GB1134852A - Biologically active pyrazolopyrimidines - Google Patents

Biologically active pyrazolopyrimidines

Info

Publication number
GB1134852A
GB1134852A GB2139665A GB2139665A GB1134852A GB 1134852 A GB1134852 A GB 1134852A GB 2139665 A GB2139665 A GB 2139665A GB 2139665 A GB2139665 A GB 2139665A GB 1134852 A GB1134852 A GB 1134852A
Authority
GB
United Kingdom
Prior art keywords
amino
reacting
formula
alkyl group
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2139665A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB2139665A priority Critical patent/GB1134852A/en
Priority to CH728666A priority patent/CH484929A/en
Priority to ES0326892A priority patent/ES326892A1/en
Priority to BE681349D priority patent/BE681349A/xx
Priority to FR62302A priority patent/FR1480652A/en
Priority to FR73604A priority patent/FR5679M/fr
Publication of GB1134852A publication Critical patent/GB1134852A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,134,852. Substituted pyrazolo-pyrimidines. WELLCOME FOUNDATION Ltd. (Burroughs Wellcome & Co. (U.S.A.)). 19 May, 1966 [20 May, 1965], No. 21396/65. Heading C2C. Novel compounds of the Formula (I) or tautomers thereof, in which X is a hydrogen atom or a hydroxy group. R<SP>1</SP> is an alkyl group of 1 to 3 carbon atoms when X is hydrogen, and an alkyl group of 2 or 3 carbon atoms when X is hydroxy are prepared by: (a) reacting a 3-amino-4- alkylcarboxamidopyrazole with a compound H.CO.Z where the alkyl group is R<SP>1</SP> and Z is a substituted or unsubstituted amino, alkoxy or hydroxy group, and cyclizing, if necessary, with heat; or (b) reacting the same 3-amino-4- alkylcarboxamidopyrazole with a compound A.CO.B wherein A and B are the same or different and may be amino or alkoxy groups, or halogen atoms, or taken together, an imino group, and heating if necessary; or (c) reacting a 3 - amino - 4 - carbalkoxypyrazole with R<SP>1</SP>NCO and cyclizing with ethanol and HC1. Specified compounds of Formula (I) are 4- oxo - 5 - N - methyl - 4,5 - dihydropyrazolo- (3,4-d) pyrimidine, and the 5-N-ethyl and 5-N- n-propyl analogues, and 4,6-dioxo-5-N-ethyl- 4,5,6,7 - tetrahydropyrazolo - (3,4 - d) - pyrimidine and the 5-N-n-propyl analogue. 3 - Amino - 4 - N - methylcarboxamidopyrazole is prepared by treating 3-amino-4-carbethoxypyrazole with methylamine in the presence of sodium methoxide. Pharmaceutical compositions for the inhibition of xanthrine oxidase, for treatment of hyperuricemias and as potentiators for antimetabolic 6-substituted purines comprise compounds of the Formula (I) in admixture with carriers in the form of tablets, capsules, cachets, ampoules, suppositories, powders, granules, ointments and aqueous, non-aqueous or emulsified liquids.
GB2139665A 1965-05-20 1965-05-20 Biologically active pyrazolopyrimidines Expired GB1134852A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB2139665A GB1134852A (en) 1965-05-20 1965-05-20 Biologically active pyrazolopyrimidines
CH728666A CH484929A (en) 1965-05-20 1966-05-18 Process for the preparation of pyrazolo (3,4-d) pyrimidines
ES0326892A ES326892A1 (en) 1965-05-20 1966-05-18 A method for the production of a xantin oxidase inhibitor. (Machine-translation by Google Translate, not legally binding)
BE681349D BE681349A (en) 1965-05-20 1966-05-20
FR62302A FR1480652A (en) 1965-05-20 1966-05-20 Pyrimidine derivatives and their preparation
FR73604A FR5679M (en) 1965-05-20 1966-08-19

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2139665A GB1134852A (en) 1965-05-20 1965-05-20 Biologically active pyrazolopyrimidines

Publications (1)

Publication Number Publication Date
GB1134852A true GB1134852A (en) 1968-11-27

Family

ID=10162223

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2139665A Expired GB1134852A (en) 1965-05-20 1965-05-20 Biologically active pyrazolopyrimidines

Country Status (5)

Country Link
BE (1) BE681349A (en)
CH (1) CH484929A (en)
ES (1) ES326892A1 (en)
FR (1) FR5679M (en)
GB (1) GB1134852A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191136B1 (en) 1997-11-07 2001-02-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191136B1 (en) 1997-11-07 2001-02-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
US6569862B1 (en) 1997-11-07 2003-05-27 Johns Hopkins University Methods for treatment of disorders of cardiac contractility

Also Published As

Publication number Publication date
FR5679M (en) 1968-01-08
CH484929A (en) 1970-01-31
ES326892A1 (en) 1967-07-01
BE681349A (en) 1966-11-21

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