EA200100631A1 - INHIBITORS OF HERPES VIRUSES PRESENTING HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOMOCAWN AND HAVING A PHENYLENIA-DIAGROUTE - Google Patents

INHIBITORS OF HERPES VIRUSES PRESENTING HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOMOCAWN AND HAVING A PHENYLENIA-DIAGROUTE

Info

Publication number
EA200100631A1
EA200100631A1 EA200100631A EA200100631A EA200100631A1 EA 200100631 A1 EA200100631 A1 EA 200100631A1 EA 200100631 A EA200100631 A EA 200100631A EA 200100631 A EA200100631 A EA 200100631A EA 200100631 A1 EA200100631 A1 EA 200100631A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbon atoms
alkyl
sor
cor
heterocycloalkyl
Prior art date
Application number
EA200100631A
Other languages
Russian (ru)
Inventor
Джонатан Дэвид Блум
Кевин Джозеф Каррэн
Мартин Джозеф Дигранди
Расселл Джордж Дашин
Томас Ричард Джоунс
Стэнли Альберт Лэнг
Эдма Антониа Росс
Юджин Энтони Терефенко
Брайан Марк О'Хара
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Publication of EA200100631A1 publication Critical patent/EA200100631A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Соединения формулы (I), где R-Rнезависимо выбраны из водорода, алкила с 1-6 углеродными атомами, алкенила с 2-6 углеродными атомами, алкинила с 2-6 углеродными атомами, пергалогеналкила с 1-6 углеродными атомами, циклоалкила с 3-10 углеродными атомами, гетероциклоалкила с 3-10 углеродными членами, арила, гетероарила, галогена, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, -NRN(RR), -N(RR) или W-Y-(СН)-Z при условии, что, по крайней мере, один из радикалов R-Rне является водородом; или Rи Rили Rи R, взятые вместе, образуют 3-7-членный гетероциклоалкил или 3-7-членный гетероарил; Rи Rнезависимо представляют водород, алкил с 1-6 углеродными атомами, пергалогеналкил с 1-6 углеродными атомами или арил; Rпредставляет водород, алкил с 1-6 углеродными атомами, пергалогеналкил с 1-6 углеродными атомами, циклоалкил с 3-10 углеродными атомами, гетероциклоалкил с 3-10 членами, арил или гетероарил, или Rи R, взятые вместе, могут образовывать 3-7-членный гетероциклоалкил; W представляет О, NRили отсутствует; Y представляет -(СО)- или -(CO)- или отсутствует; Z представляет алкил с 1-4 углеродными атомами, CN, COR, COR, CONRR, OCOR, NRCOR, OCONR, OR, SR, SOR, SOR, SRN(RR), N(RR) или фенил; G представляет моноциклический гетероарил; X представляет связь, NH, алкил с 1-6 углеродными атомами, алкенил с 1-6 углеродными атомами, алкокси с 1-6 углеродными атомами, тиоалкил с 1-6 углеродными атомами, алкиламино с 1-6 углеродными атомами или (CH)J; J представляет алкил с 1-6 углеродными атомами, циклоалкил с 3-7 углеродными атомами, фенил или бензил; и n равно целому числу от 1 до 6, полезны для лечения заболеваний, вызванных вирусами герпеса, включающими цитомегаловирус человека, вирусы простого герпеса, вирус Эпстайна-Барра, вирус ветряной оспы, герпесвирусы-6 и -7 человека и герпесвирус Капоши.Отчет о международном поиске был опубликован 2001.11.29.The compounds of formula (I), where R-R is independently selected from hydrogen, alkyl with 1-6 carbon atoms, alkenyl with 2-6 carbon atoms, alkynyl with 2-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, cycloalkyl with 3- 10 carbon atoms, heterocycloalkyl with 3-10 carbon members, aryl, heteroaryl, halogen, -CN, -NO, -COR, -COR, -OR, -SR, -SOR, -SOR, -CONRR, -NRN (RR) , -N (RR) or WY- (CH) -Z with the proviso that at least one of the radicals R — R is not hydrogen; or R1 and R3 or R1 and R7, taken together, form a 3-7 membered heterocycloalkyl or 3-7 membered heteroaryl; R1 and R4 independently represent hydrogen, alkyl with 1-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, or aryl; R 1 is hydrogen, alkyl with 1-6 carbon atoms, perhaloalkyl with 1-6 carbon atoms, cycloalkyl with 3-10 carbon atoms, heterocycloalkyl with 3-10 members, aryl or heteroaryl, or R1 and R5, taken together, can form 3-7 - member heterocycloalkyl; W is O, NR or is absent; Y is - (CO) - or - (CO) - or absent; Z is alkyl with 1-4 carbon atoms, CN, COR, COR, CONRR, OCOR, NRCOR, OCONR, OR, SR, SOR, SOR, SRN (RR), N (RR) or phenyl; G represents monocyclic heteroaryl; X represents a bond, NH, alkyl with 1-6 carbon atoms, alkenyl with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms, thioalkyl with 1-6 carbon atoms, alkylamino with 1-6 carbon atoms or (CH) J ; J represents alkyl with 1-6 carbon atoms, cycloalkyl with 3-7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6, useful for treating diseases caused by herpes viruses, including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, herpes viruses-6 and -7 people, and the Kaposi herpes virus. The search was published 2001.11.29.

