ATE548375T1 - Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung - Google Patents
Exemestan und zwischenprodukte davon und verfahren zu dessen herstellungInfo
- Publication number
- ATE548375T1 ATE548375T1 AT05711473T AT05711473T ATE548375T1 AT E548375 T1 ATE548375 T1 AT E548375T1 AT 05711473 T AT05711473 T AT 05711473T AT 05711473 T AT05711473 T AT 05711473T AT E548375 T1 ATE548375 T1 AT E548375T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- exemestane
- compound
- production
- intermediate products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53694404P | 2004-01-16 | 2004-01-16 | |
PCT/US2005/001248 WO2005070951A1 (en) | 2004-01-16 | 2005-01-14 | Exemestane and its intermediates and methods of making the same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE548375T1 true ATE548375T1 (de) | 2012-03-15 |
Family
ID=34807064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05711473T ATE548375T1 (de) | 2004-01-16 | 2005-01-14 | Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung |
Country Status (6)
Country | Link |
---|---|
US (2) | US8183401B2 (de) |
EP (1) | EP1709062B9 (de) |
AT (1) | ATE548375T1 (de) |
ES (1) | ES2382609T3 (de) |
HK (1) | HK1096973A1 (de) |
WO (1) | WO2005070951A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8183401B2 (en) | 2004-01-16 | 2012-05-22 | Cedarburg Pharmaceuticals, Inc. | Exemestane and its intermediates and methods of making the same |
JP5255444B2 (ja) * | 2005-09-30 | 2013-08-07 | エンディース エルエルシー | (s)−6−メチルオキサアルキルエキセメスタン化合物および関連する使用方法 |
US8168621B2 (en) | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
US10174070B2 (en) | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
WO2008067450A2 (en) * | 2006-11-30 | 2008-06-05 | Endece, Llc | 6-alkoxyalkyl estradiol derivatives and methods of use |
US20080275259A1 (en) * | 2007-05-04 | 2008-11-06 | Scinopharm Taiwan, Ltd | Process for preparing aromatase inhibitors |
NZ581667A (en) | 2007-06-25 | 2012-03-30 | Scinopharm Taiwan Ltd | Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin |
AU2008269075A1 (en) * | 2007-06-25 | 2008-12-31 | Scinopharm Taiwan, Ltd. | Crystalline polymorph of exemestane |
SG188396A1 (en) | 2010-09-14 | 2013-04-30 | Endece Llc | 6-substituted demethyl-estradiol derivatives as er-beta agonists |
CN105085599A (zh) * | 2014-05-16 | 2015-11-25 | 绍兴文理学院 | 一种依西美坦中间体17,17-乙二氧基-6-亚甲基雄甾-1,4-二烯-3-酮及其制备方法和应用 |
CN106243179B (zh) * | 2016-07-31 | 2018-09-11 | 南京臣功制药股份有限公司 | 一种依西美坦工业化生产方法 |
CA3073836A1 (en) | 2017-09-11 | 2019-03-14 | Atossa Therapeutics, Inc. | Methods for making and using endoxifen |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2805231A (en) * | 1956-06-06 | 1957-09-03 | Searle & Co | 1-hydroxy-4-androstene-3, 17-dione and esters thereof |
US3850911A (en) * | 1960-09-22 | 1974-11-26 | G Hughes | Steroid synthesis |
NL122154C (de) * | 1963-10-18 | |||
US3404150A (en) * | 1966-05-25 | 1968-10-01 | Syntex Corp | Process for the esterification of hydroxy steroids |
US3634469A (en) * | 1968-10-16 | 1972-01-11 | Searle & Co | Methylenated steroids and process |
US4474701A (en) * | 1983-03-10 | 1984-10-02 | Veb Jenapharm Jena | Process for the separation of 4-androsten-3,17-dione and 1,4-androstadien-3,17-dione |
SE8303031D0 (sv) * | 1983-05-30 | 1983-05-30 | Leo Ab | Improved steroid esters preparation |
GB8517360D0 (en) * | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
DD258820A1 (de) | 1986-06-13 | 1988-08-03 | Adw Ddr | Verfahren zur herstellung von 6beta-hydroxy-methyl-androsta-1,4-dien-3,17-dion |
GB8617107D0 (en) * | 1986-07-14 | 1986-08-20 | Erba Farmitalia | 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives |
GB8622330D0 (en) * | 1986-09-17 | 1986-10-22 | Erba Farmitalia | 4-substituted 6-alkylidenandrostene-3,17-dione derivatives |
DE3714965A1 (de) * | 1987-04-30 | 1988-11-10 | Schering Ag | 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
GB8721383D0 (en) * | 1987-09-11 | 1987-10-21 | Erba Farmitalia | Preparation of methylene derivatives |
DD264220A1 (de) * | 1987-09-23 | 1989-01-25 | Adw Ddr | Verfahren zur herstellung von 6-methylen-androsta-1,4-dien-3,17-dion |
GB8801697D0 (en) * | 1988-01-26 | 1988-02-24 | Erba Farmitalia | Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione |
US5227375A (en) * | 1990-02-08 | 1993-07-13 | Endorecherche, Inc. | Aromatase inhibitors |
US8183401B2 (en) | 2004-01-16 | 2012-05-22 | Cedarburg Pharmaceuticals, Inc. | Exemestane and its intermediates and methods of making the same |
JP5255444B2 (ja) * | 2005-09-30 | 2013-08-07 | エンディース エルエルシー | (s)−6−メチルオキサアルキルエキセメスタン化合物および関連する使用方法 |
US20080275259A1 (en) * | 2007-05-04 | 2008-11-06 | Scinopharm Taiwan, Ltd | Process for preparing aromatase inhibitors |
-
2005
- 2005-01-14 US US10/586,237 patent/US8183401B2/en active Active
- 2005-01-14 ES ES05711473T patent/ES2382609T3/es active Active
- 2005-01-14 AT AT05711473T patent/ATE548375T1/de active
- 2005-01-14 EP EP05711473A patent/EP1709062B9/de active Active
- 2005-01-14 WO PCT/US2005/001248 patent/WO2005070951A1/en active Application Filing
-
2007
- 2007-04-10 HK HK07103721.3A patent/HK1096973A1/xx not_active IP Right Cessation
-
2012
- 2012-04-19 US US13/451,034 patent/US8541609B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8183401B2 (en) | 2012-05-22 |
EP1709062A4 (de) | 2010-05-26 |
US20080234505A1 (en) | 2008-09-25 |
EP1709062B1 (de) | 2012-03-07 |
EP1709062A1 (de) | 2006-10-11 |
US8541609B2 (en) | 2013-09-24 |
US20120209016A1 (en) | 2012-08-16 |
EP1709062B9 (de) | 2013-02-13 |
ES2382609T3 (es) | 2012-06-11 |
HK1096973A1 (en) | 2007-06-15 |
WO2005070951A1 (en) | 2005-08-04 |
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