GB812366A - Improvements in and relating to derivatives of pyrimidine and the preparation thereof - Google Patents
Improvements in and relating to derivatives of pyrimidine and the preparation thereofInfo
- Publication number
- GB812366A GB812366A GB2382355A GB2382355A GB812366A GB 812366 A GB812366 A GB 812366A GB 2382355 A GB2382355 A GB 2382355A GB 2382355 A GB2382355 A GB 2382355A GB 812366 A GB812366 A GB 812366A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- pyrimidine
- amino
- mercapto
- diethoxyethylpyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N Thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 3
- XHXFXVLFKHQFAL-UHFFFAOYSA-N Phosphoryl chloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 150000001241 acetals Chemical class 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 230000000875 corresponding Effects 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- -1 hydroxy, amino Chemical group 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- FBMZEITWVNHWJW-UHFFFAOYSA-N 1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one Chemical compound OC1=NC=NC2=C1C=CN2 FBMZEITWVNHWJW-UHFFFAOYSA-N 0.000 abstract 1
- HTDPDLVWFWOIBZ-UHFFFAOYSA-N 1,7-dihydropyrrolo[2,3-d]pyrimidine-4-thione Chemical compound SC1=NC=NC2=C1C=CN2 HTDPDLVWFWOIBZ-UHFFFAOYSA-N 0.000 abstract 1
- ZXIXLDUPAYIQIL-UHFFFAOYSA-N 2,6-diamino-5-(2,2-diethoxyethyl)-1H-pyrimidin-4-one Chemical compound CCOC(OCC)CC1=C(N)N=C(N)NC1=O ZXIXLDUPAYIQIL-UHFFFAOYSA-N 0.000 abstract 1
- LILXDMFJXYAKMK-UHFFFAOYSA-N 2-bromo-1,1-diethoxyethane Chemical compound CCOC(CBr)OCC LILXDMFJXYAKMK-UHFFFAOYSA-N 0.000 abstract 1
- QSKPIOLLBIHNAC-UHFFFAOYSA-N 2-chloro-acetaldehyde Chemical compound ClCC=O QSKPIOLLBIHNAC-UHFFFAOYSA-N 0.000 abstract 1
- XNINAOUGJUYOQX-UHFFFAOYSA-M 2-cyanobutanoate Chemical compound CCC(C#N)C([O-])=O XNINAOUGJUYOQX-UHFFFAOYSA-M 0.000 abstract 1
- QCZHCRBHXAFBDJ-UHFFFAOYSA-N 2-sulfanylidene-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one Chemical compound O=C1NC(=S)NC2=C1C=CN2 QCZHCRBHXAFBDJ-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N 289-95-2 Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- KNKFTJXCJWXIPP-UHFFFAOYSA-N 4,6-diamino-5-(2,2-diethoxyethyl)-1H-pyrimidine-2-thione Chemical compound CCOC(OCC)CC=1C(N)=NC(=S)NC=1N KNKFTJXCJWXIPP-UHFFFAOYSA-N 0.000 abstract 1
- IJOIJRLXVJYPIF-UHFFFAOYSA-N 4-amino-1,3-dihydropyrrolo[2,3-d]pyrimidin-2-one Chemical compound N1C(=O)NC2=NC=CC2=C1N IJOIJRLXVJYPIF-UHFFFAOYSA-N 0.000 abstract 1
- BPTCCCTWWAUJRK-UHFFFAOYSA-N 4-chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical compound ClC1=NC=NC2=C1C=CN2 BPTCCCTWWAUJRK-UHFFFAOYSA-N 0.000 abstract 1
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical group OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 abstract 1
- LNDZXOWGUAIUBG-UHFFFAOYSA-N 6-amino-1H-pyrimidine-2,4-dione Chemical compound NC1=CC(=O)NC(=O)N1 LNDZXOWGUAIUBG-UHFFFAOYSA-N 0.000 abstract 1
- YRCQGZFVHRTXOH-UHFFFAOYSA-N 6-amino-5-(2,2-diethoxyethyl)-1H-pyrimidine-2,4-dione Chemical compound CCOC(OCC)CC1=C(N)N=C(O)N=C1O YRCQGZFVHRTXOH-UHFFFAOYSA-N 0.000 abstract 1