EA200100631A 1998-12-09 1999-12-06 INHIBITORS OF HERPES VIRUSES PRESENTING HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOMOCAWN AND HAVING A PHENYLENIA-DIAGROUTE EA200100631A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20855998A 1998-12-09 1998-12-09
PCT/US1999/028842 WO2000034258A2 (en) 1998-12-09 1999-12-06 Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group

Publications (1)

Publication Number Publication Date
EA200100631A1 true EA200100631A1 (en) 2002-02-28

Family

ID=22775044

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100631A EA200100631A1 (en) 1998-12-09 1999-12-06 INHIBITORS OF HERPES VIRUSES PRESENTING HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOMOCAWN AND HAVING A PHENYLENIA-DIAGROUTE

Country Status (18)

Country Link
EP (1) EP1144397A3 (en)
JP (1) JP2002531554A (en)
CN (1) CN1348446A (en)
AU (1) AU1934700A (en)
BG (1) BG105581A (en)
BR (1) BR9916046A (en)
CA (1) CA2350767A1 (en)
CZ (1) CZ20011956A3 (en)
EA (1) EA200100631A1 (en)
HU (1) HUP0200232A2 (en)
ID (1) ID30158A (en)
IL (1) IL143182A0 (en)
NO (1) NO20012832L (en)
PL (1) PL349217A1 (en)
SK (1) SK7682001A3 (en)
TR (1) TR200101664T2 (en)
WO (1) WO2000034258A2 (en)
ZA (1) ZA200104377B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166028A (en) * 1998-12-09 2000-12-26 American Home Products Corporation Diaminopuridine-containing thiourea inhibitors of herpes viruses
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
DK1259485T3 (en) 2000-02-29 2006-04-10 Millennium Pharm Inc Benzamides and related inhibitors of factor Xa
US7220768B2 (en) * 2003-02-11 2007-05-22 Wyeth Holdings Corp. Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
WO2008057972A1 (en) 2006-11-02 2008-05-15 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
EP2914592B1 (en) 2012-11-03 2017-10-11 Boehringer Ingelheim International GmbH Inhibitors of cytomegalovirus
US9284310B2 (en) 2012-11-03 2016-03-15 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN110565100B (en) * 2019-07-12 2021-05-07 西北工业大学 Cobaltocene cation-based corrosion inhibitor and preparation method and use method thereof
CN117769548A (en) 2021-08-05 2024-03-26 浙江海正药业股份有限公司 Aromatic acetylene derivative and preparation method and application thereof
WO2023088718A1 (en) 2021-11-19 2023-05-25 Basf Se Bicyclic compounds for the control of invertebrate pests
CN115433093A (en) * 2022-09-26 2022-12-06 无锡双启科技有限公司 Preparation method of 3-chloro-4-trifluoromethylaniline
CN115710190A (en) * 2022-11-16 2023-02-24 常州佳德医药科技有限公司 4-methoxy-2-amino-N, N-dimethylaniline, preparation method and application

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519808A (en) * 1997-04-10 2001-10-23 ファルマシア・アンド・アップジョン・カンパニー Polyaromatic antibacterial composition

