ES436624A1 - Pyrimidones - Google Patents

Pyrimidones

Info

Publication number
ES436624A1
ES436624A1 ES436624A ES436624A ES436624A1 ES 436624 A1 ES436624 A1 ES 436624A1 ES 436624 A ES436624 A ES 436624A ES 436624 A ES436624 A ES 436624A ES 436624 A1 ES436624 A1 ES 436624A1
Authority
ES
Spain
Prior art keywords
formula
hydrogen
carbon atoms
see formula
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436624A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES436624A1 publication Critical patent/ES436624A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A procedure to prepare new hydroxypyrimidines of the formula: ** (See formula) ** and the pharmaceutically acceptable salts thereof, wherein: R4 is hydrogen, halogen, lower alkyl of 1 to 3 carbon atoms, methoxy or carboxy and R5 is hydrogen, chlorine or methyl, characterized by reacting ethanol, thiourea and methoxide of sodium with the sodium salt of a compound of the formula: ** (See formula) ** where R4 and R5 are as defined above, and R6 is an alkyl group having up to 3 carbon atoms, the thiouracil formed is desulfurized and the pyrimidine is obtained by subsequent acidification. (Machine-translation by Google Translate, not legally binding)
ES436624A 1971-10-29 1975-04-15 Pyrimidones Expired ES436624A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19400671A 1971-10-29 1971-10-29

Publications (1)

Publication Number Publication Date
ES436624A1 true ES436624A1 (en) 1977-02-01

Family

ID=22715935

Family Applications (2)

Application Number Title Priority Date Filing Date
ES407730A Expired ES407730A1 (en) 1971-10-29 1972-10-18 Pyrimidones
ES436624A Expired ES436624A1 (en) 1971-10-29 1975-04-15 Pyrimidones

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES407730A Expired ES407730A1 (en) 1971-10-29 1972-10-18 Pyrimidones

Country Status (25)

Country Link
JP (2) JPS5337870B2 (en)
AR (2) AR198798A1 (en)
AT (2) AT321308B (en)
AU (1) AU467600B2 (en)
BE (1) BE790125A (en)
CA (1) CA980778A (en)
CH (2) CH555832A (en)
DE (3) DE2248741C3 (en)
DK (1) DK131465B (en)
EG (1) EG11013A (en)
ES (2) ES407730A1 (en)
FI (1) FI55503C (en)
FR (1) FR2157865B1 (en)
GB (2) GB1377308A (en)
IE (1) IE37043B1 (en)
IL (2) IL40458A (en)
LU (1) LU66304A1 (en)
NL (1) NL166470C (en)
NO (1) NO136574C (en)
PH (2) PH10129A (en)
PL (2) PL89852B1 (en)
SE (2) SE393376B (en)
SU (2) SU498908A3 (en)
YU (2) YU35125B (en)
ZA (1) ZA727362B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151912U (en) * 1979-04-17 1980-11-01
JPS5752409Y2 (en) * 1979-11-05 1982-11-15
DE3222914A1 (en) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg SUBSTITUTED 5-PHENYLTHIO-6-AMINO-PYRIMIDINONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE, AND PREPARATIONS CONTAINING THESE COMPOUNDS
JPH0655686B2 (en) * 1988-08-30 1994-07-27 宇部興産株式会社 Process for producing p-bromophenoxyacetaldehyde dialkyl acetals
KR101452518B1 (en) 2005-08-22 2014-10-21 멜리어 파마슈티칼스 아이, 인코포레이티드 Methods and formulations for modulating lyn kinase activity and treating related disorders
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
WO2011150300A1 (en) 2010-05-28 2011-12-01 Melior Pharmaceuticals I, Inc. Prevention of pancreatic beta cell degeneration
CN110785170B (en) 2017-04-10 2023-03-28 梅里奥尔医药I公司 Treatment of adipocytes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913462A (en) * 1959-11-17 Eahl h
GB951432A (en) * 1959-03-17 1964-03-04 Wellcome Found Pyrimidine derivatives and the manufacture thereof

Also Published As

Publication number Publication date
PL84634B1 (en) 1976-04-30
DK131465B (en) 1975-07-21
DE2264374C3 (en) 1981-07-23
IL40458A (en) 1976-05-31
FI55503B (en) 1979-04-30
DE2264374B2 (en) 1980-08-07
DE2248741B2 (en) 1974-11-14
NL166470C (en) 1981-08-17
ZA727362B (en) 1973-11-28
SE7505279L (en) 1975-05-06
NO136574C (en) 1977-09-28
DE2248741C3 (en) 1975-06-26
CH555832A (en) 1974-11-15
JPS5422995B2 (en) 1979-08-10
FI55503C (en) 1979-08-10
LU66304A1 (en) 1973-05-03
IL48790A (en) 1976-05-31
SE397090B (en) 1977-10-17
AU467600B2 (en) 1975-12-04
JPS5337870B2 (en) 1978-10-12
NL7213959A (en) 1973-05-02
SU498908A3 (en) 1976-01-05
DK131465C (en) 1975-12-08
PH10129A (en) 1976-09-02
SU505362A3 (en) 1976-02-28
DE2264657A1 (en) 1974-06-20
YU36295B (en) 1982-06-18
FR2157865A1 (en) 1973-06-08
DE2248741A1 (en) 1973-05-03
IE37043L (en) 1973-04-29
BE790125A (en) 1973-04-16
PH11594A (en) 1978-03-31
IE37043B1 (en) 1977-04-27
JPS53116386A (en) 1978-10-11
AT321308B (en) 1975-03-25
SE393376B (en) 1977-05-09
YU35125B (en) 1980-09-25
AR198798A1 (en) 1974-07-24
DE2264657C2 (en) 1982-09-16
AT320656B (en) 1975-02-25
IL40458A0 (en) 1972-11-28
AR196263A1 (en) 1973-12-10
CH549579A (en) 1974-05-31
NO136574B (en) 1977-06-20
YU255172A (en) 1980-03-15
DE2264374A1 (en) 1973-05-24
AU4722872A (en) 1974-04-04
PL89852B1 (en) 1976-12-31
FR2157865B1 (en) 1975-10-31
GB1377308A (en) 1974-12-11
CA980778A (en) 1975-12-30
YU99179A (en) 1981-08-31
EG11013A (en) 1976-11-30
NL166470B (en) 1981-03-16
ES407730A1 (en) 1976-01-16
IL48790A0 (en) 1976-03-31
GB1377720A (en) 1974-12-18
JPS4852780A (en) 1973-07-24

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