NO179614C - Analogous Process for Preparing Therapeutically Active 2-Formylbenzylphosphonic Acid Derivatives - Google Patents

Analogous Process for Preparing Therapeutically Active 2-Formylbenzylphosphonic Acid Derivatives

Info

Publication number
NO179614C
NO179614C NO905521A NO905521A NO179614C NO 179614 C NO179614 C NO 179614C NO 905521 A NO905521 A NO 905521A NO 905521 A NO905521 A NO 905521A NO 179614 C NO179614 C NO 179614C
Authority
NO
Norway
Prior art keywords
alkynyl
cycloalkyl
alkenyl
hydrogen
acid derivatives
Prior art date
Application number
NO905521A
Other languages
Norwegian (no)
Other versions
NO905521D0 (en
NO905521L (en
NO179614B (en
Inventor
Anuschirwan Peyman
Eugen Uhlmann
Irvin Winkler
Matthias Helsberg
Christoph Meichsner
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO905521D0 publication Critical patent/NO905521D0/en
Publication of NO905521L publication Critical patent/NO905521L/en
Publication of NO179614B publication Critical patent/NO179614B/en
Publication of NO179614C publication Critical patent/NO179614C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The compound of the formula I <IMAGE> in which R represents an aldehyde group or a group which can be converted into an aldehyde, R<1> and R<2> represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminium, lithium, ammonium or triethylammonium or R<1> and R<2> together form a cyclic diester, R<3> and R<4> represent alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R<5> and R<8> represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, X, Y or Z represent oxygen or sulphur, or prodrug forms of the compound of the formula I can be used for treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations which contain them and also their use are described.
NO905521A 1989-12-21 1990-12-20 Analogous Process for Preparing Therapeutically Active 2-Formylbenzylphosphonic Acid Derivatives NO179614C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3942318A DE3942318A1 (en) 1989-12-21 1989-12-21 2-FORMYLBENZYLPHOSPHONIC ACID DERIVATIVES, THEIR PRODUCTION AND THE USE THEREOF FOR THE TREATMENT OF DISEASES CAUSED BY VIRUSES

Publications (4)

Publication Number Publication Date
NO905521D0 NO905521D0 (en) 1990-12-20
NO905521L NO905521L (en) 1991-06-24
NO179614B NO179614B (en) 1996-08-05
NO179614C true NO179614C (en) 1996-11-13

Family

ID=6396038

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905521A NO179614C (en) 1989-12-21 1990-12-20 Analogous Process for Preparing Therapeutically Active 2-Formylbenzylphosphonic Acid Derivatives

Country Status (17)

Country Link
EP (1) EP0433928B1 (en)
JP (1) JP2997552B2 (en)
KR (1) KR100191087B1 (en)
AT (1) ATE119908T1 (en)
AU (1) AU640723B2 (en)
CA (1) CA2032772C (en)
DE (2) DE3942318A1 (en)
FI (1) FI102280B (en)
HU (1) HU208144B (en)
IE (1) IE67439B1 (en)
IL (1) IL96730A (en)
NO (1) NO179614C (en)
NZ (1) NZ236554A (en)
PL (1) PL288361A1 (en)
PT (1) PT96287B (en)
RU (1) RU2039063C1 (en)
ZA (1) ZA9010269B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006335737A (en) * 2005-06-03 2006-12-14 Ihara Nikkei Kagaku Kogyo Kk METHOD FOR PRODUCING BENZO[c]HETEROCYCLIC 5-MEMBERED RING COMPOUND
EP1906971A2 (en) * 2005-07-27 2008-04-09 Gilead Sciences, Inc. Antiviral compounds
JP5789430B2 (en) * 2011-06-27 2015-10-07 イハラニッケイ化学工業株式会社 Method for producing 2-chloromethylbenzaldehyde, 2-chloromethylbenzaldehyde-containing composition and storage method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918064A (en) * 1987-10-21 1990-04-17 G. D. Searle & Co. Phenyl glycines for use in reducing neurotoxic injury

Also Published As

Publication number Publication date
FI906268A0 (en) 1990-12-19
IL96730A0 (en) 1991-09-16
EP0433928A1 (en) 1991-06-26
FI102280B1 (en) 1998-11-13
FI102280B (en) 1998-11-13
RU2039063C1 (en) 1995-07-09
IL96730A (en) 1996-10-31
PT96287A (en) 1991-09-30
IE67439B1 (en) 1996-04-03
ATE119908T1 (en) 1995-04-15
CA2032772A1 (en) 1991-06-22
IE904625A1 (en) 1991-07-17
PL288361A1 (en) 1992-07-13
CA2032772C (en) 2001-10-23
AU6830490A (en) 1991-06-27
DE59008715D1 (en) 1995-04-20
FI906268A (en) 1991-06-22
AU640723B2 (en) 1993-09-02
PT96287B (en) 1998-06-30
JPH0616685A (en) 1994-01-25
JP2997552B2 (en) 2000-01-11
NO905521D0 (en) 1990-12-20
DE3942318A1 (en) 1991-06-27
NO905521L (en) 1991-06-24
NZ236554A (en) 1992-12-23
HUT56111A (en) 1991-07-29
KR910011874A (en) 1991-08-07
ZA9010269B (en) 1991-09-25
NO179614B (en) 1996-08-05
EP0433928B1 (en) 1995-03-15
KR100191087B1 (en) 1999-06-15
HU208144B (en) 1993-08-30

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