DK217588A - 17beta-(cyclopropylamino)-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler - Google Patents

17beta-(cyclopropylamino)-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler

Info

Publication number
DK217588A
DK217588A DK217588A DK217588A DK217588A DK 217588 A DK217588 A DK 217588A DK 217588 A DK217588 A DK 217588A DK 217588 A DK217588 A DK 217588A DK 217588 A DK217588 A DK 217588A
Authority
DK
Denmark
Prior art keywords
androst
cyclopropylamino
17beta
3beta
older
Prior art date
Application number
DK217588A
Other languages
English (en)
Other versions
DK217588D0 (da
Inventor
Michael R Angelastro
Thomas R Blohm
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK217588D0 publication Critical patent/DK217588D0/da
Publication of DK217588A publication Critical patent/DK217588A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
DK217588A 1987-04-22 1988-04-21 17beta-(cyclopropylamino)-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler DK217588A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4117287A 1987-04-22 1987-04-22

Publications (2)

Publication Number Publication Date
DK217588D0 DK217588D0 (da) 1988-04-21
DK217588A true DK217588A (da) 1988-10-23

Family

ID=21915133

Family Applications (1)

Application Number Title Priority Date Filing Date
DK217588A DK217588A (da) 1987-04-22 1988-04-21 17beta-(cyclopropylamino)-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler

Country Status (19)

Country Link
EP (1) EP0288053B1 (da)
JP (1) JP2711672B2 (da)
KR (1) KR960015037B1 (da)
CN (1) CN88102176A (da)
AT (1) ATE67211T1 (da)
AU (1) AU606677B2 (da)
CA (1) CA1326234C (da)
DE (1) DE3864725D1 (da)
DK (1) DK217588A (da)
ES (1) ES2038712T3 (da)
FI (1) FI88397C (da)
GR (1) GR3002713T3 (da)
HU (1) HU198511B (da)
IL (1) IL86139A (da)
NO (1) NO169346C (da)
NZ (1) NZ224288A (da)
PH (1) PH24090A (da)
PT (1) PT87294B (da)
ZA (1) ZA882717B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4891367A (en) * 1987-04-22 1990-01-02 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US4954488A (en) * 1989-06-14 1990-09-04 Merrell Dow Pharmaceuticals Inc. Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives
US4966898A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US5256408A (en) * 1990-06-12 1993-10-26 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5209926A (en) * 1990-06-12 1993-05-11 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5252319A (en) * 1990-06-12 1993-10-12 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
CZ287434B6 (en) * 1992-03-31 2000-11-15 British Tech Group Use of steroids, substituted in position 17, steroids functioning as carcinostatics and pharmaceutical preparation containing thereof
US5604213A (en) * 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
PL204934B1 (pl) 2000-11-17 2010-02-26 Takeda Pharmaceutical Pochodne imidazolu i ich sole diastereomeryczne, kompozycje farmaceutyczne i środki do zmniejszania poziomu androgenu zawierające te pochodne oraz sposoby ich wytwarzania
US6960586B2 (en) 2000-11-20 2005-11-01 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
DE60139639D1 (de) 2000-12-08 2009-10-01 Takeda Pharmaceutical Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung
MA33451B1 (fr) 2009-06-26 2012-07-03 Novartis Ag Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17
CA2807149C (en) 2010-08-04 2017-05-02 Pellficure Pharmaceuticals, Inc. Novel treatment of prostate carcinoma
EP2627648A1 (en) 2010-09-16 2013-08-21 Novartis AG 17aHYDROXYLASE/C17,20-LYASE INHIBITORS
US9029399B2 (en) 2011-04-28 2015-05-12 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
CA2902335C (en) 2013-03-14 2021-09-14 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
EP3191087A1 (en) 2014-09-12 2017-07-19 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
WO2018080933A1 (en) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL302932A (da) * 1962-12-31
US4891367A (en) * 1987-04-22 1990-01-02 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Also Published As

Publication number Publication date
AU1471988A (en) 1988-10-27
JP2711672B2 (ja) 1998-02-10
AU606677B2 (en) 1991-02-14
CN88102176A (zh) 1988-11-23
NZ224288A (en) 1989-12-21
PH24090A (en) 1990-03-05
GR3002713T3 (en) 1993-01-25
ES2038712T3 (es) 1993-08-01
JPS63284195A (ja) 1988-11-21
FI881877A0 (fi) 1988-04-21
IL86139A (en) 1993-02-21
IL86139A0 (en) 1988-11-15
PT87294B (pt) 1992-08-31
NO169346B (no) 1992-03-02
ATE67211T1 (de) 1991-09-15
HUT47307A (en) 1989-02-28
HU198511B (en) 1989-10-30
PT87294A (pt) 1988-05-01
FI88397B (fi) 1993-01-29
DK217588D0 (da) 1988-04-21
ZA882717B (en) 1988-10-17
NO169346C (no) 1992-06-10
FI88397C (fi) 1993-05-10
KR880012633A (ko) 1988-11-28
EP0288053B1 (en) 1991-09-11
KR960015037B1 (ko) 1996-10-24
EP0288053A1 (en) 1988-10-26
CA1326234C (en) 1994-01-18
NO881746L (no) 1988-10-24
NO881746D0 (no) 1988-04-21
DE3864725D1 (de) 1991-10-17
FI881877A (fi) 1988-10-23

Similar Documents

Publication Publication Date Title
DK217588A (da) 17beta-(cyclopropylamino)-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler
NO903564D0 (no) Fremgangsmaate for fremstilling av 4-substituerte 17beta-(cyklopropylamino)androst-5-en-3beta-ol-derivater.
TW221056B (da)
DK505584D0 (da) Administrationssaet og farmaceutiske praeparater til anvendelse dertil
FI890257A (fi) Menetelmä terapeuttisesti käyttökelpoisten pyridiinijohdannaisten valmistamiseksi
ATE89728T1 (de) Verwendung von dihydroergotamin und seinen salzen zur lokalen behandlung trophischer stoerungen.
DK217488A (da) 17beta-(cyclopropyloxy(thio))-androst-5-en-3beta-olderivater, deres fremstilling og anvendelse som laegemidler
IL111580A (en) Use of melatonin derivatives in the preparation of pharmaceutical compositions for use in treating sleep disorders
DK0411268T3 (da) Dibenzo(1,5)dioxocin-5-on-derivater, deres anvendelse i lægemidler og fremgangsmåde til deres fremstilling
ES2009689A6 (es) Procedimiento para preparar derivados de 3-piperidina-carbaldehido-oxima.
DK0538690T3 (da) Arylquinolyl-substituerede 1,4-dihydropyridin-dicarboxylsyrederivater, fremgangsmåde til deres fremstilling af deres anvendelse i lægemidler
DK1025101T3 (da) Naphtho-imidazo[1,2-a]pyridinderivater, deres fremstilling og deres anvendelse ved behandlingen af sygdomme i centralnervesystemet
EP0253650A3 (en) Improvements relating to benzothiophene derivatives
NO922635L (no) Ny anvendelse av benzimidazolin-2-okso-1-karboksylsyrederivater
DK0576913T3 (da) Digitoxigenin og dihydrodigitoxigenin 3 beta-derivater samt farmaceutiske præparater indeholdende sådanne til behandling af hypertension
DK0950053T3 (da) Hidtil ukendte benzoylalkyl.1,2,3,6-tetrahydropyridinderivater

Legal Events

Date Code Title Description
ATS Application withdrawn