EA200100637A1 - INHIBITORS OF HERPES VIRUSES BASED ON THIOMOCHEVINA - Google Patents

INHIBITORS OF HERPES VIRUSES BASED ON THIOMOCHEVINA

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Publication number
EA200100637A1
EA200100637A1 EA200100637A EA200100637A EA200100637A1 EA 200100637 A1 EA200100637 A1 EA 200100637A1 EA 200100637 A EA200100637 A EA 200100637A EA 200100637 A EA200100637 A EA 200100637A EA 200100637 A1 EA200100637 A1 EA 200100637A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbon atoms
alkyl
heteroaryl
sor
cor
Prior art date
Application number
EA200100637A
Other languages
Russian (ru)
Inventor
Джонатан Дэвид Блум
Мартин Джозеф Дигранди
Расселл Джордж Дашин
Стэнли Альберт Лэнг
Брайан Марк О'Хара
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Priority claimed from PCT/US1999/028892 external-priority patent/WO2000034269A1/en
Publication of EA200100637A1 publication Critical patent/EA200100637A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Соединения формулы (1), в которой R-Rнезависимо выбирают из группы, включающей водород, алкил с 1-6 атомами углерода, алкенил с 2-6 атомами углерода, алкинил с 2-6 атомами углерода, пергалогеналкил с 1-6 атомами углерода, циклоалкил с 3-10 атомами углерода, гетероциклоалкил с 3-10 углеродными членами, арил, гетероарил, галоген, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, -NRN(RR), -N(RR) или W-Y-(CH)-Z; либо Rи Rили Rи R, вместе взятые, образуют 3-7-членный гетероциклоалкил или 3-7-членный гетероарил; Rи Rнезависимо означают водород, алкил с 1-6 атомами углерода, пергалогеналкил с 1-6 атомами углерода или арил; Rозначает водород, алкил с 1-6 атомами углерода, пергалогеналкил с 1-6 атомами углерода, циклоалкил с 3-10 атомами углерода, гетероциклоалкил с 3-10 членами, арил или гетероарил, либо Rи R, вместе взятые, образуют 3-7-членный гетероциклоалкил; А означает гетероарил; W означает O, NRили отсутствует; Y означает -(CO)-, -(CO)- или отсутствует; Z означает алкил с 1-4 атомами углерода, -CN, -COR, COR, -CONRR, -OCOR, -NRCOR, -OCONR, -OR, -SR, -SOR, -SOR, SRN(RR), -N(RR) или фенил; G означает арил или гетероарил; Х означает связь, -NH, алкил с 1-6 атомами углерода, алкенил с 1-6 атомами углерода, алкокси с 1-6 атомами углерода, тиоалкил с 1-6 атомами углерода, алкиламино с 1-6 атомами углерода или (CH)J; J означает алкил с 1-6 атомами углерода, циклоалкил с 3-7 атомами углерода, фенил или бензил; и n является целым числом от 1 до 6; которые позволяют эффективно лечить заболевания, обусловленные вирусами герпеса, включая цитомегаловирус человека, вирусы простого герпеса, вирус Эпштейна-Барра, вирус ветряной оспы, вирусы герпеса человека 6 и 7 и вирус герпеса Капоши.Международная заявка была опубликована вместе с отчетом о международном поиске.The compounds of formula (1) in which R-R is independently selected from the group consisting of hydrogen, alkyl with 1-6 carbon atoms, alkenyl with 2-6 carbon atoms, alkynyl with 2-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, cycloalkyl with 3-10 carbon atoms, heterocycloalkyl with 3-10 carbon members, aryl, heteroaryl, halogen, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, - NRN (RR), -N (RR) or WY- (CH) -Z; either R1 and R1 or R1 and R4, taken together, form a 3-7 membered heterocycloalkyl or 3-7 membered heteroaryl; R5 and R4 independently represent hydrogen, alkyl with 1-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms or aryl; Rz is hydrogen, alkyl with 1-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, cycloalkyl with 3-10 carbon atoms, heterocycloalkyl with 3-10 members, aryl or heteroaryl, or R and R taken together form 3-7- member heterocycloalkyl; And means heteroaryl; W means O, NR or is absent; Y means - (CO) -, - (CO) - or absent; Z means alkyl with 1-4 carbon atoms, -CN, -COR, COR, -CONRR, -OCOR, -NRCOR, -OCONR, -OR, -SR, -SOR, -SOR, SRN (RR), -N ( RR) or phenyl; G is aryl or heteroaryl; X means a bond, -NH, alkyl with 1-6 carbon atoms, alkenyl with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms, thioalkyl with 1-6 carbon atoms, alkylamino with 1-6 carbon atoms or (CH) J; J means alkyl with 1-6 carbon atoms, cycloalkyl with 3-7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; that effectively treat diseases caused by herpes viruses, including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpes viruses 6 and 7, and the herpes virus Kaposi. The international application was published together with an international search report.

