MX9708322A - Derivados de azacicloalcano, su preparacion y sus aplicaciones en terapia. - Google Patents

Derivados de azacicloalcano, su preparacion y sus aplicaciones en terapia.

Info

Publication number
MX9708322A
MX9708322A MX9708322A MX9708322A MX9708322A MX 9708322 A MX9708322 A MX 9708322A MX 9708322 A MX9708322 A MX 9708322A MX 9708322 A MX9708322 A MX 9708322A MX 9708322 A MX9708322 A MX 9708322A
Authority
MX
Mexico
Prior art keywords
group
azacycloalcane
therapy
derivatives
applications
Prior art date
Application number
MX9708322A
Other languages
English (en)
Other versions
MXPA97008322A (es
Inventor
Manuel Bedoya Zurita
Juan Antonio Diaz Martin
Gregorio Del Sol Moreno
Ulpiano Martin-Escudero Perez
Maria Dolores Jimenez Bargueno
Magali Romanach Ferrer
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of MX9708322A publication Critical patent/MX9708322A/es
Publication of MXPA97008322A publication Critical patent/MXPA97008322A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Derivados de azacicloalcano que tiene la formula general (I) en donde: R1 y R2 representan un átomo de hidrogeno, un grupo alquilo o un grupo fenilo, o R1 y R2 tomados juntos forman un grupo oxo, R3 es un átomo de hidrogeno o un grupo alquilo o R3 forma un grupo metileno, R4 es un grupo aromático o, cuando R3 forma un grupo metileno, R4 es un grupo fenileno en el cual un átomo de carbono que está enlazado a Y y otro átomo de carbono, adyacente al átomo de carbono formado está enlazado al grupo metileno, R5 es cualquiera de un grupo OR7, en donde R7 es un átomo de hidrogeno o un grupo bencilo, o un grupo N4-metilpiperazinilo, o aun grupo NHR8 donde R8 es un grupo opcionalmente sustituido, n es igual a 1 o 2 X es CH, O o N, e Y es CH2, O o S, su proceso de preparacion y sus aplicaciones en terapia.
MXPA/A/1997/008322A 1995-05-03 1997-10-29 Derivados de azacicloalcano, su preparacion y susaplicaciones en terapia MXPA97008322A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9505260A FR2733750B1 (fr) 1995-05-03 1995-05-03 Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
FR95/05260 1995-05-03

Publications (2)

Publication Number Publication Date
MX9708322A true MX9708322A (es) 1998-06-28
MXPA97008322A MXPA97008322A (es) 1998-10-30

Family

ID=

Also Published As

Publication number Publication date
EP0823912A1 (fr) 1998-02-18
SK147897A3 (en) 1998-05-06
NZ307230A (en) 1998-11-25
PL323177A1 (en) 1998-03-16
AR001838A1 (es) 1997-12-10
TR199701287T1 (xx) 1998-03-21
BR9608309A (pt) 1999-01-26
CZ346697A3 (cs) 1998-02-18
WO1996034870A1 (fr) 1996-11-07
CO4750652A1 (es) 1999-03-31
BG102015A (en) 1998-08-31
ZA963485B (en) 1996-11-25
CA2220015A1 (fr) 1996-11-07
FR2733750A1 (fr) 1996-11-08
IL118119A0 (en) 1996-09-12
US5869518A (en) 1999-02-09
HUP9903886A2 (hu) 2000-03-28
KR19990008276A (ko) 1999-01-25
EE9700288A (et) 1998-04-15
HUP9903886A3 (en) 2000-04-28
JPH11504913A (ja) 1999-05-11
FR2733750B1 (fr) 1997-06-13
NO975020L (no) 1998-01-05
NO975020D0 (no) 1997-10-31
AU699120B2 (en) 1998-11-19
AU5652096A (en) 1996-11-21

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FA Abandonment or withdrawal