JPS55139396A - Monacolin j, new type of physiologically actice substance, and its preparation - Google Patents
Monacolin j, new type of physiologically actice substance, and its preparationInfo
- Publication number
- JPS55139396A JPS55139396A JP4424979A JP4424979A JPS55139396A JP S55139396 A JPS55139396 A JP S55139396A JP 4424979 A JP4424979 A JP 4424979A JP 4424979 A JP4424979 A JP 4424979A JP S55139396 A JPS55139396 A JP S55139396A
- Authority
- JP
- Japan
- Prior art keywords
- monacolin
- preparation
- physiologically
- substance
- actice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Monacolin J, a physiologically active substance of the formula with following physical and chemical properties: elementary analysis, C: 71.54%, H: 8.65%, 0: 19.90%; molecular weight (measured by mass analysis), 320; molecular formula, C19H28O4; sobubility, soluble in methanol, acetone, chloroform, benzen, insoluble in hexane, petroleum ether; a neutral white powder; it can be detected as a spot by thin layer chromatography.
USE: Antihyperlipemia and antiarteriosclerotic.
PREPARATION: A bacteria capable of producing monacolin J, e.g., Monascus ruber No.1005 (FERM-P No.4822) is aerobically cultured at 20W35°C.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4424979A JPS55139396A (en) | 1979-04-13 | 1979-04-13 | Monacolin j, new type of physiologically actice substance, and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4424979A JPS55139396A (en) | 1979-04-13 | 1979-04-13 | Monacolin j, new type of physiologically actice substance, and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55139396A true JPS55139396A (en) | 1980-10-31 |
JPS6113798B2 JPS6113798B2 (en) | 1986-04-15 |
Family
ID=12686252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4424979A Granted JPS55139396A (en) | 1979-04-13 | 1979-04-13 | Monacolin j, new type of physiologically actice substance, and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55139396A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0314435A2 (en) | 1987-10-27 | 1989-05-03 | Sankyo Company Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition, processes for their preparation and compositions containing them |
EP0486153A2 (en) * | 1990-10-15 | 1992-05-20 | Merck & Co. Inc. | Enzymatic hydrolysis of lovastatin acid using an enzyme derived from Clonostachys compactiuscula |
WO2010043748A1 (en) | 2008-10-15 | 2010-04-22 | Neuron Biopharma, S.A. | Biosynthesis of derivatives of monacolin j |
-
1979
- 1979-04-13 JP JP4424979A patent/JPS55139396A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0314435A2 (en) | 1987-10-27 | 1989-05-03 | Sankyo Company Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition, processes for their preparation and compositions containing them |
EP0486153A2 (en) * | 1990-10-15 | 1992-05-20 | Merck & Co. Inc. | Enzymatic hydrolysis of lovastatin acid using an enzyme derived from Clonostachys compactiuscula |
WO2010043748A1 (en) | 2008-10-15 | 2010-04-22 | Neuron Biopharma, S.A. | Biosynthesis of derivatives of monacolin j |
ES2343049A1 (en) * | 2008-10-15 | 2010-07-21 | Neuron Biopharma, S.A. | Biosynthesis of derivatives of monacolin j |
EP2380571A1 (en) * | 2008-10-15 | 2011-10-26 | Neuron Biopharma, S.A. | Biosynthesis of derivatives of monacolin j |
EP2380571A4 (en) * | 2008-10-15 | 2012-07-11 | Neuron Biopharma Sa | Biosynthesis of derivatives of monacolin j |
Also Published As
Publication number | Publication date |
---|---|
JPS6113798B2 (en) | 1986-04-15 |
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