013/079469 patent/WO2014012480A1/zh active Application Filing
- 2013-07-16 US US14/415,340 patent/US9573900B2/en active Active - Reinstated
- 2013-07-16 KR KR1020177006890A patent/KR20170031799A/ko active Application Filing
- 2013-07-16 KR KR1020197010740A patent/KR20190042748A/ko not_active Application Discontinuation
- 2013-07-16 BR BR112015001169-1A patent/BR112015001169B1/pt active IP Right Grant
-
2017
- 2017-01-25 US US15/414,813 patent/US9889123B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015522591A (ja) | 2015-08-06 |
| JP6072908B2 (ja) | 2017-02-01 |
| CN103570613B (zh) | 2016-06-15 |
| RU2600929C2 (ru) | 2016-10-27 |
| RU2015105109A (ru) | 2016-09-10 |
| WO2014012480A1 (zh) | 2014-01-23 |
| CN103570613A (zh) | 2014-02-12 |
| KR20170031799A (ko) | 2017-03-21 |
| BR112015001169B1 (pt) | 2021-04-13 |
| US20170128427A1 (en) | 2017-05-11 |
| KR20190042748A (ko) | 2019-04-24 |
| US20150266823A1 (en) | 2015-09-24 |
| US9573900B2 (en) | 2017-02-21 |
| US9889123B2 (en) | 2018-02-13 |
| KR20150034790A (ko) | 2015-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/07/2013, OBSERVADAS AS CONDICOES LEGAIS. |