DE60020885D1 - TETRAHYDROPYRIDINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM - Google Patents

TETRAHYDROPYRIDINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Info

Publication number
DE60020885D1
DE60020885D1 DE60020885T DE60020885T DE60020885D1 DE 60020885 D1 DE60020885 D1 DE 60020885D1 DE 60020885 T DE60020885 T DE 60020885T DE 60020885 T DE60020885 T DE 60020885T DE 60020885 D1 DE60020885 D1 DE 60020885D1
Authority
DE
Germany
Prior art keywords
tetrahydropyridines
production
pharmaceutical preparations
represent
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60020885T
Other languages
German (de)
Other versions
DE60020885T2 (en
Inventor
Marco Baroni
Bernard Bourrie
Rosanna Cardamone
Pierre Casellas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Application granted granted Critical
Publication of DE60020885D1 publication Critical patent/DE60020885D1/en
Publication of DE60020885T2 publication Critical patent/DE60020885T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to compounds of formula (I):in whichR1 represents a hydrogen or halogen atom, or a group CF3;R2 and R3 represent, independently, a hydrogen atom or a methyl group;n and n' each represent, independently, 0 or 1;* represents the positions of attachment;A represents N or CH;X represents a sulfur or oxygen atom;R4 and R5 represent, independently, a hydrogen atom or a (C1-C6) alkyl group;and also their salts or solvates, to a method for the preparation thereof and to the pharmaceutical compositions containing them.
DE60020885T 2000-01-06 2000-12-29 TETRAHYDROPYRIDINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM Expired - Lifetime DE60020885T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0000113 2000-01-06
FR0000113A FR2803593B1 (en) 2000-01-06 2000-01-06 NOVEL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR2000/003741 WO2001049684A1 (en) 2000-01-06 2000-12-29 Novel tetrahydropyridines, preparation method and pharmaceutical compositions containing same

Publications (2)

Publication Number Publication Date
DE60020885D1 true DE60020885D1 (en) 2005-07-21
DE60020885T2 DE60020885T2 (en) 2006-05-11

Family

ID=8845654

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60020885T Expired - Lifetime DE60020885T2 (en) 2000-01-06 2000-12-29 TETRAHYDROPYRIDINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Country Status (28)

Country Link
US (1) US6689797B2 (en)
EP (1) EP1248785B1 (en)
JP (1) JP2004501861A (en)
KR (1) KR100755103B1 (en)
CN (1) CN1200939C (en)
AT (1) ATE297918T1 (en)
AU (1) AU782650B2 (en)
BR (1) BR0016921A (en)
CA (1) CA2395969C (en)
CZ (1) CZ300658B6 (en)
DE (1) DE60020885T2 (en)
EA (1) EA004858B1 (en)
EE (1) EE04814B1 (en)
FR (1) FR2803593B1 (en)
HK (1) HK1050532A1 (en)
HU (1) HU224815B1 (en)
IL (1) IL150605A0 (en)
IS (1) IS2472B (en)
ME (1) MEP21808A (en)
MX (1) MXPA02006709A (en)
NO (1) NO322598B1 (en)
NZ (1) NZ519723A (en)
PL (1) PL202761B1 (en)
RS (1) RS50432B (en)
SK (1) SK285557B6 (en)
UA (1) UA72017C2 (en)
WO (1) WO2001049684A1 (en)
ZA (1) ZA200205223B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301566B6 (en) * 1999-10-22 2010-04-21 Sanofi-Aventis Derivatives of phenyl- and pyridyl-tetrahydropyridine, process of their preparation and pharmaceutical composition in which they are comprised
FR2831166B1 (en) * 2001-10-18 2004-02-27 Sanofi Synthelabo ARALKYL-TETRAHYDRO-PYRIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2832405B1 (en) * 2001-11-19 2004-12-10 Sanofi Synthelabo TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES NITROGEN, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
UA77526C2 (en) 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862967B1 (en) * 2003-12-01 2006-08-04 Sanofi Synthelabo (4-PHENYLPIPERAZIN-1-YL) ACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2862968B1 (en) * 2003-12-01 2006-08-04 Sanofi Synthelabo 4 - [(ARYLMETHYL) AMINOMETHYL] PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
AR065718A1 (en) * 2007-03-15 2009-06-24 Novartis Ag NITROGEN HETEROCICLICAL COMPOUNDS, USEFUL IN THE DIAGNOSIS AND TREATMENT OF HYPERPROLIFERATIVE DISORDERS.
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
FR2953836B1 (en) * 2009-12-14 2012-03-16 Sanofi Aventis NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75
US11129746B2 (en) 2010-06-23 2021-09-28 Dental Choice Holdings Llc Method and oral appliance for improving air intake and reducing bruxism
EP2606894A1 (en) 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists
CA3085388A1 (en) 2017-12-12 2019-06-20 Queen's University At Kingston Compounds and methods for inhibiting cyp26 enzymes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (en) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidine derivatives Process for their production and pharmaceutical preparations containing these compounds
US5273977A (en) * 1990-11-05 1993-12-28 Warner-Lambert Company Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
PT100441A (en) * 1991-05-02 1993-09-30 Smithkline Beecham Corp PIRROLIDINONES, ITS PREPARATION PROCESS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE
FR2736053B1 (en) * 1995-06-28 1997-09-19 Sanofi Sa NEWS 1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES
GB9604036D0 (en) * 1996-02-26 1996-04-24 Merck Sharp & Dohme Therapeutic agents
FR2751645B1 (en) * 1996-07-29 1998-12-24 Sanofi Sa AMINES FOR THE MANUFACTURE OF DRUGS TO PREVENT THE PROLIFERATION OF TUMOR CELLS
DE19826841A1 (en) * 1998-06-16 1999-12-23 Merck Patent Gmbh Arylalkanoylpyridazines

