WO2000034237A3 - Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses - Google Patents

Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses Download PDF

Info

Publication number
WO2000034237A3
WO2000034237A3 PCT/US1999/028844 US9928844W WO0034237A3 WO 2000034237 A3 WO2000034237 A3 WO 2000034237A3 US 9928844 W US9928844 W US 9928844W WO 0034237 A3 WO0034237 A3 WO 0034237A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbon atoms
alkyl
perhaloalkyl
aryl
hydrogen
Prior art date
Application number
PCT/US1999/028844
Other languages
French (fr)
Other versions
WO2000034237A2 (en
Inventor
Jonathan David Bloom
Martin Joseph Digrandi
Russell George Dushin
Stanley Albert Lang
Bryan Mark O'hara
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000586685A priority Critical patent/JP2002531544A/en
Application filed by American Home Prod filed Critical American Home Prod
Priority to BR9916041-2A priority patent/BR9916041A/en
Priority to AU31112/00A priority patent/AU3111200A/en
Priority to EA200100640A priority patent/EA200100640A1/en
Priority to EP99965132A priority patent/EP1137633A2/en
Priority to CA002350899A priority patent/CA2350899A1/en
Priority to PL99349131A priority patent/PL349131A1/en
Priority to IL14320499A priority patent/IL143204A0/en
Priority to KR1020017007052A priority patent/KR20010087413A/en
Priority to HU0104944A priority patent/HUP0104944A3/en
Publication of WO2000034237A2 publication Critical patent/WO2000034237A2/en
Publication of WO2000034237A3 publication Critical patent/WO2000034237A3/en
Priority to NO20012834A priority patent/NO20012834L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Abstract

Compounds of formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, -CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; G is alkyl of 1 to 6 carbon atoms; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or pharmaceutical salts thereof, are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
PCT/US1999/028844 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses WO2000034237A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA002350899A CA2350899A1 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
BR9916041-2A BR9916041A (en) 1998-12-09 1999-12-06 Compound, pharmaceutical composition, and methods to inhibit the replication of a herpes virus and to treat a patient suffering from an infection with herpes virus
AU31112/00A AU3111200A (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
EA200100640A EA200100640A1 (en) 1998-12-09 1999-12-06 HERPES VIRUS INHIBITORS, PRESENTING ACETAMIDE AND SUBSTITUTED ACETAMIDE-CONTAINING THIOMOVA
EP99965132A EP1137633A2 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
JP2000586685A JP2002531544A (en) 1998-12-09 1999-12-06 Herpesvirus thiourea inhibitors containing acetamide and substituted acetamide
PL99349131A PL349131A1 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
HU0104944A HUP0104944A3 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
KR1020017007052A KR20010087413A (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
IL14320499A IL143204A0 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
NO20012834A NO20012834L (en) 1998-12-09 2001-06-08 Acetamide- and substituted acetamide-containing thiourea inhibitors for herpes virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20831698A 1998-12-09 1998-12-09
US09/208,316 1998-12-09

Publications (2)

Publication Number Publication Date
WO2000034237A2 WO2000034237A2 (en) 2000-06-15
WO2000034237A3 true WO2000034237A3 (en) 2000-11-23

Family

ID=22774137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/028844 WO2000034237A2 (en) 1998-12-09 1999-12-06 Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Country Status (15)

Country Link
EP (1) EP1137633A2 (en)
JP (1) JP2002531544A (en)
KR (1) KR20010087413A (en)
CN (1) CN1333750A (en)
AU (1) AU3111200A (en)
BR (1) BR9916041A (en)
CA (1) CA2350899A1 (en)
CZ (1) CZ20012060A3 (en)
EA (1) EA200100640A1 (en)
HU (1) HUP0104944A3 (en)
IL (1) IL143204A0 (en)
NO (1) NO20012834L (en)
PL (1) PL349131A1 (en)
WO (1) WO2000034237A2 (en)
ZA (1) ZA200104142B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
JP4690889B2 (en) * 2002-10-24 2011-06-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Methylene urea derivative
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
EP1660661A2 (en) 2003-08-08 2006-05-31 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
CA2772017C (en) 2003-08-29 2016-05-31 Mitsui Chemicals, Inc. Agricultural/horticultural insecticide and method for using the same
AU2005221151A1 (en) 2004-03-09 2005-09-22 Arriva Pharmaceuticals, Inc. Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor
EP2074085A2 (en) * 2006-10-13 2009-07-01 Lica Pharmaceuticals A/S Anti-infective thiourea compounds
ES2382055T3 (en) 2006-11-02 2012-06-04 Millennium Pharmaceuticals, Inc. Methods for synthesizing pharmaceutical salts of a factor Xa inhibitor
CN108619123A (en) * 2018-03-13 2018-10-09 武汉威立得生物医药有限公司 Tenovin-1 is preparing the application in preventing nerpes vinrus hominis's infection medicine
WO2019193541A1 (en) * 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors
CN112807294B (en) * 2019-11-18 2023-09-05 武汉大学 Application of acyl thiourea compound in preparation of medicines for treating or preventing herpes simplex virus type I infection
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045259A2 (en) * 1997-04-10 1998-10-15 Pharmacia & Upjohn Company Polyaromatic antiviral compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045259A2 (en) * 1997-04-10 1998-10-15 Pharmacia & Upjohn Company Polyaromatic antiviral compositions

