DE3884555D1 - Octahydronaphthalenoxim-derivate fuer cholesterolsynthese-inhibierung, verfahren fuer deren herstellung und diese enthaltende zusammenstellungen. - Google Patents
Octahydronaphthalenoxim-derivate fuer cholesterolsynthese-inhibierung, verfahren fuer deren herstellung und diese enthaltende zusammenstellungen.Info
- Publication number
- DE3884555D1 DE3884555D1 DE88310026T DE3884555T DE3884555D1 DE 3884555 D1 DE3884555 D1 DE 3884555D1 DE 88310026 T DE88310026 T DE 88310026T DE 3884555 T DE3884555 T DE 3884555T DE 3884555 D1 DE3884555 D1 DE 3884555D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- octahydronaphthalenoxime
- inhibitation
- derivatives
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/52—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27151287 | 1987-10-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3884555D1 true DE3884555D1 (de) | 1993-11-04 |
| DE3884555T2 DE3884555T2 (de) | 1994-04-21 |
Family
ID=17501103
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE198888310026T Pending DE314435T1 (de) | 1987-10-27 | 1988-10-25 | Octahydronaphthalenoxim-derivate fuer cholesterolsynthese-inhibierung, verfahren fuer deren herstellung und diese enthaltende zusammenstellungen. |
| DE88310026T Expired - Fee Related DE3884555T2 (de) | 1987-10-27 | 1988-10-25 | Octahydronaphthalenoxim-Derivate für Cholesterolsynthese-Inhibierung, Verfahren für deren Herstellung und diese enthaltende Zusammenstellungen. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE198888310026T Pending DE314435T1 (de) | 1987-10-27 | 1988-10-25 | Octahydronaphthalenoxim-derivate fuer cholesterolsynthese-inhibierung, verfahren fuer deren herstellung und diese enthaltende zusammenstellungen. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US4997848A (de) |
| EP (1) | EP0314435B1 (de) |
| KR (1) | KR950001633B1 (de) |
| AT (1) | ATE95178T1 (de) |
| AU (1) | AU605925B2 (de) |
| CA (1) | CA1336598C (de) |
| DE (2) | DE314435T1 (de) |
| DK (1) | DK599388A (de) |
| ES (1) | ES2011427T3 (de) |
| FI (1) | FI91960C (de) |
| GR (1) | GR890300123T1 (de) |
| HK (1) | HK1005734A1 (de) |
| IE (1) | IE63960B1 (de) |
| ZA (1) | ZA888008B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| US5280032A (en) * | 1989-02-14 | 1994-01-18 | Toyama Chemical Co., Ltd. | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same |
| ZA933359B (en) | 1992-05-15 | 1993-12-08 | Sankyo Co | Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use |
| NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| IL108432A (en) * | 1993-01-29 | 1997-09-30 | Sankyo Co | DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| SI20070A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
| US6677341B2 (en) | 1999-09-23 | 2004-01-13 | Pharmacia Corporation | (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
| US8227434B1 (en) | 2003-11-04 | 2012-07-24 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Materials and methods for treating oncological disorders |
| US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
| US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| KR101686301B1 (ko) * | 2014-11-10 | 2016-12-28 | 동부대우전자 주식회사 | 세탁기용 터브의 제조장치 및 제조방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (de) * | 1974-06-07 | 1981-03-18 | ||
| JPS5840476B2 (ja) | 1975-05-12 | 1983-09-06 | 三共株式会社 | 新生理活性物質ｍｌ−２３６ｃおよびその製造法 |
| JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンｋおよびその製造法 |