Also Published As

Publication number Publication date
TR200101664T2 (en) 2002-03-21
BG105581A (en) 2001-12-31
WO2000034258A2 (en) 2000-06-15
CA2350767A1 (en) 2000-06-15
EP1144397A3 (en) 2002-09-11
JP2002531554A (en) 2002-09-24
ID30158A (en) 2001-11-08
CN1348446A (en) 2002-05-08
HUP0200232A2 (en) 2002-05-29
BR9916046A (en) 2001-10-02
PL349217A1 (en) 2002-07-01
EP1144397A2 (en) 2001-10-17
CZ20011956A3 (en) 2001-10-17
AU1934700A (en) 2000-06-26
ZA200104377B (en) 2002-12-20
NO20012832D0 (en) 2001-06-08
WO2000034258A3 (en) 2001-11-29
IL143182A0 (en) 2002-04-21
NO20012832L (en) 2001-08-07
SK7682001A3 (en) 2002-07-02

Similar Documents

Publication Publication Date Title
EA200100631A1 (en) INHIBITORS OF HERPES VIRUSES PRESENTING HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOMOCAWN AND HAVING A PHENYLENIA-DIAGROUTE
EA200000188A1 (en) DERIVATIVES 2,3-DIARYL-PYRAZOLO [1,5-B] -PYRIDAZINES, THEIR RECEIVING AND THEIR APPLICATION AS CYCLOXYGENASE-2 INHIBITORS (COX-2)
EA200100640A1 (en) HERPES VIRUS INHIBITORS, PRESENTING ACETAMIDE AND SUBSTITUTED ACETAMIDE-CONTAINING THIOMOVA
DE69500542T2 (en) 11,21-bisphenyl-19-nor-pregnane derivatives
DK0918776T3 (en) Total synthesis of antitumor acylfulvenes
ES2063300T3 (en) DERIVATIVE OF AMINOBENCENSULFONICO ACID.
EA200100634A1 (en) THIOMUTHEVIN INHIBITORS OF HERPES VIRUSES
YU47219B (en) ANTI-VIRUS TETRAHYDROIMIDASO (1,4) BENZODIAZEPINE-2-TION COMPOUNDS AND PROCEDURE FOR OBTAINING THEM
EA200100059A3 (en) New benzenesulphonamide compounds, a process for their preparation and pharmaceutical compositions containing them
EA200100638A1 (en) HERPESVIRUS INHIBITORS ON THE BASIS OF ALPHA-METHYLBENZYL-CONTAINING THIOMOVA, INCLUDING PHYLENEDIAMINO GROUP
EA200100639A1 (en) TIOMOCHEVIN DERIVATIVES CONTAINING HETEROCYCLIC CARBOXAMIDE AND PROTECTIVE PHENYLETHYLENAMINE GROUP, AS HERPES VIRUS INHIBITORS
EA200100637A1 (en) INHIBITORS OF HERPES VIRUSES BASED ON THIOMOCHEVINA
EA200501136A1 (en) TRIAZOLE COMPOUNDS USEFUL IN THERAPY
EA200500718A1 (en) SUBSTITUTED 6- (2-HALOGENFENIL) TRIAZOLOPYRIMIDINES
EA200100635A1 (en) DERIVATIVES OF THIOMOCHEVIA AS HERPES VIRUS INHIBITORS
AU3872685A (en) 3-phenyl-2-propeneamine derivatives
EA200400112A1 (en) SUBSTITUTED 6- (2-TOLYL) TRIAZOLOPYRIMIDINES
EA199800897A1 (en) FUNGICIDE MIXTURES
EA200101109A1 (en) DERIVATIVES 1-TRIFTOROMETHYL-4-HYDROXY-7-PIPERIDINYL-AMINOMETHILKHROMAN
PT1021405E (en) AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS
EA200200352A1 (en) PHENYL-AND PYRIDYL-TETRAHYDROPYRIDINES, possessing inhibitory activity in relation to tumor necrosis factor (TNF)
CA2330607A1 (en) Fungicidal mixtures
EA199901023A1 (en) FUNGICIDE MIXTURE
EA200200462A1 (en) DERIVATIVES 2-ARILKHINOLINA, THEIR RECEIVING AND THERAPEUTIC APPLICATION
EA200100806A1 (en) DERIVATIVES ALKINYL-CONTAINING HYDROXAMIC ACIDS, METHODS FOR THEIR RECOVERY AND APPLICATION OF SPECIFIED SUBSTANCES AS MATRIX METAL PROTEINASE INHIBITORS (MMP) AND FNO-ALPHA, the CFO-FRSHFREPTROF-FRTHTTLE;