- GKSGXTLNGDMLRR-UHFFFAOYSA-N 6-amino-5-(2,2-diethoxyethyl)-2-sulfanylidene-1H-pyrimidin-4-one Chemical compound CCOC(OCC)CC1=C(N)NC(=S)NC1=O GKSGXTLNGDMLRR-UHFFFAOYSA-N 0.000 abstract 1
- PEHVGBZKEYRQSX-UHFFFAOYSA-N 7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound NC1=NC=NC2=C1C=CN2 PEHVGBZKEYRQSX-UHFFFAOYSA-N 0.000 abstract 1
- JJTNLWSCFYERCK-UHFFFAOYSA-N 7H-pyrrolo[2,3-d]pyrimidine Chemical compound N1=CN=C2NC=CC2=C1 JJTNLWSCFYERCK-UHFFFAOYSA-N 0.000 abstract 1
- SSWARENILFGCMY-UHFFFAOYSA-N NC1=NC(=C(C(=N1)N)CC(OCC)OCC)N Chemical compound NC1=NC(=C(C(=N1)N)CC(OCC)OCC)N SSWARENILFGCMY-UHFFFAOYSA-N 0.000 abstract 1
- FELQTUFILJABMU-UHFFFAOYSA-N OC1=NC(=C(C(=N1)N)CC(OCC)OCC)N Chemical compound OC1=NC(=C(C(=N1)N)CC(OCC)OCC)N FELQTUFILJABMU-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005576 amination reaction Methods 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- 238000005660 chlorination reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises pyrrolo (2,3-d) pyrimidines of the general formula (I) (wherein X is a hydrogen atom or a hydroxy, amino or mercapto group and Y is a hydrogen or chlorine atom or a hydroxy, amino or mercapto group). These are prepared by cyclising acetals of the general formula (II) by the action of a strong acid, such as sulphuric acid, in a solvent such as 95 peer cent ethanol, followed if desired by interconversion of X and Y by processes of chlorination, amination, thiation or dethiation. <FORM:0812366/IV (b)/1> <FORM:0812366/IV (b)/2> In examples, 2,4-dihydroxy-, 2-mercapto-4-hydroxy -, 2 - mercapto - 4 - amino -, 2 - amino-4 - hydroxy -, 2,4 - diamino -, 4 - hydroxy - and 2 - hydroxy - 4 - amino - pyrrolo (2,3 - d)-pyrimidine are prepared from the corresponding acetals; pyrrolo (2,3-d) pyrimidine and 4-hydroxypyrrolo (2,3-d) pyrimidine are prepared by dethiating 4 - mercapto - and 2 - mercapto - 4-hydroxy-pyrrolo (2,3-d) pyrimidine respectively; 4 - chloropyrrolo (2,3-d) pyrimidine is prepared by the action of phosphorus oxychloride on the corresponding hydroxy compound, and converted to 4-mercaptopyrrolo (2,3-d)-pyrimidine by the action of thiourea, and to 4-aminopyrrolo (2,3-d) pyrimidine by the action of ammonia. Also described is an alternative preparation of 2,4-dihydroxypyrrolo (2,3-3) pyrimidine by heating together 6-amino-2,4-dihydroxypyrimidine and chloroacetaldehyde in aqueous sodium acetate. 2,4 - Dihydroxy - 6 - amino - 5 - diethoxyethylpyrimidine is prepared from urea and ethylacetalcyanoacetate (itself prepared from ethyl cyanoacetate and bromoacetal), 2-mercapto-4-hydroxy - 6 - amino - 5 - diethoxyethylpyrimidine from thiourea and ethylacetalcyanoacetate, 2-mercapto - 4,6 - diamino - 5 - diethoxyethylpyrimidine from thiourea and acetalmalononitrile, 2,6 - diamino - 4 - hydroxy - 5 - diethoxyethylpyrimidine from guanidine and ethylacetalcyanoacetate, 2,4,6 - triamino - 5 - diethoxyethylpyrimidine from guanidine and acetalmalonitrile and 2 - hydroxy - 4,6 - diamino - 5 - diethoxyethylpyrimidine from urea and acetalmalonitrile.