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 56, no. 7, 2 April 1962, Columbus, Ohio, US; abstract no. 7185a, XP002147302 *
CHEMICAL ABSTRACTS, vol. 64, no. 2, 17 January 1966, Columbus, Ohio, US; abstract no. 2452e, XP002147301 *
DATABASE CAOLD CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002147303 *
E. WINKELMANN ET AL, ARZNEIM. FORSCH., vol. 19, 1969, pages 543 - 558, XP002104044 *
K. GANAPATHI ET AL, PROC.-INDIAN ACAD. SCI., SECT. A, vol. 37, 1953, XP000925884 *
N. DAT-XUONG ET AL, ANN. INST. PASTEUR, vol. 109, no. 4, 1965, pages 600 - 604, XP000900806 *
NG. PH. BUU-HOI ET AL, J. CHEM. SOC., 1958, pages 2815 - 2821, XP002128092 *
R.G. DUBENKO ET AL, UKRAIN. KHIM. ZHUR., vol. 27, 1961, pages 673 - 675 *
S. ABUZAR ET AL, INDIAN J. CHEM., SECT. B, vol. 20b, no. 3, 1981, pages 230 - 233, XP000925880 *
Y.-L. WU, YAO HSUEH PAO, vol. 12, no. 8, 1965, pages 523 - 532 *

Also Published As

Publication number Publication date
NO20012834L (en) 2001-08-07
CZ20012060A3 (en) 2001-11-14
CN1333750A (en) 2002-01-30
HUP0104944A2 (en) 2002-04-29
EA200100640A1 (en) 2001-12-24
CA2350899A1 (en) 2000-06-15
WO2000034237A2 (en) 2000-06-15
KR20010087413A (en) 2001-09-15
AU3111200A (en) 2000-06-26
ZA200104142B (en) 2002-10-25
EP1137633A2 (en) 2001-10-04
NO20012834D0 (en) 2001-06-08
HUP0104944A3 (en) 2003-03-28
BR9916041A (en) 2001-12-04
JP2002531544A (en) 2002-09-24
IL143204A0 (en) 2002-04-21
PL349131A1 (en) 2002-07-01

Similar Documents

Publication Publication Date Title
WO2000034237A3 (en) Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
NZ505362A (en) 4-hydroxyquinoline-3-carboxamides and -hydrazides useful as antiviral agents
ZA864570B (en) (meth)-acrylic acid derivatives of tricyclodecanes and their use
FI952424A0 (en) 11,21-bisphenyl-19-norpregaanijohdannaisia
BG105583A (en) Thiourea as inhibitor of herpes viruses
WO2000034258A3 (en) Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
NO165072C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 3-VINYL AND 3-ETHYNYL-8-CARBOLINE DERIVATIVES.
WO2000034260A3 (en) Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
HUP0203405A2 (en) A substituted phenylenediamine group and heterocyclic carboxamide group containing thiourea derivatives inhibitors of herpes viruses, pharmaceutical compositions containing them and their use
HUP9902992A3 (en) Alpha-amino acid amides, preparation thereof and pharmaceutical compositions containing them
NO20012836L (en) Thiourea inhibitors of herpes virus
EA200100635A1 (en) DERIVATIVES OF THIOMOCHEVIA AS HERPES VIRUS INHIBITORS
ATE156473T1 (en) METHOD FOR REDUCING IMPURITIES IN AQUEOUS MONOMER SOLUTIONS
DE3465085D1 (en) Derivatives of 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-n-phenyl acetamide, their preparation and their therapeutical use
GR3006939T3 (en)
DK398189D0 (en) 2-AMINO-4-MORPHOLINO-6-PROPYL-1,3,5-TRIAZINES AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUNDS
MX9703497A (en) 2-[(2-alkoxy-6-trifluoromethyl pyrimidine-4-yl)-oxymethylene]-phenyl-acetic acid derivatives, processes and intermediate products for their production and their use.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99815640.X

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1999965132

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2350899

Country of ref document: CA

Ref document number: 2350899

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 31112/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 143204

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2001/04142

Country of ref document: ZA

Ref document number: 200104142

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 512107

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 1020017007052

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/005680

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2000 586685

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PV2001-2060

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 200100640

Country of ref document: EA

WWP Wipo information: published in national office

Ref document number: 1020017007052

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1999965132

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2001-2060

Country of ref document: CZ

WWR Wipo information: refused in national office

Ref document number: PV2001-2060

Country of ref document: CZ

WWW Wipo information: withdrawn in national office

Ref document number: 1999965132

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1020017007052

Country of ref document: KR