FI906268A - 2-FORMYLBENZYLFOSFONSYRADERIVAT, DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING VID VAORD AV SJUKDOMAR FOERORSAKADE AV VIRUS. - Google Patents

2-FORMYLBENZYLFOSFONSYRADERIVAT, DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING VID VAORD AV SJUKDOMAR FOERORSAKADE AV VIRUS. Download PDF

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Publication number
FI906268A
FI906268A FI906268A FI906268A FI906268A FI 906268 A FI906268 A FI 906268A FI 906268 A FI906268 A FI 906268A FI 906268 A FI906268 A FI 906268A FI 906268 A FI906268 A FI 906268A
Authority
FI
Finland
Prior art keywords
deras
vaord
formylbenzylfosfonsyraderivat
foerorsakade
sjukdomar
Prior art date
Application number
FI906268A
Other languages
Finnish (fi)
Other versions
FI102280B (en
FI102280B1 (en
FI906268A0 (en
Inventor
Anuschirwan Peyman
Eugen Uhlmann
Irvin Winkler
Matthias Helsberg
Christoph Meichsner
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI906268A0 publication Critical patent/FI906268A0/en
Publication of FI906268A publication Critical patent/FI906268A/en
Application granted granted Critical
Publication of FI102280B publication Critical patent/FI102280B/en
Publication of FI102280B1 publication Critical patent/FI102280B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The compound of the formula I <IMAGE> in which R represents an aldehyde group or a group which can be converted into an aldehyde, R<1> and R<2> represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminium, lithium, ammonium or triethylammonium or R<1> and R<2> together form a cyclic diester, R<3> and R<4> represent alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R<5> and R<8> represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, X, Y or Z represent oxygen or sulphur, or prodrug forms of the compound of the formula I can be used for treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations which contain them and also their use are described.
FI906268A 1989-12-21 1990-12-19 Process for the preparation of therapeutically useful 2-formylbenzylphosphonic acid derivatives FI102280B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3942318A DE3942318A1 (en) 1989-12-21 1989-12-21 2-FORMYLBENZYLPHOSPHONIC ACID DERIVATIVES, THEIR PRODUCTION AND THE USE THEREOF FOR THE TREATMENT OF DISEASES CAUSED BY VIRUSES
DE3942318 1989-12-21

Publications (4)

Publication Number Publication Date
FI906268A0 FI906268A0 (en) 1990-12-19
FI906268A true FI906268A (en) 1991-06-22
FI102280B FI102280B (en) 1998-11-13
FI102280B1 FI102280B1 (en) 1998-11-13

Family

ID=6396038

Family Applications (1)

Application Number Title Priority Date Filing Date
FI906268A FI102280B1 (en) 1989-12-21 1990-12-19 Process for the preparation of therapeutically useful 2-formylbenzylphosphonic acid derivatives

Country Status (17)

Country Link
EP (1) EP0433928B1 (en)
JP (1) JP2997552B2 (en)
KR (1) KR100191087B1 (en)
AT (1) ATE119908T1 (en)
AU (1) AU640723B2 (en)
CA (1) CA2032772C (en)
DE (2) DE3942318A1 (en)
FI (1) FI102280B1 (en)
HU (1) HU208144B (en)
IE (1) IE67439B1 (en)
IL (1) IL96730A (en)
NO (1) NO179614C (en)
NZ (1) NZ236554A (en)
PL (1) PL288361A1 (en)
PT (1) PT96287B (en)
RU (1) RU2039063C1 (en)
ZA (1) ZA9010269B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006335737A (en) * 2005-06-03 2006-12-14 Ihara Nikkei Kagaku Kogyo Kk METHOD FOR PRODUCING BENZO[c]HETEROCYCLIC 5-MEMBERED RING COMPOUND
EP1906971A2 (en) * 2005-07-27 2008-04-09 Gilead Sciences, Inc. Antiviral compounds
JP5789430B2 (en) 2011-06-27 2015-10-07 イハラニッケイ化学工業株式会社 Method for producing 2-chloromethylbenzaldehyde, 2-chloromethylbenzaldehyde-containing composition and storage method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918064A (en) * 1987-10-21 1990-04-17 G. D. Searle & Co. Phenyl glycines for use in reducing neurotoxic injury

Also Published As

Publication number Publication date
HU208144B (en) 1993-08-30
CA2032772A1 (en) 1991-06-22
NO179614C (en) 1996-11-13
NO179614B (en) 1996-08-05
IL96730A0 (en) 1991-09-16
PL288361A1 (en) 1992-07-13
CA2032772C (en) 2001-10-23
HUT56111A (en) 1991-07-29
JP2997552B2 (en) 2000-01-11
EP0433928B1 (en) 1995-03-15
AU6830490A (en) 1991-06-27
NZ236554A (en) 1992-12-23
KR910011874A (en) 1991-08-07
FI102280B (en) 1998-11-13
EP0433928A1 (en) 1991-06-26
FI102280B1 (en) 1998-11-13
DE3942318A1 (en) 1991-06-27
IE67439B1 (en) 1996-04-03
IL96730A (en) 1996-10-31
KR100191087B1 (en) 1999-06-15
IE904625A1 (en) 1991-07-17
ATE119908T1 (en) 1995-04-15
RU2039063C1 (en) 1995-07-09
NO905521L (en) 1991-06-24
FI906268A0 (en) 1990-12-19
DE59008715D1 (en) 1995-04-20
AU640723B2 (en) 1993-09-02
ZA9010269B (en) 1991-09-25
PT96287B (en) 1998-06-30
PT96287A (en) 1991-09-30
NO905521D0 (en) 1990-12-20
JPH0616685A (en) 1994-01-25

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