Also Published As

Publication number Publication date
EA004858B1 (en) 2004-08-26
RS50432B (en) 2009-12-31
PL202761B1 (en) 2009-07-31
ATE297918T1 (en) 2005-07-15
EP1248785B1 (en) 2005-06-15
IL150605A0 (en) 2003-02-12
KR100755103B1 (en) 2007-09-04
BR0016921A (en) 2002-10-15
AU782650B2 (en) 2005-08-18
HUP0204394A3 (en) 2005-04-28
SK285557B6 (en) 2007-03-01
ZA200205223B (en) 2004-01-26
PL357082A1 (en) 2004-07-12
MXPA02006709A (en) 2002-10-23
JP2004501861A (en) 2004-01-22
NO20023251D0 (en) 2002-07-04
IS2472B (en) 2008-12-15
WO2001049684A1 (en) 2001-07-12
UA72017C2 (en) 2005-01-17
SK9622002A3 (en) 2003-03-04
YU51302A (en) 2005-06-10
NO322598B1 (en) 2006-10-30
MEP21808A (en) 2010-06-10
CZ300658B6 (en) 2009-07-08
FR2803593B1 (en) 2002-02-15
US20030083347A1 (en) 2003-05-01
CN1433412A (en) 2003-07-30
NO20023251L (en) 2002-09-06
FR2803593A1 (en) 2001-07-13
CA2395969C (en) 2009-05-19
EA200200611A1 (en) 2002-12-26
AU3031101A (en) 2001-07-16
HU224815B1 (en) 2006-02-28
EE04814B1 (en) 2007-04-16
EP1248785A1 (en) 2002-10-16
US6689797B2 (en) 2004-02-10
KR20020063291A (en) 2002-08-01
DE60020885T2 (en) 2006-05-11
CZ20022302A3 (en) 2002-10-16
CN1200939C (en) 2005-05-11
HK1050532A1 (en) 2003-06-27
HUP0204394A2 (en) 2003-05-28
CA2395969A1 (en) 2002-07-03
IS6452A (en) 2002-06-28
NZ519723A (en) 2005-08-26
EE200200382A (en) 2003-12-15

Similar Documents

Publication Publication Date Title
HUP0203836A2 (en) 1,3-disubstituted pyrrololidines as alpha-2-adrenoceptor antagonists, process for their preparation and pharmaceutical compositions containing them and their use
HUP0300922A2 (en) Novel compounds, process for their preparation, pharmaceutical compositions containing them and their use
ATE124047T1 (en) OXAZOLOPYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ATE9793T1 (en) 5-OXO- AND 5-THIOXOPROLINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE60020885D1 (en) TETRAHYDROPYRIDINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
HUP9802937A2 (en) Benzo[g]quuinoline derivatives, pharmaceutical compositions containing them and their use
ATE156829T1 (en) SUBSTITUTED AMINOPHOSPHONATE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2000047584A3 (en) Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
CO4980887A1 (en) NEW 3,4-DIARILTIAZOLINA-2-UNO OR 2-TIONO DERIVATIVES, THEIR PREPARATION METHODS AND THERAPEUTIC USE
ATA49688A (en) NEW PYRIDAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
MY135774A (en) Hexahydroazepine derivatives, a process for their preparation and pharmaceutical compositions containing them.
DE69028342T2 (en) Cephalosporin compounds and process for their preparation
ATE116647T1 (en) THIOPHENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE60220779D1 (en) TETRAHYDROPYRIDYL-ALKYL-HETEROZYKLE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEY
DE3773597D1 (en) 1,4-DIHYDROPYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
AU639154B2 (en) New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
DK0913151T3 (en) Anti-helicobacter Pylori preparations containing 1-methylcarbapenem derivatives as the active ingredient
JO2289B1 (en) Prdruge to nmda receptor ligands
IL115085A0 (en) Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
AR003530A1 (en) DERIVATIVES OF 4- (CYCLLOALKYL) PIPERIDINES AND OF 4- (CYCLE ALKYL RENT) PIPERIDINES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ATE302750T1 (en) SUBSTITUTED BIPHENOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREOF

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC