ES2051753T3 - N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas. - Google Patents

N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas.

Info

Publication number
ES2051753T3
ES2051753T3 ES87310859T ES87310859T ES2051753T3 ES 2051753 T3 ES2051753 T3 ES 2051753T3 ES 87310859 T ES87310859 T ES 87310859T ES 87310859 T ES87310859 T ES 87310859T ES 2051753 T3 ES2051753 T3 ES 2051753T3
Authority
ES
Spain
Prior art keywords
ansiolytic
azabiciclo
thiobenzamides
octo
benzamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87310859T
Other languages
English (en)
Inventor
Robert John Naylor
Brenda Naylor-Costall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629962A external-priority patent/GB8629962D0/en
Priority claimed from GB878709508A external-priority patent/GB8709508D0/en
Priority claimed from GB878717050A external-priority patent/GB8717050D0/en
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Application granted granted Critical
Publication of ES2051753T3 publication Critical patent/ES2051753T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Abstract

LOS COMPUESTOS DE FORMULA GENERAL (I), EN LA QUE X REPRESENTA O O S; R1 REPRESENTA ALQUILO INFERIOR; R2 REPRESENTA HIDROGENO, HALO, 4,5-BENZO, ALCOXI INFERIOR, AMINO, METILAMINO O DIMETILAMINO; R3 REPRESENTA HIDROGENO O ALQUILO INFERIOR; Y N ES 1 O 2 Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES, TIENEN ACTIVIDAD ANSIOLITICA. EN PARTICULAR, TIENEN ACTIVIDAD CONTRA LA ANSIEDAD INDUCIDA POR LA RETIRADA DE SUSTANCIAS INGERIDAS, TALES COMO NARCOTICOS (POR EJEMPLO COCAINA), ALCOHOL Y NICOTINA.
ES87310859T 1986-12-16 1987-12-10 N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas. Expired - Lifetime ES2051753T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB868629962A GB8629962D0 (en) 1986-12-16 1986-12-16 Benzamides & thiobenzamides
GB878709508A GB8709508D0 (en) 1987-04-22 1987-04-22 Benzamides & thiobenzamides
GB878717050A GB8717050D0 (en) 1987-07-20 1987-07-20 Benzamides & thiobenzamides

Publications (1)

Publication Number Publication Date
ES2051753T3 true ES2051753T3 (es) 1994-07-01

Family

ID=27263251

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87310859T Expired - Lifetime ES2051753T3 (es) 1986-12-16 1987-12-10 N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas.

Country Status (12)

Country Link
US (1) US4908370A (es)
EP (1) EP0272052B1 (es)
AU (1) AU608793B2 (es)
CA (1) CA1309660C (es)
DE (1) DE3780276T2 (es)
DK (1) DK658687A (es)
ES (1) ES2051753T3 (es)
GR (1) GR3005667T3 (es)
IL (1) IL84834A0 (es)
NZ (1) NZ222931A (es)
PH (1) PH23937A (es)
PT (1) PT86362B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3688296T2 (de) * 1985-03-14 1993-11-04 Beecham Group Plc Arzneimittel zur behandlung von erbrechen.
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
US5198447A (en) * 1986-11-21 1993-03-30 Glaxo Group Limited Medicaments
DE3777805D1 (de) * 1986-11-21 1992-04-30 Glaxo Group Ltd Arzneimittel zur behandlung oder vorbeugung des entzugssyndromes.
US5246941A (en) * 1986-12-17 1993-09-21 Glaxo Group Limited Method for the treatment of depression
GB8720805D0 (en) * 1987-09-04 1987-10-14 Naylor R J 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
EP0311724A1 (en) * 1987-10-16 1989-04-19 Synthelabo Anxiolytic-R-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
EP0353372B1 (en) * 1988-08-04 1993-02-03 Synthelabo Antischizophrenic-S-N-(1-azabicyclo[2.2.2.]oct-3-yl) benzamides and thiobenzamides
GB8820650D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
DK0422154T3 (da) * 1989-04-21 1994-03-07 Sandoz Ag Terapeutisk anvendelse af 5-HT3-receptorantagonister
AU654013B2 (en) * 1991-03-13 1994-10-20 Regents Of The University Of Minnesota 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane
US5273972A (en) * 1992-03-26 1993-12-28 A. H. Robins Company, Incorporated [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates
US5837711A (en) * 1992-10-28 1998-11-17 Pfizer Inc. Substituted quinuclidines as substance P antagonists
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
AU2001282873A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
EP1381603A2 (en) 2000-08-18 2004-01-21 PHARMACIA & UPJOHN COMPANY Quinuclidine-substituedaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
JP2005504059A (ja) * 2001-08-24 2005-02-10 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー 疾患を処置するための置換アリール７−アザ［２．２．１］ビシクロヘプタン
WO2003070728A2 (en) 2002-02-15 2003-08-28 Pharmacia & Upjohn Company Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders
JP2005525357A (ja) * 2002-02-20 2005-08-25 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー α７ニコチン性アセチルコリン受容体活性を伴うアザ二環式化合物
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2010042799A2 (en) 2008-10-09 2010-04-15 Howard Hughes Medical Institute Novel chimeric ligand-gated ion channels and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2548968A1 (de) * 1975-11-03 1977-05-12 Thomae Gmbh Dr K Neue amino-benzoesaeureamide
US4093734A (en) * 1975-11-03 1978-06-06 Boehringer Ingelheim Gmbh Amino-benzoic acid amides
AU532065B2 (en) * 1979-06-08 1983-09-15 Philip Morris Products Inc. Optical perforating apparatus
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
FR2529548A1 (fr) * 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
US4593034A (en) * 1984-04-06 1986-06-03 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
US4870181A (en) * 1985-02-04 1989-09-26 A. H. Robins Company, Incorporated Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides
DE3688296T2 (de) * 1985-03-14 1993-11-04 Beecham Group Plc Arzneimittel zur behandlung von erbrechen.
GB8511988D0 (en) * 1985-05-11 1985-06-19 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
AU8254687A (en) 1988-06-16
EP0272052A1 (en) 1988-06-22
IL84834A0 (en) 1988-06-30
DK658687D0 (da) 1987-12-15
PT86362B (pt) 1990-11-07
NZ222931A (en) 1991-08-27
DE3780276T2 (de) 1993-02-25
DK658687A (da) 1988-06-17
GR3005667T3 (es) 1993-06-07
PT86362A (en) 1988-01-01
AU608793B2 (en) 1991-04-18
EP0272052B1 (en) 1992-07-08
PH23937A (en) 1990-01-23
CA1309660C (en) 1992-11-03
DE3780276D1 (de) 1992-08-13
US4908370A (en) 1990-03-13

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