EA200100637A 1998-12-09 1999-12-06 INHIBITORS OF HERPES VIRUSES BASED ON THIOMOCHEVINA EA200100637A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20854098A 1998-12-09 1998-12-09
PCT/US1999/028892 WO2000034269A1 (en) 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses

Publications (1)

Publication Number Publication Date
EA200100637A1 true EA200100637A1 (en) 2001-12-24

Family

ID=22774965

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100637A EA200100637A1 (en) 1998-12-09 1999-12-06 INHIBITORS OF HERPES VIRUSES BASED ON THIOMOCHEVINA

Country Status (18)

Country Link
EP (1) EP1140913A1 (en)
JP (1) JP2002531558A (en)
KR (1) KR20010086082A (en)
CN (1) CN1335843A (en)
AU (1) AU756043B2 (en)
BG (1) BG105580A (en)
BR (1) BR9916042A (en)
CA (1) CA2351390A1 (en)
CZ (1) CZ20011958A3 (en)
EA (1) EA200100637A1 (en)
HU (1) HUP0104758A3 (en)
ID (1) ID29064A (en)
IL (1) IL143203A0 (en)
NO (1) NO20012836L (en)
PL (1) PL348177A1 (en)
SK (1) SK7692001A3 (en)
TR (1) TR200101598T2 (en)
ZA (1) ZA200104373B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000055152A1 (en) * 1999-03-12 2000-09-21 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
JP3938651B2 (en) * 2000-04-13 2007-06-27 セントラル硝子株式会社 Process for producing optically active α-methyl-bis-3,5- (trifluoromethyl) benzylamine
WO2005000795A2 (en) * 2003-06-10 2005-01-06 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
EP1928847A4 (en) * 2005-08-29 2011-08-10 Gerard M Housey Theramutein modulators
CN108642926B (en) * 2018-04-26 2023-11-14 浙江汉邦新材料股份有限公司 Thiourea derivative for dyeing and cleaning terylene and preparation method thereof
WO2021100730A1 (en) * 2019-11-19 2021-05-27 武田薬品工業株式会社 Method for producing pyrrolidine compound

Also Published As

Publication number Publication date
AU756043B2 (en) 2003-01-02
ID29064A (en) 2001-07-26
CN1335843A (en) 2002-02-13
HUP0104758A2 (en) 2002-04-29
AU3112200A (en) 2000-06-26
IL143203A0 (en) 2002-04-21
BR9916042A (en) 2001-12-04
SK7692001A3 (en) 2002-09-10
PL348177A1 (en) 2002-05-06
NO20012836L (en) 2001-08-08
CA2351390A1 (en) 2000-06-15
EP1140913A1 (en) 2001-10-10
KR20010086082A (en) 2001-09-07
BG105580A (en) 2002-01-31
NO20012836D0 (en) 2001-06-08
JP2002531558A (en) 2002-09-24
HUP0104758A3 (en) 2002-05-28
CZ20011958A3 (en) 2001-10-17
TR200101598T2 (en) 2001-10-22
ZA200104373B (en) 2002-09-18

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