Publications (1)
Publication Number | Publication Date |
---|---|
GB812366A true GB812366A (en) | 1959-04-22 |
Family
ID=1737967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2382355A Expired GB812366A (en) | 1955-08-18 | Improvements in and relating to derivatives of pyrimidine and the preparation thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB812366A (en) |
Cited By (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3225047A (en) * | 1964-02-24 | 1965-12-21 | Bristol Myers Co | N,n'-bis(pyrimidine-5-acetyl)ethylene diamines |
US3296261A (en) * | 1965-03-09 | 1967-01-03 | Bristol Myers Co | 6-hydroxy-pyrimidine-5-acetamides |
US4571423A (en) * | 1982-03-16 | 1986-02-18 | Takeda Chemical Industries Ltd. | Substituted 5-aminomethyl-2-acylaminopyrrolo[2,3-d]pyrimidin-4-ones |
US4595530A (en) * | 1983-03-17 | 1986-06-17 | Takeda Chemical Industries, Ltd. | Thiodeazapurine derivatives |
US5349064A (en) * | 1989-06-14 | 1994-09-20 | Takeda Chemical Industries, Ltd. | Production of pyrrolopyrimidines |
US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
US7585868B2 (en) | 2006-04-04 | 2009-09-08 | The Regents Of The University Of California | Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists |
US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
US8569323B2 (en) | 2009-07-15 | 2013-10-29 | Intellikine, Llc | Substituted isoquinolin-1(2H)-one compounds, compositions, and methods thereof |
US8604032B2 (en) | 2010-05-21 | 2013-12-10 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
US8703778B2 (en) | 2008-09-26 | 2014-04-22 | Intellikine Llc | Heterocyclic kinase inhibitors |
US8703777B2 (en) | 2008-01-04 | 2014-04-22 | Intellikine Llc | Certain chemical entities, compositions and methods |
US8785454B2 (en) | 2009-05-07 | 2014-07-22 | Intellikine Llc | Heterocyclic compounds and uses thereof |
US8785470B2 (en) | 2011-08-29 | 2014-07-22 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8809349B2 (en) | 2011-01-10 | 2014-08-19 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
US8901133B2 (en) | 2010-11-10 | 2014-12-02 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9096611B2 (en) | 2008-07-08 | 2015-08-04 | Intellikine Llc | Kinase inhibitors and methods of use |
US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
US9321772B2 (en) | 2011-09-02 | 2016-04-26 | The Regents Of The University Of California | Substituted pyrazolo[3,4-D]pyrimidines and uses thereof |
US9359365B2 (en) | 2013-10-04 | 2016-06-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9359349B2 (en) | 2007-10-04 | 2016-06-07 | Intellikine Llc | Substituted quinazolines as kinase inhibitors |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
JP2017008027A (en) * | 2007-06-08 | 2017-01-12 | セノミックス インコーポレイテッド | Modulation of chemosensory receptors and ligands associated therewith |
US9629843B2 (en) | 2008-07-08 | 2017-04-25 | The Regents Of The University Of California | MTOR modulators and uses thereof |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9775844B2 (en) | 2014-03-19 | 2017-10-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US10087154B2 (en) | 2008-07-31 | 2018-10-02 | Senomyx, Inc. | Processes and intermediates for making sweet taste enhancers |
US10131668B2 (en) | 2012-09-26 | 2018-11-20 | The Regents Of The University Of California | Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1 |
US10160761B2 (en) | 2015-09-14 | 2018-12-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US11110096B2 (en) | 2014-04-16 | 2021-09-07 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US11147818B2 (en) | 2016-06-24 | 2021-10-19 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US11897889B2 (en) | 2020-08-18 | 2024-02-13 | Incyte Corporation | Process and intermediates for preparing a JAK1 inhibitor |
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US11945813B2 (en) | 2018-08-07 | 2024-04-02 | Firmenich Incorporated | 5-substituted 4-amino-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof |
-
1955
- 1955-08-18 GB GB2382355A patent/GB812366A/en not_active Expired
Cited By (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3225047A (en) * | 1964-02-24 | 1965-12-21 | Bristol Myers Co | N,n'-bis(pyrimidine-5-acetyl)ethylene diamines |
US3296261A (en) * | 1965-03-09 | 1967-01-03 | Bristol Myers Co | 6-hydroxy-pyrimidine-5-acetamides |
US4571423A (en) * | 1982-03-16 | 1986-02-18 | Takeda Chemical Industries Ltd. | Substituted 5-aminomethyl-2-acylaminopyrrolo[2,3-d]pyrimidin-4-ones |
US4595530A (en) * | 1983-03-17 | 1986-06-17 | Takeda Chemical Industries, Ltd. | Thiodeazapurine derivatives |
US5349064A (en) * | 1989-06-14 | 1994-09-20 | Takeda Chemical Industries, Ltd. | Production of pyrrolopyrimidines |
US5496946A (en) * | 1989-06-14 | 1996-03-05 | Takeda Chemical Industries, Ltd. | Production of pyrrolopyrimidines and intermediates therefor |
US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
US7585868B2 (en) | 2006-04-04 | 2009-09-08 | The Regents Of The University Of California | Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists |
US8642604B2 (en) | 2006-04-04 | 2014-02-04 | The Regents Of The University Of California | Substituted pyrazolo[3,2-d]pyrimidines as anti-cancer agents |
US9493467B2 (en) | 2006-04-04 | 2016-11-15 | The Regents Of The University Of California | PI3 kinase antagonists |
JP2017008027A (en) * | 2007-06-08 | 2017-01-12 | セノミックス インコーポレイテッド | Modulation of chemosensory receptors and ligands associated therewith |
US9359349B2 (en) | 2007-10-04 | 2016-06-07 | Intellikine Llc | Substituted quinazolines as kinase inhibitors |
US11433065B2 (en) | 2008-01-04 | 2022-09-06 | Intellikine Llc | Certain chemical entities, compositions and methods |
US9822131B2 (en) | 2008-01-04 | 2017-11-21 | Intellikine Llc | Certain chemical entities, compositions and methods |
US9216982B2 (en) | 2008-01-04 | 2015-12-22 | Intellikine Llc | Certain chemical entities, compositions and methods |
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