| JPS55139396A (en) | 1979-04-13 | 1980-10-31 | Akira Endo | Monacolin j, new type of physiologically actice substance, and its preparation |
| JPS5651992A (en) | 1979-10-03 | 1981-05-09 | Sankyo Co Ltd | Preparation of physiologically active substance ml-236b |
| AU548996B2 (en) | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Ｍｂ−５３０ａ誘導体 |
| JPS56142236A (en) * | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
| JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| JPS5783290A (en) | 1980-11-13 | 1982-05-25 | Sankyo Co Ltd | Preparation of ml-236a and its derivative |
| JPS57155995A (en) | 1981-03-20 | 1982-09-27 | Sankyo Co Ltd | Preparation of ml-236b derivative |
| JPS5810572A (ja) | 1981-07-07 | 1983-01-21 | Sankyo Co Ltd | Ｍｌ−２３６ｂ誘導体およびその製造法 |
| JPS5855443A (ja) * | 1981-09-25 | 1983-04-01 | Sankyo Co Ltd | オクタヒドロナフタリン誘導体およびその製造法 |
| JPS5889191A (ja) | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| JPS59175450A (ja) | 1983-03-24 | 1984-10-04 | Sankyo Co Ltd | Ｍｌ−２３６ｂ誘導体 |
| JPS6113699A (ja) | 1984-06-28 | 1986-01-21 | 三菱電機株式会社 | 電気機器のシ−ルド |
| EP0215665B1 (de) | 1985-09-13 | 1991-11-21 | Sankyo Company Limited | Hydroxy-ML-236B-Derivate, deren Herstellung und Anwendung |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
-
1988
- 1988-10-21 US US07/261,739 patent/US4997848A/en not_active Expired - Lifetime
- 1988-10-25 ES ES88310026T patent/ES2011427T3/es not_active Expired - Lifetime
- 1988-10-25 DE DE198888310026T patent/DE314435T1/de active Pending
- 1988-10-25 AT AT88310026T patent/ATE95178T1/de not_active IP Right Cessation
- 1988-10-25 DE DE88310026T patent/DE3884555T2/de not_active Expired - Fee Related
- 1988-10-25 EP EP88310026A patent/EP0314435B1/de not_active Expired - Lifetime
- 1988-10-26 ZA ZA888008A patent/ZA888008B/xx unknown
- 1988-10-27 KR KR1019880014031A patent/KR950001633B1/ko not_active IP Right Cessation
- 1988-10-27 FI FI884968A patent/FI91960C/fi not_active IP Right Cessation
- 1988-10-27 CA CA000581504A patent/CA1336598C/en not_active Expired - Fee Related
- 1988-10-27 AU AU24397/88A patent/AU605925B2/en not_active Ceased
- 1988-10-27 IE IE325188A patent/IE63960B1/en unknown
- 1988-10-27 DK DK599388A patent/DK599388A/da not_active Application Discontinuation
-
1990
- 1990-01-31 GR GR89300123T patent/GR890300123T1/el unknown
- 1990-12-14 US US07/627,691 patent/US5403860A/en not_active Expired - Fee Related
-
1995
- 1995-03-07 US US08/399,500 patent/US5658942A/en not_active Expired - Fee Related
-
1998
- 1998-06-03 HK HK98104836A patent/HK1005734A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0314435B1 (de) | 1993-09-29 |
| DE3884555T2 (de) | 1994-04-21 |
| KR890006578A (ko) | 1989-06-14 |
| IE883251L (en) | 1989-04-27 |
| FI884968A0 (fi) | 1988-10-27 |
| HK1005734A1 (en) | 1999-01-22 |
| EP0314435A2 (de) | 1989-05-03 |
| ES2011427A4 (es) | 1990-01-16 |
| KR950001633B1 (ko) | 1995-02-27 |
| ZA888008B (en) | 1990-07-25 |
| ES2011427T3 (es) | 1994-11-16 |
| FI91960C (fi) | 1994-09-12 |
| US5403860A (en) | 1995-04-04 |
| DE314435T1 (de) | 1989-10-05 |
| AU605925B2 (en) | 1991-01-24 |
| IE63960B1 (en) | 1995-06-28 |
| EP0314435A3 (en) | 1990-05-16 |
| FI91960B (fi) | 1994-05-31 |
| GR890300123T1 (en) | 1990-01-31 |
| DK599388D0 (da) | 1988-10-27 |
| DK599388A (da) | 1989-04-28 |
| AU2439788A (en) | 1989-05-04 |
| US4997848A (en) | 1991-03-05 |
| ATE95178T1 (de) | 1993-10-15 |
| US5658942A (en) | 1997-08-19 |
| CA1336598C (en) | 1995-08-08 |
| FI884968A (fi) | 1989-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |